Prion Disease is currently an invariably fatal condition without treatment or cure. Despite multiple prior treatment studies, including quinacrine, doxycycline, and pentosan polysulfate, no investigational treatments have benefited patients with prion disease. However, new treatments are currently being investigated. This site will be regularly updated with available treatment trial information for prion disease.
Below is a list of clinical research studies for prion diseases.
For additional information about each study, including eligibility criteria, study locations, and enrollment details, please visit the linked ClinicalTrials.gov pages.
Clinical Trials
Clinical Trial | ClinicalTrials.gov Page | Status | Status | Community Statement |
|---|---|---|---|---|
| PrP-targeting siRNA Safety & Mechanism Study (PRiSM) | Recruiting | N/A | ||
| ION717-CS2: A Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION717 in Patients with Prion Disease | Not Recruiting | Not Recruiting |
Observational Studies
Clinical Trial | ClinicalTrials.gov Page | Status | Status | Community Statement |
|---|---|---|---|---|
| Teleneurology Assessment Program for Creutzfeldt-Jakob Disease (TAPCJD) | Recruiting | N/A | Pending | |
| PROSPECT Registry for Individuals at Risk for Genetic Prion Disease (PROSPECT) | Not Recruiting | N/A | Pending |