Dr. Stein also studies HIV-infected individuals that do not develop active TB disease despite being immunosuppressed and living in a highly-exposed, TB-endemic household setting. Dr. Stein and colleagues have recently published a genome-wide association study showing theIL12B gene as a strongly protective gene against TB (Sobota et al. 2016, Am J Hum Genet).
Dr. Stein’s work on tuberculosis resistance is funded by 2 NIH grants and a research grant from the Bill & Melinda Gates foundation.
Sobota RS, Stein CM, Kodaman N, Scheinfeldt LB, Maro I, Wieland-Alter W, Igo RP Jr, Magohe A, Malone LL, Chervenak K, Hall NB, Modongo C, Zetola N, Matee M, Joloba M, Froment A, Nyambo TB, Moore JH, Scott WK, Lahey T, Boom WH, von Reyn CF, Tishkoff SA, Sirugo G, Williams SM. A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals. Am J Hum Genet. 2016 Mar 3;98(3):514-24
Ma N, Zalwango S, Malone LL, Nsereko M, Wampande EM, Thiel BA, Okware B, Igo RP Jr, Joloba ML, Mupere E, Mayanja-Kizza H, Boom WH, Stein CM;Tuberculosis Research Unit (TBRU). Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda. BMC Infect Dis. 2014 Jun 27;14:352.