Mendel E. Singer, PhD, MPH

Associate Professor
Department of Population & Quantitative Health Sciences
School of Medicine
Vice Chair for Education

Dr. Mendel E. Singer plays a significant role in the department leading the development and promotion of graduate programs, which have grown considerably under his direction. In addition to his oversight and teaching responsibilities, his own methods research focuses on innovative use of electronic health records for evidence based medicine and public health and cost-effectiveness analysis in developing nations. His research has focused on the medical areas of opioid overdose, infectious disease and sexual assault.

Teaching Information

Courses Taught

Statistical Methods in Public Health
Comparative and Cost Effectiveness Research
Biostatistics Module, Physician’s Assistant Program

Research Information

Research Interests

Content Areas

  • Public and population health
  • Infectious disease
  • Opioid overdose
  • Health outcomes research
  • Evidence-based public health and medicine


  • Using electronic health records for health outcomes research
  • Using electronic health records for prevention
  • Using electronic health records for comparative and cost-effectiveness research
  • Cost-effectiveness analysis for public health issues

Professional Memberships

American Public Health Association
American Medical Informatics Association


Selected publications include:  

1.    Singer ME, Taub IB, Kaelber DC. Risk of Myocarditis from COVID-19 Infection in People Under Age 20: A Population-Based Analysis. MedRxiv. doi: Metrics as of Feb 27, 2022: Altmetric 4,846. 62 news outlets linked to article. 6,790 tweets linked to article. 28 citations. Reviewed in a CDC COVID Weekly Science Update.
2.    Singer ME, Kaelber DC, Antonelli MJ. Hydroxychloroquine ineffective for COVID-19 prophylaxis in lupus and rheumatoid arthritis. Annals of the rheumatic diseases. August 2020. doi:10.1136/annrheumdis-2020-218500.
3.    Lovell RE, Singer ME, Flannery DJ, McGuire MJ. The case for “investigate all”: Assessing the cost-effectiveness of investigating no CODIS hit cases in a sexual assault kit initiative. Journal of forensic sciences. 2021;66(4):1316-1328. doi:10.1111/1556-4029.14686
4.    *Deo VS, Gilson TP, Kaspar C, Singer ME. The fentanyl phase of the opioid epidemic in Cuyahoga County, Ohio, United States. Journal of forensic sciences. 2021;66(3):926-933. doi:10.1111/1556-4029.14665
5.    Singer ME, Smith MS. Wide Area Transepithelial Sampling with Computer-Assisted Analysis (WATS 3D ) Is Cost-Effective in Barrett’s Esophagus Screening. Digestive diseases and sciences. 2021;66(5):1572-1579. doi:10.1007/s10620-020-06412-1.
6.    *Ward, MC, Shah, C, Adelstein, DJ, Geiger, JL, Miller, JA, Koyfman, SA, Singer, ME. Cost-effectiveness of nivolumab for recurrent or metastatic head and neck cancer. Oral Oncol. 2017;  74 : 49-55. PubMed PMID: 29103751.
7.    *Slaughter ME, Farris C, Singer M, Smyth KA, Singer ME. Using claims data to examine hospital readmission risk in patients with schizophrenia and comorbid marijuana use disorders. Journal of Studies on Alcohol and Drugs. 2017 Mar;78(2):278-286.  PMID: 28317509
8.    *Musuuza JS; Singer ME; MandalakasA; Katamba A. Key actors’ perspectives on cost-effectiveness analysis in Uganda: a cross-sectional survey. BMC Health Services Research [BMC Health Serv Res], ISSN: 1472-6963, 2014 Nov 4; Vol. 14 (1), pp. 539. PMID: 25363234
9.    *Kagaayi  J; Gray RH; Whalen C; Fu P; Neuhauser D; McGrath JW; Sewankambo NK; Serwadda D; Kigozi G; Nalugoda F; Reynolds SJ; Wawer MJ; Singer ME. Indices to measure risk of HIV acquisition in Rakai, Uganda. PLoS One. 2014 Apr 04; Vol. 9 (4), pp. e92015. Date of Electronic Publication: 20140404 (Print Publication: 2014).  PMCID: PMC3976261
10.    Younossi ZM, Singer ME, Mir HM, Henry L, Hunt S. Impact of Interferon Free Regimens on Clinical and Cost Outcomes for Chronic Hepatitis C Genotype 1 Patients. Journal of Hepatology. 2014 Mar; Vol. 60 (3), pp. 530-7. PMID: 24269472
11.    *Mupere E, Schiltz N, Mulogo E, Katamba A, Sekandi NJ, Singer ME. Cost-Effectiveness of Active Case-finding strategies in Tuberculosis Control in Kampala, Uganda. Accepted. International Journal of Tuberculosis and Lung Disease. 2013;17(2):207-13.  PMID: 23317956
12.    Asche CV, Singer ME, Jhaveri M, Chung H, Miller A. All-cause health care utilization and costs associated with newly diagnosed multiple sclerosis in the United States. J Manag Care Pharm. 2010;16(9):703-12. PMID: 21067256
13.    *Babigumira JB, Sethi AK, Smyth KA, Singer ME. Cost-Effectiveness of Programmatic Models to Provide Antiretroviral Therapy in Resource-Limited Settings. PharmacoEconomics 2009; 27(11): 963-973. PMID: 19888795
14.    * Rose J, Hawthorn RL, Watts B, Singer ME. Public health impact and cost effectiveness of mass vaccination with live attenuated human rotavirus vaccine (RIX4414) in India: model based analysis. BMJ 2009;339:b3653. ; PMCID: PMC2752498
15.    *Rose J, Singer ME.  Projecting vaccine efficacy: accounting for geographic strain variations PharmacoEconomics. 2008;26(3): 185-189.  PMID: 18282014
16.    *Barzilai DA, Singer ME. Potential impact of an intervention to reduce rates of insufficient excision margins for malignant melanoma. Journal of Investigative Dermatology. 2003;120(6): 1067-72. 12787136 PMID: 12787136
17.    Singer ME, Harding I, Jacobs MR, Jaffe DH. Impact of antimicrobial resistance on health outcomes in the outpatient treatment of adult community-acquired pneumonia: a probability model. J Antimicrob Chemotherapy. 2003; 51, 1269-1282. PMID: 12697646



Operations Research
Case Western Reserve University
Case Western Reserve University
Operations Research
Case Western Reserve University
Rutgers University

Additional Information


Student and mentee totals, over Case Western Reserve University career/full academic career:

  • Master’s: Over 500 taught, 54 mentored (11 MS Thesis, 43 MPH Capstone) 
  • PhD: 8 mentored              
  • A sampling of CWRU PhD graduates’ current careers:  
    • University of Washington 
    • World Health Organization
    • Rand Corporation
    • Makerere University School of Public Health
    • Cleveland Clinic
    • University Hospitals of Cleveland
    • Exact Sciences