Rui Wang, PhD

Assistant Professor
Department of Surgery
School of Medicine
Member
GI Cancer Genetics Program
Case Comprehensive Cancer Center

Research Information

Research Interests

Our laboratory aims to understand how the microenvironment mediates cancer cell growth and chemoresistance in colorectal and pancreatic cancers. We established strategies for isolating different cell types from malignant and non-malignant tissues (human and murine) as our working models to identify and validate new targets for developing new anti-neoplastic regimens.

With a focus on metastatic tumors in the liver, we determined that liver endothelial cells (ECs, represent over 50% of stromal cells in the liver) promote cancer cell survival by secreting soluble factors in a paracrine fashion (angiocrine). We also determined that HER3 (also known as ERBB3) is one of the major mediators of the EC-induced cancer cell survival and is potentially activated via a previously unknown mechanism (independent of other HER receptors and the identified HER3 ligands neuregulins).

Current focus:

  • Determine the mechanism of EC-induced HER3 activation (EC-secreted new HER3 ligands)
  • Characterize roles of liver ECs on cancer cell growth, response to chemotherapy, metabolism, and other pro-survival pathways.
  • How other stromal cells in the microenvironment affect cancer cell functions
  • Cancer-stromal cross-talk.

Publications

Education

Doctor of Philosophy
Biochemistry and Cancer Biology
Augusta University
2013
Bachelor of Science
The University of Edinburgh
2007

Residencies, Internships and Fellowships

Postdoctoral fellowship in colorectal cancer research
The University of Texas MD Anderson Cancer Center
2019