Associate Professor
Frances Payne Bolton School of Nursing
Member
Population and Cancer Prevention Program
Case Comprehensive Cancer Center
Teaching Information
Teaching Interests
- Translational Research
- Symptom Management
- Oncology Nursing
Research Information
Research Interests
- Cancer patient symptom management
- Molecular-genetic mechanisms of cancer-related fatigue
- Mitochondrial bioenergetic mechanisms of radiation-induced fatigue
Research Projects
Completed
Mitochondrial Bioenergetic Mechanism of Cancer Related Fatigue
Principal Investigator: Chao-Pin Hsiao, PhD, RN
Funding Agency: NIH, National Institute of Nursing Research (K01)
Period: 08/2015-05/2018
- This study examine the association among certain genes, mitochondrial bioenergetics, and fatigue in prostate cancer patients receiving localized radiation therapy over a period of time and to compare differences in gene expression, the mitochondrial bioenergetics profile, and fatigue between the patients with radiation therapy and without radiation therapy (on active surveillance).
Mitochondrial Bioenergetic Mechanism and Cancer Related Fatigue in prostate Cancer: Bridge the Essential Knowledge and Skills of Mitochondrial Bioenergetics
Principal Investigator: Chao-Pin Hsiao, PhD, RN
Funding Agency: ACES+ ADVANCE Opportunity Grant, Case Western Reserve University
Period: 03/2016-03/2017
- This grant supports travel to another facility to obtain essential and advanced training program in mitochondrial metabolism and bioenergetics, developing successful competitive research proposals integrating bench science, clinical practice, and novel interventions, stemming from a molecular-genetics perspective of symptom management in cancer.
Changes in Mitochondrial Bioenergetics and Cancer-Related Fatigue in Prostate Cancer
Principal Investigator: Chao-Pin Hsiao, PhD, RN
Funding Agency: Oncology Nursing Society Foundation (RE01)
Period: 01/2014-01/2016
- This is a pilot study exploring mitochondrial functions and fatigue experience in patients receiving localized radiation therapy. It focuses on establishing laboratory procedures and baseline data.
Relationship between Mitochondrial Dysfunction and Fatigue in Cancer Patients Following External Beam Radiation Therapy
Principal Investigator: Chao-Pin Hsiao, PhD, RN
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 05/2009-01/2014
- (10-NR-0088) This study explored changes in the expression of mitochondrial genes that are associated with fatigue symptoms of prostate cancer patients receiving localized radiation therapy.
Investigating Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy
Role: Lead Associate Investigator
Principal Investigator: L. Saligan, PhD, RN, FAAN
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 05/2010-01/2014
- (10-NR-0088) This study explored explores the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, and psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT).
Investigating Correlates of Fatigue in Cancer Patients Receiving Treatment
Principal Investigator: Chao-Pin Hsiao, PhD, RN
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 06/2011-01/2014
- (10-NR-0014) This study explored explores the molecular-genetic mechanisms underlying fatigue experienced by cancer patients receiving various therapies (e.g. immune therapy, hormone therapy, and chemotherapy).
Awards and Honors
The Junior Research Researcher Award
Midwest Nursing Research Society
Professional Memberships
Member, Midwest Nursing Research Society (MNRS), 2013-present
Member, Oncology Nursing Society, 2003 – present
Member, Sigma Theta Tau, Beta Mu Chapter 2003 – present
Member, International Sigma Theta Tau, 1999 – present
Publications
- Hsiao, C.P., Daly, B., Chen, M. K., Veigl, M., Dorth, J., Ponsky, L. E., & Hoppel, C. (2021). Possible Bioenergetic Biomarker for Chronic Cancer-Related Fatigue. Nurs Res, 70(6), 475-480. https://doi.org/10.1097/nnr.0000000000000547
- Hsiao, C.P., Dickinson K, Gonzalez-Marrero V, Kelly DL, Lukkahatai N, McCabe M, Mayo, S, Musanti R, & Saligan LN (2019). Consortium Building for Nurse Scientists Interested in Symptom Research in the Era of Precision Health. The Journal of Nursing Scholarship. 52(2):183-191.
