NPDPSC Table of Cases Examined

 

Updated quarterly.
Last updated on: December 2nd, 2024

Year Total Neuropath Referrals2 Prion Disease Sporadic Familial iCJD vCJD
1999 & earlier 384 232 202 27 3 0
2000 145 102 90 12 0 0
2001 209 118 110 8 0 0
2002 241 144 124 18 2 0
2003 259 160 137 21 2 0
2004 315 180 163 16 0 13
2005 330 179 157 21 1 0
2006 365 179 159 17 1 24
2007 374 210 191 19 0 0
2008 384 221 205 16 0 0
2009 397 231 210 20 1 0
2010 402 247 219 28 0 0
2011 392 238 214 24 0 0
2012 413 244 221 23 0 0
2013 416 258 223 34 1 0
2014 355 208 185 21 1 15
2015 401 262 243 19 0 0
2016 396 278 247 30 0 0
2017 376 266 247 19 0 0
2018 311 221 202 18 1 0
2019 437 281 259 22 0 0
2020 367 253 228 24 1 0
2021 345 248 226 22 0 0
2022 341 229 208 21 0 0
2023 327 237 216 18 1 0
2024 306 206 170 12 0 0
TOTAL 8,9886 5,6327 5,0568 5309 9 4

 

Year CSF Only & RT-QuIC Positive10
2015 139
2016 187
2017 227
2018 265
2019 309
2020 308
2021 328
2022 340
2023 323
2024 274
TOTAL 2700

1 Listed based on the year of death or, if not available, on the year of referral;
2 Cases with suspected prion disease for which brain tissue and/or blood (in familial cases) were submitted. Includes 22 autopsy coordinated cases pending tissue receipt;
3 Disease acquired in the United Kingdom;
4 Disease acquired in the United Kingdom in one case and Saudi Arabia in the other;
5 Disease possibly acquired in a Middle Eastern or Eastern European country;
6 Includes 35 cases in which the diagnosis is pending (1 from 1961, 1 from 2016, 2 from 2023 and 25 from 2024), and 20 inconclusive cases;
7 Includes 27 (1 from 2016, 2 from 2023, and 24 from 2024) cases with type determination pending in which the diagnosis of vCJD has been excluded.
8 The sporadic cases include 4,923 cases of sporadic Creutzfeldt-Jakob disease (sCJD), 92 cases of Variably Protease-Sensitive Prionopathy (VPSPr), and 41 cases of sporadic Fatal Insomnia (sFI).
9 Total does not include 324 Familial cases diagnosed by blood only.
10Number of positive RT-QuIC cases for which we have not received tissue.

For a downloadable PDF version of our quarterly table, please click the link below: 

NPDPSC Table of Cases Examined