Marta Couce, MD, PhD

Department of Pathology
School of Medicine
Department of Ophthalmology and Visual Sciences
School of Medicine
Tissue Resources
Case Comprehensive Cancer Center

Research Information

Research Interests

  • Neurometabolic 
  • Gliomas


1. Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsan J, Eberhardt NL, Kulig E, Lloyd RV. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab. 1999 Aug;84(8):2903-11.

2. Burguera B, Couce ME, Long J, Lamsam J, Laakso K, Jensen MD, Parisi JE, Lloyd RV. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology. 2000 Mar;71(3):187-95.

3. Burguera B, Couce ME, Curran GL, Jensen MD, Lloyd RV, Cleary MP, Poduslo JF. Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes. 2000 Jul;49(7):1219-23.

4. Couce ME, Aker FV, Scheithauer BW. Chordoid meningioma: a clinicopathologic study of 42 cases. Am J Surg Pathol. 2000 Jul;24(7):899-905. Erratum in: Am J Surg Pathol 2000 Sep;24(9):1316-7.

5. Burguera B, Couce ME. Leptin access into the brain: a saturated transport mechanism in obesity. Physiol Behav. 2001 Nov-Dec;74(4-5):717-20.

6. Couce ME, Green D, Brunetto A, Achim C, Lloyd RV, Burguera B. Limited brain access for leptin in obesity. Pituitary. 2001 Jan-Apr;4(1-2):101-10. Review.

7. Ozolek JA, Finkelstein SD, Couce ME. Gliosarcoma with epithelial differentiation: immunohistochemical and molecular characterization. A case report and review of the literature. Mod Pathol. 2004 Jun;17(6):739-45.

8. Mohan D, Finkelstein SD, Swalsky PA, Sasatomi E, Wiley C, Hamilton RL, Lieberman F, Couce ME. Microdissection genotyping of gliomas: therapeutic and prognostic considerations. Mod Pathol. 2004 Nov;17(11):1346-58.

9. Ionescu DN, McFadden K, Unni KK, Couce ME. Pathologic quiz case: a 33-year-old woman with a large temporal mass. Chondroblastoma of the skull. Arch Pathol Lab Med. 2005 Apr;129(4):539-40.

10. Couce ME, Cottam D, Esplen J, Teijeiro R, Schauer P, Burguera B. Potential role of hypothalamic ghrelin in the pathogenesis of human obesity. J Endocrinol Invest. 2006 Jul-Aug;29(7):599-605.

11. Burguera B, Brunetto A, Garcia-Ocana A, Teijeiro R, Esplen J, Thomas T, Couce ME, Zhao A. Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways. Med Sci Monit. 2006 Nov;12(11):BR341- 9. 13.

12. Couce ME, Medina-Flores R, Wong M, Chu CT. Occult germ cell tumour presenting as spontaneous intracerebral haemorrhage. Histopathology. 2007 May;50(6):789-93

13. Gene AH, Gardner PA, Couce Matovelle ME. Rapidly expanding brain mass. Transpl Infect Dis. 2007 Sep;9(3):211-3.

14. Santandreu FM, Brell M, Gene AH, Guevara R, Oliver J, Couce ME, Roca P. Differences in mitochondrial function and antioxidant systems between regions of human glioma. Cell Physiol Biochem. 2008;22(5-6):757-68.

15. Brell M, Ibáñez J, Felpete A, Burguera B, Frontera M, Couce ME. Quantitative analysis of matrix metalloproteinase-2 mRNA expression in central and peripheral regions of gliomas. Brain Tumor Pathol. 2011 Apr;28(2):137-44.


Doctor of Medicine
Universidad de Santiago de Compostela

Residencies, Internships and Fellowships

Fellowship in Neuropathology
Mayo Clinic
Fellowship in Surgical Pathology
Mayo Clinic
Fellowship in Neuropathology
Mayo Clinic
Research Fellowship in Endocrinology
Mayo Clinic
Anatomic Pathology
Yale New Haven Hospital