Mark Cohen, MD

Department of Pathology
School of Medicine
Department of Neurology
School of Medicine
National Prion Diseases Pathology Surveillance Center

Research Information

Research Interests

  • Neuropathology of Prion diseases
  • Neuromuscular diseases

External Appointments

Neuropathology Core Director
Cleveland Alzheimer's Disease Research Center


  • Zhang W, Orrú CD, Foutz A, et al. Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases. Acta Neuropathol. 2024;147(1):17. Published 2024 Jan 17. doi:10.1007/s00401-023-02661-2
  • Wang P, Lynn A, Miskimen K, et al. Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease. Alzheimers Dement. Published online January 7, 2024. doi:10.1002/alz.13655
  • Kerner C, Kotobelli K, Appleby BS, Cohen ML, Abboud H. Pathological findings in autoimmune encephalitis autopsy specimens from cases of suspected prion disease. J Neurol. 2024;271(1):446-456. doi:10.1007/s00415-023-12003-7
  • Cracco L, Cali I, Cohen ML, et al. Efficient transmission of human prion diseases to a glycan-free prion protein-expressing host. Brain. Published online November 24, 2023. doi:10.1093/brain/awad399
  • Hromadkova, L., Kim, C., Haldiman, T. et al. Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau. Cell Biosci 13, 174 (2023)
  •  Venkatraghavan, V, Pascuzzo, R, Bron, EE, et al. A discriminative event-based model for subtype diagnosis of sporadic Creutzfeldt-Jakob disease using brain MRI. Alzheimer's Dement. 2023; 19: 3261–3271.
  • Kim C, Haldiman T, Kang SG, Hromadkova L, Han ZZ, Chen W, Lissemore F, Lerner A, de Silva R, Cohen ML, Westaway D, Safar JG. Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer's disease. Sci Transl Med. 2022 Jan 5;14(626)
  • Liu H, Kim C, Haldiman T, Sigurdson CJ, Nyström S, Nilsson KPR, Cohen ML, Wisniewski T, Hammarström P, Safar JG. Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease. J Biol Chem. 2021 Nov;297(5):101267.
  • Rhoads DD, Wrona A, Foutz A, Blevins J, Glisic K, Person M, Maddox RA, Belay ED, Schonberger LB, Tatsuoka C, Cohen ML, Appleby BS. Diagnosis of prion diseases by RT-QuIC results in improved surveillance. Neurology. 2020 Aug 25;95(8):e1017-e1026. doi: 10.1212/WNL.0000000000010086. Epub 2020 Jun 22. PMID: 32571851.
  • Cali I, Puoti G, Smucny J, Curtiss PM, Cracco L, Kitamoto T, Occhipinti R, Cohen ML, Appleby BS, Gambetti P. Co-existence of PrPD types 1 and 2 in sporadic Creutzfeldt-Jakob disease of the VV subgroup: phenotypic and prion protein characteristics. Sci Rep. 2020 Jan 30;10(1):1503. doi: 10.1038/s41598-020-58446-0. PMID: 32001774; PMCID: PMC6992672.


Doctor of Medicine
Cornell University Medical College
Bachelor of Arts
Cornell University, College of Arts and Sciences

Residencies, Internships and Fellowships

Fellowship in Neuropathology
University Hospitals of Cleveland
Residency in Anatomic and Clinical Pathology
Cornell University
Intership in Internal Medicine
Cornell University