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Angela H. Ting, PhD
Associate Professor, Department of Molecular Medicine, School of MedicineAssistant Professor, Department of Genetics and Genome Sciences, School of MedicineMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterEmail: tinga@ccf.org
Phone: 216.444.0682
I research the mechanisms of epigenetic gene silencing and understanding the functional relevance of DNA methylation in diseases.
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Boaz Tirosh, PhD
Professor, Department of Biochemistry, School of MedicineCo-Leader, Molecular Oncology Program, Case Comprehensive Cancer CenterProfessor, Department of Pharmacology, School of MedicineEmail: boaz.tirosh@case.edu
Phone: 216.368.0905
We are using animal models to study the role of stress responses in immunity. We also utilize CRISPR/Cas9 mutagenesis to study the role of stress signaling in cancer, particularly the development of resistance to therapy.
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Gregory P. Tochtrop, PhD
Professor, Department of Chemistry, College of Arts and SciencesAssistant Professor, Department of Pharmacology, School of MedicineMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterEmail: gpt6@case.edu
Phone: 216.368.2351
I study the linkage between oxidative stress pathways and lipid peroxidation, and the role of the fatty acid binding protein family in lipid signaling.
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Bruce D. Trapp, PhD
Professor, Department of Neurosciences, School of MedicineProfessor, Department of Molecular Medicine, School of MedicineProfessor, Department of Pediatrics, School of MedicineEmail: trappb@ccf.org
Phone: 216.444.7177
My research is in cellular and molecular biology of myelination, demyelination, and remyelination with a focus on multiple Sclerosis.
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Saba Valadkhan, MD, PhD
Assistant Professor, Department of Molecular Biology and Microbiology, School of MedicineAssistant Professor, Department of Biochemistry, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: saba.valadkhan@case.edu
Phone: 216.368.1068
I study the role of long non-coding RNAs (lncRNAs) in human and mouse, including high throughput studies of cellular gene expression pattern (bulk and single-cell RNA-seq, ChIP-seq, etc).
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Anna Valujskikh, PhD
Department of Inflammation and Immunity, Lerner Research InstituteEmail: anna.valujskikh@case.edu
Phone: 216.445.5452
I research cellular and humoral alloimmune responses to solid organ transplants.
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Focco van den Akker, PhD
Associate Professor, Department of Biochemistry, School of MedicineVice-Chair of Faculty Development, Department of BiochemistryChair of Department Committee on Appointment, Promotion and Tenure, Department of BiochemistryDirector, Research Honors Track Program, Department of BiochemistryEmail: focco.vandenakker@case.edu
Phone: 216.368.8511
I focus on structural biology, infectious diseases/antibiotic resistance, cardiovascular diseases, small-molecule therapeutics design, and cell signaling.
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Johannes von Lintig, PhD
Vice Chair for Research, Department of Pharmacology, School of MedicineProfessor, Department of Pharmacology, School of MedicineSilvia Balslew Page - William J. Reinhart MD ProfessorDirector, Visual Science Training ProgramDirector, Specialized Animal Core of the Visual Science CenterEmail: jxv99@case.edu
Phone: 216.368.3528
Our laboratory studies the role of carotenoids and their retinoid metabolites in vision. Specically, we analyze how these lipids are absorbed, distributed in the body, and metabolized to biologically active metabolites, including the visual chrmophore. We use mouse modles with mutation in these genes to establish treatments of associated blining diseases.
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David Wald, MD, PhD
Professor, Department of Pathology, School of MedicineCo-Leader, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: david.wald@case.edu
Phone: 216.368.5668
My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.
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Li Lily Wang, PhD
Professor, Department of Molecular Medicine, School of MedicineMember, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: wangl9@ccf.org
Phone: 216.973.5628
The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and Case Western Reserve University. Immune-checkpoint blockade therapies have revolutionized the field of Cancer Immunotherapy. The Wang laboratory is among the first groups to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer Immunotherapy. Current projects are multi-disciplinary and involve elucidating the epigenetic and metabolic regulations by novel inhibitory receptors on tumor-associated cytotoxic T cells and tumor-associated macrophages or myeloid derived suppressor cells. We are also investigating the mechanisms of resistance following chimeric antigen receptor (CAR) T cell-based therapies in lymphoma patients.