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John Tilton, MD
Associate Professor, Department of Nutrition, School of MedicineVice Chair, Research, Department of Nutrition, School of MedicineAssistant Professor, Department of Molecular Biology and Microbiology, School of MedicineAssistant Professor, Center for Proteomics and Bioinformatics, School of MedicineEmail: john.c.tilton@case.edu
Phone: 216.368.3360
My lab repurposes viruses for in vivo delivery of protein and nucleic acid therapeutics. We understand the heterogeneity of viruses and other small particles using nanoscale flow cytometry and unravel unraveling mechanisms of extracellular vesicle-mediated fusion and intercellular signaling.
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Angela H. Ting, PhD
Associate Professor, Department of Molecular Medicine, School of MedicineAssistant Professor, Department of Genetics and Genome Sciences, School of MedicineMember, Cancer Genomics and Epigenomics Program, Case Comprehensive Cancer CenterEmail: tinga@ccf.org
Phone: 216.444.0682
I research the mechanisms of epigenetic gene silencing and understanding the functional relevance of DNA methylation in diseases.
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Boaz Tirosh, PhD
Professor, Department of Biochemistry, School of MedicineCo-Leader, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: boaz.tirosh@case.edu
Phone: 216.368.0905
We are using animal models to study the role of stress responses in immunity. We also utilize CRISPR/Cas9 mutagenesis to study the role of stress signaling in cancer, particularly the development of resistance to therapy.
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Gregory P. Tochtrop, PhD
Professor, Department of Chemistry, College of Arts and SciencesAssistant Professor, Department of Pharmacology, School of MedicineMember, Developmental Therapeutics Program, Case Comprehensive Cancer CenterEmail: gpt6@case.edu
Phone: 216.368.2351
I study the linkage between oxidative stress pathways and lipid peroxidation, and the role of the fatty acid binding protein family in lipid signaling.
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Bruce D. Trapp, PhD
Professor, Department of Neurosciences, School of MedicineProfessor, Department of Molecular Medicine, School of MedicineProfessor, Department of Pediatrics, School of MedicineEmail: trappb@ccf.org
Phone: 216.444.7177
My research is in cellular and molecular biology of myelination, demyelination, and remyelination with a focus on multiple Sclerosis.
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Saba Valadkhan, MD, PhD
Assistant Professor, Department of Molecular Biology and Microbiology, School of MedicineAssistant Professor, Department of Biochemistry, School of MedicineMember, Molecular Oncology Program, Case Comprehensive Cancer CenterEmail: saba.valadkhan@case.edu
Phone: 216.368.1068
I study the role of long non-coding RNAs (lncRNAs) in human and mouse, including high throughput studies of cellular gene expression pattern (bulk and single-cell RNA-seq, ChIP-seq, etc).
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Anna Valujskikh, PhD
Department of Inflammation and Immunity, Lerner Research InstituteEmail: anna.valujskikh@case.edu
Phone: 216.445.5452
I research cellular and humoral alloimmune responses to solid organ transplants.
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Focco van den Akker, PhD
Associate Professor, Department of Biochemistry, School of MedicineDirector, Department of Biochemistry, Research Honors Track ProgramEmail: focco.vandenakker@case.edu
Phone: 216.368.8511
I focus on structural biology, infectious diseases/antibiotic resistance, cardiovascular diseases, small-molecule therapeutics design, and cell signaling.
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Johannes von Lintig, PhD
Vice Chair for Research, Department of Pharmacology, School of MedicineProfessor, Department of Pharmacology, School of MedicineSilvia Balslew Page - William J. Reinhart MD ProfessorDirector, Visual Science Training ProgramDirector, Specialized Animal Core of the Visual Science CenterEmail: jxv99@case.edu
Phone: 216.368.3528
Our laboratory studies the role of carotenoids and their retinoid metabolites in vision. Specically, we analyze how these lipids are absorbed, distributed in the body, and metabolized to biologically active metabolites, including the visual chrmophore. We use mouse modles with mutation in these genes to establish treatments of associated blining diseases.
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David Wald, MD, PhD
Professor, Department of Pathology, School of MedicineCo-Leader, Immune Oncology Program, Case Comprehensive Cancer CenterEmail: david.wald@case.edu
Phone: 216.368.5668
My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.