Open Positions

Faculty

Assistant, Associate, or Professor level

The Center for Global Health and Diseases (CGHD) and Department of Pathology is recruiting new faculty to expand its research portfolio at the Assistant, Associate, or Professor level. Applications are encouraged from candidates with basic science and clinical research programs in any area of immunity and pathogenesis of infectious disease of global health significance.   Applicants with international collaborative research programs are encouraged to apply. These positions will be supported by substantial start-up packages. The CGHD has research programs in adult and pediatric infectious disease, including malaria, schistosomiasis, filariasis and onchocerciasis, SARS-CoV2, HIV, and mosquito-borne viral diseases through international partnerships in Africa, Asia, Europe, and Latin America. The CGHD and Pathology together support research from basic immunology to international clinical trials, an Immunology Training Program, and NIH training grants in both immunology and global health/infectious diseases. Annual research funding in immunology and infectious diseases exceeds $100M across CWRU and affiliates, and the Pathology Department is ranked in the top 10 for NIH funding. Other institutional strengths include the CWRU Center for AIDS Research, the Tuberculosis Research Unit, the Division of Infectious Diseases and HIV Medicine and the Department of Molecular Biology and Microbiology. CWRU values interdisciplinary thinking, creative collaboration and entrepreneurial ideas. It also believes strongly in the vital importance of diversity within the professorial ranks, both in terms of women and underrepresented minorities.

Candidates at the Assistant Professor level should have a demonstrated record of success in multiple venues with substantial potential to obtain external funding. Candidates at the Associate or Full Professor levels should have robust and active research programs and demonstrable national or international reputations, respectively. Associate and Full Professor candidates should also have a history of mentorship and leadership.

Interested candidates should forward a cover letter, CV, statement of research interests, a diversity and equity statement (see below), and names of 3 references in a single pdf file to cghdsearch@case.edu.

Diversity and equity statement: Applicants are also asked to submit a statement (1/2 page) explaining how their research, teaching, and/or service have contributed to diversity, equity and inclusion within their scholarly field(s) and/or how their individual and/or collaborative efforts have promoted structural justice inside and outside institutions of higher learning. This statement should also reflect on the ways in which the candidate’s continued efforts will foster a culture of diversity, pluralism, and individual difference at Case Western Reserve University into the future. 

 

Staff

Research Assistant III (Job # 9238) - Burgener Lab

Job Description

POSITION OBJECTIVE

Working under limited supervision, coordinate work in systems biology, including the microbiome, proteomics, and immunology research. Our research program is interested on understanding how the microbiome contributes to human health and susceptibility to infectious disease, with a focus on women’s health.  The research team collaborates with international partners in Africa, Europe, and Canada.

ESSENTIAL FUNCTIONS

  1. Coordinate laboratory/ research activities with technicians and post-doctoral scholars. Organize experiments and the preparation of samples for mass spectrometry analysis. Maintain experimental records on all activities, protocols, data, etc. Ensure laboratory safety. (35%)
  2. Work closely with the principal investigator to optimize and troubleshoot procedures to comply with expected outcomes. (10%)  
  3. Carry out complex research assignments of a non-routine nature integrating multiple systems biology tools (proteomics, metabolomics, metagenomics, immunology) to study host-microbial interactions in human health. Operate and manage liquid chromatography systems related to proteomics experiments. Execute, analyse, and deliver on assigned research projects. (10%)  
  4. Devise new protocols and techniques for research projects involving a high degree of skill and training. This could include developing/adapting proteomic sample processing protocols for different biological samples, testing and optimizing workflows for microbiome, proteomic, metabolomic, or immunology analysis, etc. (10%)  
  5. Evaluate adequacy of techniques; study and test new procedures and analyzes data. This could include processing of samples for new experiments, handling data processing and performing data analysis in coordination with Bioinformatics lead. Perform analysis of data from proteomics experiments. (10%)
  6. Supervise students and technicians in standard laboratory policies as well as microbiome, proteomic, and immunology research techniques. (10%)
  7. Monitor the laboratory budget. Set up apparatus and perform a wide variety of equipment and standardized procedures.  Oversee/maintain inventory, equipment and facilities, and recommend purchases. Responsible for environmental safely rules and handling biohazard waste. (10%)

NONESSENTIAL FUNCTIONS  

  1. Participate in weekly research meetings and conferences to present data. May co-author research projects. (3%)
  2. Perform other duties as assigned. (2%)

CONTACTS

Department: Frequent contact with principal investigator for project and lab communication, infrequent contact with CGHD and Pathology department administration.

University: Frequent contact with other university collaborating departments including other basic science departments regarding on-going projects and lab activities.

External: Infrequent contact with vendors, IRB, other collaborating institutions.

Technical, students: Daily contact with students and technicians to explain data, techniques, etc., and to maintain workflow.

SUPERVISORY RESPONSIBILITY

Supervise students, post docs, and technicians

QUALIFICATIONS

Experience: 3 to 5 years of related experience required.

Education/Licensing: Bachelor of Science degree required.

REQUIRED SKILLS

  1. Has knowledge of commonly-used concepts, practices, and procedures within microbiology, biochemistry, genetics, immunology, chemistry or related discipline.
  2. Ability to rely on instructions and pre-established guidelines to perform the functions of the job.
  3. Ability to operate laboratory equipment including Thermo Orbitrap Mass Spectrometers for proteomics/metabolomics, Illumina sequencers for microbiome and DNA analysis, advanced liquid chromatography systems, tissue culture systems.
  4. Ability to ensure laboratory safety.
  5. Ability to perform basic laboratory assays.
  6. Must be highly motivated, responsible, dependable and a self-starter. Ability to meet consistent attendance.
  7. Good/strong organization skills; ability to multi-task, prioritize and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through.  
  8. Ability to work with sensitive information and maintain confidentiality.  
  9. Excellent customer service skills; ability to maintain effective working relationships and address the potential and current needs of customers. Ability to work effectively independently and collaboratively within a team. Ability to interact with colleagues, supervisors, and customers face to face.
  10. Effective problem-solving skills; must demonstrate sound judgment and good decision-making. 

WORKING CONDITIONS

The employee will work mostly in Biosafety Level 2 (BSL-2) facilities and will use infectious materials, and general chemicals.  This job will include handling of human biological specimens that may be infected with HIV, malaria, TB, and other pathogens. This position may provide opportunities for international travel and presentations at international conferences

 

Research Assistant IV (Job # 9239) - Burgener Lab

Job Description

POSITION OBJECTIVE

Working with a high degree of independence and under general direction, the Research Assistant 4 will coordinate work in metabolomics, chromatography, and mass spectrometry. The research assistant 4 will work with the Mass Spectrometry Scientist. This will include the daily management and operation of the latest liquid chromatography instrumentation (Agilent 1260 HPLC, Vanquish UHPLC), and operation of Thermo Orbitrap systems, including an Orbitrap Eclipse Tribrid Fusion MS and an Orbitrap Exploris 240 mass spectrometer. The research program is interested on understanding how the microbiome contributes to human health and susceptibility to infectious disease. The research team collaborates with international partners in Africa, Europe, and Canada.

ESSENTIAL FUNCTIONS

  1. Coordinate laboratory/ research activities with technicians and post-doctoral scholars. Organize experiments and the preparation of samples for metabolite and mass spectrometry analysis. Maintain experimental records on all activities, protocols, data, etc. Ensure laboratory safety. (30%)
  2. Perform the most complex quantitative analytical procedures of a non-routine nature integrating liquid chromatography and mass spectrometry-based tools (metabolomics, proteomics) to study host-microbial interactions in human health. Operate and manage liquid chromatography systems related to metabolomics and proteomics experiments. Execute, analyse, and deliver on assigned research projects. (20%) 
  3. Assist in developing new protocols and techniques for research projects involving a high degree of skill and training. This could include developing/adapting metabolomic/proteomic sample processing protocols for different biological samples, test and optimize workflows for metabolomic/proteomic analysis, etc. (10%)  
  4. Co-author research projects. Participate in manuscript and grant writing, co-author research projects and independently write sponsor progress reports, manuscripts, grant and pilot applications. (10%)
  5. Set up apparatus and perform a wide variety of equipment and standardized procedures.  Oversee/maintain inventory, equipment, and facilities, and recommend purchases. Responsible for environmental safely rules and handling biohazard waste. (10%)