- Hsiao, C.P., Chen, MK., Veigl, M., Ellis, R., Cooney, M., Daly, B., & Hoppel, C. (2019). Relationships between expression of BCS1L, mitochondrial bioenergetics, and among patients with prostate cancer. Cancer Management and Research. 11, 6703-6717
- Hsiao, C.P., Chen, MK., Daly, B., & Hoppel, C. (2018). Integrated Mitochondrial Function and Cancer-related Fatigue in Men with Prostate Cancer Undergoing Radiation Therapy. Cancer Management and Research. 10, 6367-6377
- Hsiao, C.P. & Hoppel, C. (2018). Analyzing Mitochondrial Function in Human Lymphocytes. Analytical Biochemistry:Methods in the Biological Science, 549, 12-20. †
- Hsiao C.P., Chen M-K, Meyers KJ, Saligan LN (2017). Symptoms predicting health-related quality of life in prostate cancer patients treated with localized radiation therapy. Family Medicine and Community Health. 5(2):119-128.
- Hsiao, C.P., Daly, B., & Saligan, L. (2016). The Etiology and management of radiotherapy-induced fatigue. Expert Review of Quality of Life in Cancer Care, 1(4), 323-328
- Kelly DL, Dickinson K, Hsiao C-P, Lukkahatai N, Gonzalez-Marrero V, McCabe M, Saligan LN (2016). Biological Basis for the Clustering of Symptoms, Seminars in Oncology Nursing, doi:10.1016/j.soncn.2016.08.002
- Hsiao, C.P., Daly, B., & Hoppel, C. (2015). Association between Mitochondrial Bioenergetics and Radiation-related Fatigue: A Possible Mechanism and Novel Target. The Journal of Archives in Cancer Research, 3 (2), 1-9
- Hsiao, C.P., Araneta, M., Reddy, S.Y., Chen, M.-K., & Saligan, L. (2015). Genomic Profile of Fatigued Men While receiving Localized Radiation Therapy. The Journal of Biological Research for Nursing. 2016 May;18(3):281-9. doi: 10.1177/1099800415618786. Epub 2015 Nov 29.
- Feng, R., Chen, M.-K., Lukkahatai N, Hsiao, C.P., Kaushal, A., Lee Sechrest & Saligan, L. (2015). Clinical predictors of fatigue in non-metastatic prostate cancer patients receiving external beam radiation therapy. Journal of Clinical Oncology Nursing, 19 (6), 744-750
- Hsiao, C.P., Wang, D., Kaushal, A., Chen, M.-K., & Saligan, L. (2014). Differential Expression of Genes Related to Mitochondrial Biogenesis and Bioenergetics in Fatigued Prostate Cancer Men Receiving External Beam Radiation Therapy. Journal of Pain and Symptom Management, 48 (6), 1080-90.
- Lukkahatai N, Patel S, Gucek M, Hsiao C.P., Saligan LN. (2014). Proteomic Serum Profile of Fatigued Men Receiving Localized External Beam Radiation Therapy for Non-Metastatic Prostate Cancer. J Pain Symptom Manage, 47 (4), 748-56.
- Hsiao, C. P., Moore, I. M. (Ki), Insel, K.C. & Merkle, C. (2014). Symptom Self-Management Strategies in Localized Prostate Cancer. Journal of Clinical Nursing, 23 (3-4), 440-9.
- Hsiao, C.P., Araneta, M., Wang, X-M., Saligan, L. (2013). The association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response. International Journal of Molecular Science, 14 (8), 19643-57.
- Hsiao, C.P., Wang, D., Kaushal, A., Saligan, L. (2013). Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam radiation therapy. Cancer Nursing, 36 (3), 189-97.
- Saligan LN, Hsiao C.P., Wang D, Wang X, Kaushal A, Citrin D, Barb JJ, Munson PJ, Dionne RA. (2012). Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain, Behavior, and Immunity, 27 (1), 63-70.
- Insel, K.C., Merkle, C. J., Hsiao, C.P., Vidrine, A.N., & Montgomery, D.W. (2012). Biomarkers for Cognitive Aging--Part I: Telomere Length, Blood Pressure and Cognition Among Individuals With Hypertension. Biological Research for Nursing, 14 (2), 124-32.
- Hsiao, C. P., Moore, I. M. (Ki), Insel, K.C. & Merkle, C. (2011). High perceived stress is linked to afternoon cortisol levels and greater symptom distress in patients with Localized Prostate Cancer. Cancer Nursing, 34 (6), 470-78.
Education
Doctor of Philosophy
Injury Mechanisms and Biobehavior
University of Arizona, School of Nursing
Master of Science in Nursing
Oncology
National Taiwan University, School of Nursing
Bachelor of Science in Nursing
National Taiwan University, School of Nursing
Residencies, Internships and Fellowships
Postdoctoral
National Institutes of Health, National Institute of Nursing Research, Symptom Biology Unit, Bethesda, Md.