Protocol Review & Monitoring Committee

Strengthen Your Trial Before Activation

Successful clinical trials require more than an important research question. Studies must be scientifically rigorous, operationally feasible, and positioned for successful accrual and completion.

Through scientific review and ongoing oversight, the Protocol Review & Monitoring Committee (PRMC) works with you to refine your protocol before activation through multidisciplinary scientific feedback focused on study design, feasibility, accrual potential, and overall study performance.

PRMC Review Requirements

PRMC review is required for:

Cancer-related clinical trials involving drugs, devices, or behavioral interventions
Prospective observational studies, including survey-based research
Prospective tissue research studies

How the PRMC Supports Investigators

The PRMC reviews studies to help ensure they:

Address important scientific and clinical questions
Are designed to produce meaningful and impactful results
Are feasible within available patient populations and institutional resources
Complement ongoing research efforts across the consortium
Maintain scientific progress throughout the life of the study

Early scientific review can help investigators identify potential challenges before activation, strengthen protocol design, and improve study readiness.

Ongoing Study Monitoring

The PRMC also monitors active studies for accrual, scientific progress, and overall study performance. Ongoing oversight helps identify enrollment barriers, support effective study execution, and promote responsible use of research resources.

As an NCI-required component of comprehensive cancer centers, the PRMC helps support the quality, integrity, and impact of cancer clinical research across the consortium.

About Case CCC PRMC

Submission & Review Process

Policies & Guidelines

Protocol & Review Form Templates

Contact

Email PRMC@case.edu for further information.