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Youwei Zhang, PhD
ProfessorDepartment of PharmacologySchool of MedicineChairDepartment of PharmacologyGraduate Qualification CommitteeVice ChairmanCommittee for Biomedical ResearchSchool of MedicineDirectorSOM Graduate Program C3MB Cell Biology CourseSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: yxz169@case.edu
Phone: 216.368.7588
My research focuses on molecular mechanisms regulating genome stability and their potential application in cancer therapy.
Peng Zhang, PhD
Assistant ProfessorDepartment of NeurosciencesSchool of MedicineEmail: pxz187@case.edu
Phone: 216.368.2064
Our laboratory combines molecular, cellular, and electrophysiological approaches with state-of-art Expansion Microscopy and 3D electron microscopy in the cultured neuron and transgenic mouse models to analyze how neurons establish their communications through a specialized unit termed “synapse”. We are particularly interested in an interdisciplinary study about the role of extracellular polysaccharide in regulating the structure and function of synapses. Elucidating these mechanisms is important for understanding how synapses develop in health and how they dysfunction in neurodevelopmental and neurodegenerative disorders.
Yi Zhang, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: yi.zhang26@case.edu
Phone: 216.368.0424
Our research investigates topics at the interface of chemistry and biology, focusing on elucidating the molecular basis of cellular pathways important for human health and disease biology. We employ integrative approaches to study the structure and behavior of macromolecules, understand their functions, and then predict and validate their roles in different cellular contexts. Current research areas include selective autophagy, chromatin biology and epigenetics, and biomolecular condensates.
Chen Zhao, MD, PhD
Associate ProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: cxz545@case.edu
Phone: 216.368.4712
We are focusing on seeking in-depth understanding of the mechanisms of hematopoietic stem/progenitor cell (HSPC) self-renewal, the interactions of HSPCs and bone marrow microenvironment, and how these become dysregulated to cause leukemia/lymphoma. Specifically, we are focusing on 1) How HSF1 specifically regulates AML stem cells; and 2) how B-myeloid conversion is regulated in a pathological context.
Qing Yin Zheng, PhD
Associate ProfessorDepartment of OtolaryngologySchool of MedicineAssociate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: qing.zheng@case.edu
Phone: 216.844.3441
I research the genes and molecular pathways involved in mouse models of human deafness, including Otitis Media and Usher syndrome.
Lan Zhou, MD, PhD
MemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: lan.zhou@case.edu
Phone: 216.368.1671
My labs studies Notch signaling in stress hematopoiesis, hematopoietic stem cell niche, and leukemia microenvironment. Additional projects include pathogenesis of inflammation-associated colorectal cancer mouse models and targeting pancreatic cancer metabolic vulnerability and drug resistance.
Xiongwei Zhu, PhD
ProfessorDepartment of PathologySchool of MedicineProfessorDepartment of NeurologySchool of MedicineCo-Director, Pathology Graduate ProgramDepartment of PathologySchool of MedicineDirector, Molecular and Cellular Basis for Disease Training ProgramDepartment of PathologySchool of MedicineEmail: xiongwei.zhu@case.edu
Phone: 216.368.5903
My lab studies pathogenic mechanisms underlying neurodegeneration in age-related neurodegenerative diseases including Alzheimer's disease and Parkinson disease with a focus on mitochondrial dysfunction and oxidative stress. A variety of experimental systems are used, including primary and transformed neuronal cells and multiple mouse models representing these disorders as well as brain tissues from human patients.
Xiaofeng Zhu, PhD
ProfessorDepartment of Population and Quantitative Health SciencesSchool of MedicineFacultyCleveland Institute for Computational BiologyEmail: xxz10@case.edu
Phone: 216.368.0201
We are focused on developing statistical and deep learning methods, along with software and bioinformatic tools, for analyzing genetic and genomic data. Additionally, we aim to understand the biological mechanisms underlying various disease phenotypes, including cardiovascular disease, hypertension, obesity, sleep disorders, and Alzheimer's Disease.
Shiwei Zhu, PhD
Assistant ProfessorDepartment of Physiology and BiophysicsSchool of MedicineEmail: shiwei.zhu@case.edu
Phone: 216.368.3400
We are interested in utilizing an advancing imaging technique, cryo-electron tomography, to visualize antimicrobial protein complexes directly in their native cellular context. We also employ cryo-EM single particle analysis and other biophysical techniques to study the structure and mechanism of antimicrobial macromolecular complexes. We aim to provide essential structural information to help develop strategies to combat infectious diseases.
Richard Zigmond, PhD
ProfessorDepartment of NeurosciencesSchool of MedicineProfessorDepartment of Neurological SurgerySchool of MedicineProfessorDepartment of PathologySchool of MedicineEmail: rez@case.edu
Phone: 216.368.4614
I focus on changes in neuronal gene expression after injury and their relationship to nerve regeneration. I study the role of immune cells in nerve degeneration and regeneration, and compare nerve regeneration in different types of sensory neurons.