NONESSENTIAL FUNCTIONS 

  1. Teach or instruct others in research techniques. Instruct students, technicians, and post-docs in methodologies, acquisition, and preparation of samples for proteomic/metabolomic analysis. Evaluate adequacy of techniques; study and test new procedures and analyzes data. This could include processing of samples for new experiments, handling data processing and performing data analysis in coordination with Bioinformatics lead. Perform analysis of data from proteomics experiments. (5%)
  2. Supervise students and technicians in standard laboratory policies as well as metabolomic, proteomic, and liquid chromatography research techniques. (5%)
  3. Provide input and recommendation to principal investigator to optimize and troubleshoot procedures to comply with expected outcomes. (5%) 
  4. Participate in weekly research meetings and conferences to present data. May co-author research projects. (3%)
  5. Perform other duties as assigned. (2%)

CONTACTS

Department: Frequent contact with principal investigator for project and lab communication, infrequent contact with department administration.

University: Frequent contact with other university collaborating departments including other basic science departments regarding on-going projects and lab activities.

External: Infrequent contact with vendors, IRB, other collaborating institutions.

Technical, students: Daily contact with students and technicians to explain data, techniques, etc., and to maintain workflow.

SUPERVISORY RESPONSIBILITY

Supervise students, post docs, and technicians

QUALIFICATIONS

Experience: 5 to 8 years of related experience required.

Education/Licensing: Bachelor’s degree required; preferably in Chemistry, Physics, Biotechnology, or related field.

REQUIRED SKILLS

  1. Has knowledge of commonly used concepts, practices, and procedures within metabolomics, chemistry, biochemistry, or related discipline.
  2. Ability to rely on instructions and pre-established guidelines to perform the functions of the job.
  3. Ability to operate laboratory equipment including advanced liquid chromatography systems, Thermo Orbitrap Mass Spectrometers for metabolomics/proteomics
  4. Ability to ensure laboratory safety.
  5. Ability to perform basic laboratory assays.
  6. Must be highly motivated, responsible, dependable and a self-starter. Ability to meet consistent attendance.
  7. Good/strong organization skills: ability to multi-task, prioritize and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through.  
  8. Ability to work with sensitive information and maintain confidentiality. 
  9. Excellent customer service skills: ability to maintain effective working relationships and address the potential and current needs of customers. Ability to work effectively independently and collaboratively within a team. Ability to interact with colleagues, supervisors, and customers face to face.
  10. Effective problem-solving skills; must demonstrate sound judgment and good decision-making. 

WORKING CONDITIONS

The employee will work mostly in Biosafety Level 2 (BSL-2) facilities and will use infectious materials, and general chemicals.  This job will include handling of human biological specimens that may be infected with HIV, malaria, TB, and other pathogens. This position may provide opportunities for international travel and presentations at international conferences.

 

Research Assistant II (Job # 9255) - King Lab

Job Description

POSITION OBJECTIVE

Working under general supervision, the Research Assistant 2 will plan and carry out research assignments of a routine nature that will utilize established research techniques. The research lab studies human malaria parasites, parasitic worms, and SARS-CoV-2. This position will primarily involve research on SARS-CoV-2 but helping with our malaria studies. The studies on SARS-CoV-2 intend to determine the factors that regulate the type antibody responses infected individuals develop to the virus, how long these antibodies persist, and whether they are associated with protection from re-infection or disease. The malaria research projects are to understand the molecular interaction of how malaria parasites invade human erythrocytes with the aim to develop effective malaria vaccines therapeutic monoclonal antibodies.

ESSENTIAL FUNCTIONS

Plan and carry out research activities focusing on developing and executing assays for characterizing of antibodies responses for SARS-CoV-2. Design PCR and multiplex assays, flow cytometry, enzyme-linked immunoassays, and Surface plasmon resonance. Cell culture of pseudo-virus or malaria parasites (48%)
Conduct a series of experiments, including cloning and sequencing genes. Perform genetic manipulation of human, SARS-CoV-2 and malaria genes such as site directed mutagenesis, gene knockouts, and design gene synthesis, and to construct human monoclonal antibodies. (18%)
Collect, analyze, and integrate data into overall experimental objectives. Develop databases to record data and results Evaluate the adequacy of techniques; study and test new procedures. Present research findings and other current research on related topics at laboratory meetings. (10%)
May assist in developing improved techniques, projection methods or procedures. Isolate peripheral blood mononuclear cells from donors as required. (6%)
Maintain certain equipment facilities, and the Magpix machine used for serological assays. (6%)
Oversee inventory. Maintain chemical/biological inventory in compliance with environmental health and safety. Order reagents and supplies. (6%)
Train new staff. Supervise students in bench skills, and contributions to large-scale research projects. (6%)

NONESSENTIAL FUNCTIONS

Perform duties as assigned. (<1%)

CONTACTS

Department: Daily contact with supervisor to discuss updates, results, ideas, and questions. The Research Assistant 2 will contribute to a much larger and highly technical research project, as part of a collaborative effort. Continual communication and guidance are expected

University: Weekly contact with other departments. Weekly lectures with other departments are an important way of staying connected and aware of current research

External: Daily or weekly contact with vendors. Vendors frequently come through the labs to promote their businesses and products

Students: Daily contact with student employees and volunteers. Although our lab does not currently have any new students, if we did recruit any, this position would assist in mentoring the students

SUPERVISORY RESPONSIBILITY

This position has no direct supervision of staff employees. This position will be training and supervising new students.

QUALIFICATIONS

Education and experience: Bachelor's degree and 1 to 3 years of molecular biology or related experience or Associate's degree in an approved biotechnology program and 2 to 4 years of experience.  

REQUIRED SKILLS

Must be hard-working, flexible, quick thinking, organized, communicative, able to multitask, able to learn the research, take initiative, work with many different people from different countries and backgrounds, able to keep up with a demanding, but positive and interactive work environment.
Has knowledge of commonly-used concepts, practices, and procedures within molecular biology, biochemistry, and immunology or be able to derive information from background reading and lab meetings and learn quickly. Prefer some background in malaria parasite culture, tissue culture, and ELISA assays.
Ability to rely on instructions, pre-established guidelines, and protocols to perform the functions of the job. If a protocol is not provided, a person must be able to research, understand, and troubleshoot protocols with some degree of independence.
Ability to operate laboratory equipment.
Experience in data analysis and navigating various analysis software systems is a plus.
Communicate effectively. Ability to interact with colleagues, supervisors, and customer face to face.
Ability to remain flexible while working under pressure.
Ability to meet consistent attendance.

WORKING CONDITIONS     

The laboratory environment is categorized biosafety level 2. We work with malaria, E.coli, and SARS-CoV-2 pseudoviruses (not live), human cell culture. We only use samples from Covid-19 patients that have been appropriate inactivated if collected from individuals presenting with acute disease before they can be used in our laboratory. Formaldehyde is kept and used infrequently. We have an appointed safety officer who trains all lab members on all necessary information and precautions. Additionally, there is a mandatory training in lab safety and blood borne pathogens issued by Case Western Reserve University. May lift up to 24 lbs.

 



COVID Vaccination

Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information go to: https://case.edu/equity/covid-19-accommodations. Applicants may contact the Office of Equity at 216-368-3066 or equity@case.edu for information regarding religious or medical exemptions as an accommodation.

 

For more information about CWRU employment, go to CWRU's Human Resources page (Note: faculty positions are not posted there)