Tables of Cases Examined

 
National Prion Disease Pathology Surveillance Center Cases Examined¹

Updated quarterly.
Last updated on: September 2nd, 2023

Year Total Neuropath Referrals² Prion Disease Sporadic Genetic Iatrogenic vCJD
1999 & earlier 383 232 202 27 3 0
2000 145 102 90 12 0 0
2001 209 118 110 8 0 0
2002 241 144 124 18 2 0
2003 259 160 137 21 2 0
2004 315 180 163 16 0 1³
2005 330 179 157 21 1 0
2006 365 179 159 17 1 2
2007 374 210 191 19 0 0
2008 384 221 205 16 0 0
2009 397 231 210 20 1 0
2010 402 247 219 28 0 0
2011 392 238 214 24 0 0
2012 413 244 221 23 0 0
2013 416 258 223 34 1 0
2014 355 208 185 21 1 1
2015 401 262 243 19 0 0
2016 395 277 248 29 0 0
2017 375 266 247 18 0 0
2018 308 221 202 18 1 0
2019 434 281 259 22 0 0
2020 367 253 228 24 1 0
2021 344 248 224 22 0 0
2022 337 228 206 21 0 0
2023 193 114 101 8 0 0
TOTAL 85346 53017 47208 5079 14 4
Year CSF Only and RT-QuIC Positive10
2015 140
2016 183
2017 227
2018 266
2019 310
2020 309
2021 331
2022 347
2022 240
TOTAL 2357

1Listed based on the year of death or, if not available, on the year of referral; 
2Cases with suspected prion disease for which brain tissue was submitted; 
3Disease acquired in the United Kingdom; 
4Disease acquired in the United Kingdom in one case and in Saudi Arabia in the other; 
5Disease possibly acquired in a Middle Eastern or Eastern European country; 
6Includes 28 cases in which the diagnosis is pending (from 2022 and 31 from 2023), and 20 inconclusive cases; 
7Includes (2 from 2021, 1 from 2022, and from 2023) cases with type determination pending in which the diagnosis of vCJD has been excluded. 
8The sporadic cases include 4641 cases of sporadic Creutzfeldt-Jakob disease (sCJD), 88 cases of Variably Protease-Sensitive Prionopathy (VPSPr), and 39 cases of sporadic Fatal Insomnia (sFI). 
9Total does not include 312 Familial cases diagnosed by blood test only.
10Lists number of patients (deceased and alive) who have had a positive RT-QuIC and no neuropath examination.


For a downloadable PDF version of our quarterly table, please click the link below: 

NPDPSC Table of Cases Examined