Dr. Wenzhang Wang received his Ph.D. from Fudan University in China in 2011 and then joined the Department of Pathology at Case Western Reserve University for postdoctoral training. He was promoted to Instructor of Pathology in 2017 and Assistant Professor of Pathology in 2020.
We are interested in the pathogenesis of neurodegenerative diseases with the focus on the mitochondrial dysfunctions. We utilize the cell culture in vitro and transgenic rodent in vivo models to explores the mechanisms underlying abnormal mitochondria and disturbed brain homeostasis.
Mitochondria are instrumental in maintaining human brain homeostasis, and disturbed mitochondria associate with neuronal dysfunction and related pathology in neurodegenerative diseases including Alzheimer’s Disease (AD) and Parkinson’s disease (PD). Dr. Wang’s research focuses on mitochondrial abnormalities and related mechanisms underlying the pathogenesis of these diseases.
Current projects include:
- The role of mitochondrial proteostasis in AD
- The apolipoprotein and mitochondrial dysfunction in AD
- Mitochondrial metal homeostasis in neurodegenerative diseases