Shulin Zhang, MD, PhD

Adjunct Associate Professor
Department of Pathology
School of Medicine

Dr. Zhang earned his M.D. from Beijing Medical University, China. He completed his Ph.D. study in Molecular Genetics at University of Victoria, Canada in 2001. He conducted his 3-year post-doctoral research on stem cell genetics at University of Toronto. In 2007, Dr.Zhang finished his fellowship training in clinical molecular genetics at Queen's University, Canada. In 2009, Dr.Zhang joined University Hospitals Case Medical Center (UHCMC) as the scientific director of molecular diagnostic lab. Dr.Zhang is also an assistant professor at the Department of Pathology, Case Western Reserve University. Dr.Zhang is certified clinical molecular geneticist by American Board of Medical Genetics and Canadian College of Medical Genetics.

Before joining UHCMC, Dr.Zhang was the assistant director of mitochondrial diagnostic laboratory and assistant professor at the Department of Molecular and Human Genetics, Baylor College of Medicine.

Research Information

Research Interests

  1. Molecular diagnosis using high-throughput platforms
  2. Genotype-phenotype correlation analysis

External Appointments

Title
Co-Leader, Center for Precision Diagnostics, Department of Pathology and Laboratory Medicine
Organization/Publication
University Hospitals

Publications

Curtis R.Coughlin II, Ian D. Krantz, Eric S. Schmitt, Shulin Zhang, Lee-Jun C.Wong, Douglas S.Kerr, Jaya Ganesh. Somatic Mosaicism for PDHA1 Mutation in a Male with Pyruvate Dehydrogenase Complex Deficiency. Mol Genet Metab. 2010 Jul;100(3):296-9. doi: 10.1016/j.ymgme.2010.04.004. Epub 2010 Apr 14.

Shulin Zhang, Ph.D., Fang-yuan Li, Ph.D., Harold N Bass, M.D., Amber Pursley, M.Sc., Eric S Schmitt, Ph.D., Blaire L Brown, M.Sc., Ellen K Brundage, B.A., Rebecca Mardach, M.D. Lee-Jun Wong Ph.D. Application of Oligonucleotide Array CGH to the Simultaneous Detection of a Deletion in the Nuclear TK2 Gene and mtDNA Depletion. Molecular Genetics and Metabolism 2010, 99(1):53-57.

Ayman W. El-Hattab, Fang-Yuan Li, Eric Schmitt, Shulin Zhang, William J. Craigen, Lee-Jun C. Wong. MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations. Molecular Genetics and Metabolism 2010Mar; 99(3):300-8

Aziz Shaibani, Oleg Shchelochkov, Shulin Zhang, Panagiotis Katsonis, Olivier Lichtarge, Lee-Jun Wong, Marwan Shinawi, Mitochondrial Neurogastrointestinal Encephalopathy Due to Mutations in RRM2B. Archives of Neurology 2009, Aug 66(8):1028-32

Nicola Brunetti-Pierri, Aziz Shaibani, Shulin Zhang, Lee-Jun Wong, Marwan Shinawi. Progressive Myopathy with Multiple Symmetric Lipomatosis. Arch Neurol. 2009;66(12):1576-1577

Milone M, Younge BR, Wang J, Zhang S, Wong LJ. Mitochondrial Disorder with OPA1 Mutation Lacking Optic Atrophy. Mitochondrion 2009 Jul; 9(4):279_81

Shannon R. Payne, Shulin Zhang, Karen Tsuchiya, Russell Moser, Kay E. Gurley, Gary Longton, Johan deBoer, and Christopher J. Kemp. p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. Mol Cell Biol. 2008 January; 28(1): 258–268.

Zhang S. Uchida S, Aubin J.E. Side Population (SP) Cells Isolated from Fetal Rat Calvaria are Enriched for Bone, Cartilage, Adipose Tissue and Neural Progenitors Bone 2006 (38):662-670.

Zhang S. Chen M, Aubin J.E. Pleiotropic Effects of Steroid Hormone 1,25-Dihydroxyvitamin D3 on the Recruitment of Mesenchymal Lineage Progenitors in Fetal Rat Calvaria Cells Journal of Molecular Endocrinology 2006 36(3):425-433.

Zhang S. Avulsion "Fracture of Iliac Spine in Athletes", Sports Medicine in Practice, 4th edition, p388-389, China, 2003

Zhang S, Lloyd R, Bowden G, de Boer J.G and Glickman B. W. Thymic Lymphoma Arising in Msh2 Deficient Mice Display a Large Increase in Mutation Frequency and an Altered Mutational Spectrum. Mutation research 2002 Apr. 500 (1-2): 67-74.

Zhang S, Lloyd R, Bowden G, de Boer J.G. and Glickman B. W. Msh2 deficiency increases the mutation frequency in all parts of the mouse colon. Environmental and Molecular Mutagenesis 2002, 40: 243-250.

Zhang S, Lloyd R, Bowden G, de Boer J.G. and Glickman B. W. Synergistic Effect of Msh2 DNA Mismatch Repair Gene Deficiency and a Food Borne Mutagen 2-Amino-1-Methyl-6-Phenolimidazol [4,5-b] Pyridine (PhIP) in the Mutagenesis of Colon. Oncogene 2001 Sep 20;20(42):6066-72.

Zhang S, de Boer J.G. and Glickman B. W. Spontaneous Mutations of LacI Transgene in Rodents: Absence of Strain, Species and Insertion Site Influence. Environmental and Molecular Mutagenesis (2001) 37:141-146.

Education

Degree
Doctor of Medicine
Institution
Beijing Medical University
Degree
Doctor of Philosophy
Institution
University of Victoria
Area of Study
Molecular Genetics
Year Received
2001

Residency

Institution
Queen's University
Area of Study
Fellowship, Clinical Molecular Genetics
Institution
University of Toronto
Area of Study
Post-doctoral Research, Stem Cell Genetics