Kenneth Matreyek, PhD

Assistant Professor
Department of Pathology
School of Medicine
Cleveland Center for Membrane & Structural Biology
School of Medicine

Kenneth Matreyek obtained a BSc in Microbiology, Immunology, and Molecular Genetics from the University of California Los Angeles. He earned a PhD in Virology from Harvard University, studying the molecular interactions that HIV uses to enter the nucleus of infected cells before integrating its viral genome. For his postdoctoral training, he joined the Department of Genome Sciences at the University of Washington, where he created genetic methods for high-throughput functional characterization of protein variants in cultured cells. He joined the Department of Pathology at CWRU during the fall of 2019, where he leads an interdisciplinary research group developing new biotechnologies for performing large-scale genetic experiments assessing protein functions within cells.

Research Information

Research Interests

The Matreyek Lab seeks to understand how protein sequence variants contribute to disease. We specialize in using mammalian synthetic biology to create multiplex genetic assays that allow large-scale assessments of protein function in cultured cells. Major research interests include 1) Characterization of missense variants observed in patients, either as germline or somatic variants, 2) Infectious disease / viral biology, such as the understanding of protein ortholog compatibilities required for cross-species transmission, 3) Systematic characterization of peptide motifs and protein domains that dictate cell biology, 4) Identification of missense variants that impact drug metabolism, 5) Deciphering the range of functional sequence space accessed by immune mechanisms, 6) Directed evolution for the creation of novel protein sequences.

For more information, please visit the lab website: