Chao-Pin Hsiao, PhD, RN, FAAN

Associate Professor
Frances Payne Bolton School of Nursing
Member
Population and Cancer Prevention Program
Case Comprehensive Cancer Center

Teaching Information

Teaching Interests

  • Translational Research
  • Symptom Management
  • Oncology Nursing

Research Information

Research Interests

  • Cancer patient symptom management
  • Molecular-genetic mechanisms of cancer-related fatigue
  • Mitochondrial bioenergetic mechanisms of radiation-induced fatigue

Research Projects

Current

Unraveling the Associations of Molecular-Genetic Bioenergetics and Chemotherapy Induced Fatigue Symptoms in Patients with Breast Cancer” (PI: Chao-Pin Hsiao)  
Funding Agency: NIH, National Institute of Nursing Research (R21)
Period: 08/2022 - 08/2024

  • This study investigates the molecular-genetic pathway of mitochondrial bioenergetics and their association with chemotherapy (CT)-induced cancer-related fatigue (CRF) symptoms experienced by patients with breast cancer receiving CT-containing anthracyclines, compared to those with non-anthracycline-based CT.

Completed

Cancer-related Fatigue: Determine the Mitochondrial Bioenergetic Profile of Persistent Radiation-Induced Fatigue” (PI: Chao-Pin Hsiao)
Funding Agency: VPR Catalyst Award/ Seed Funding, CWRU
Period: 06/2018-06/2019

  • This study investigates mitochondrial bioenergetics mechanisms of radiation-induced persistent fatigue by determining associations between changes in mitochondrial gene expression, bioenergetics, and fatigue in prostate cancer patients 24-months after completion of radiotherapy.

Mitochondrial Bioenergetic Mechanism of Cancer Related Fatigue
(PI: Chao-Pin Hsiao)
Funding Agency: NIH, National Institute of Nursing Research (K01)
Period: 08/2015-06/2018

  • This study examines the association among certain genes, mitochondrial bioenergetics, and fatigue in prostate cancer patients receiving localized radiation therapy over a period of time and to compare differences in gene expression, the mitochondrial bioenergetics profile, and fatigue between the patients with radiation therapy and on active surveillance.

Mitochondrial Gene Expression, Mitochondrial Bioenergetics, and Fatigue in Patients with Prostate Cancer (PI: Chao-Pin Hsiao)
Funding Agency: CTSC Core Utilization Pilot Grant, Case Western Reserve University
Period: 04/2017-09/2017

  • This grant supports a subset analysis of mitochondrial-related gene expression providing stronf evidence regarding a hypothesized genomic-molecular mechanism of cancer-related fatigue and mitochondrial bioenergetics, as well as determing biomarkers of mitochondrial bioenergetics for cancer fatigue.

Changes in Mitochondrial Bioenergetics and Cancer-Related Fatigue in Prostate Cancer
(PI: Chao-Pin Hsiao)
Funding Agency: Oncology Nursing Society Foundation (RE01)
Period: 01/2014-01/2016

  • This is a pilot study exploring mitochondrial functions and fatigue experience in patients receiving localized radiation therapy. It focuses on establishing laboratory procedures and baseline data.

Relationship between Mitochondrial Dysfunction and Fatigue in Cancer Patients Following External Beam Radiation Therapy (PI: Chao-Pin Hsiao)
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 05/2009-01/2014

  • This study explored changes in the expression of mitochondrial genes that are associated with fatigue symptoms of prostate cancer patients receiving localized radiation therapy.

Investigating Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy (Role: Lead Associate Investigator; PI: L. Saligan)
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program
Period: 05/2010-01/2014

  • This study explored explores the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, and psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT).

Investigating Correlates of Fatigue in Cancer Patients Receiving Treatment (Role: Lead Associate Investigator; PI: L. Saligan)  
Funding Agency: NIH, National Institute of Nursing Research, Intramural Research

Period: 06/2011-01/2014

  • Program. This study explored explores the molecular-genetic mechanisms underlying fatigue experienced by cancer patients receiving various therapies (e.g., immune and chemotherapy).

Awards and Honors

The Junior Research Researcher Award
Midwest Nursing Research Society

Professional Memberships

Member, Midwest Nursing Research Society (MNRS), 2013-present
Member, Oncology Nursing Society, 2003 – present
Member, Sigma Theta Tau, Beta Mu Chapter 2003 – present
Member, International Sigma Theta Tau, 1999 – present

Publications

Education

Doctor of Philosophy
Injury Mechanisms and Biobehavior
University of Arizona, School of Nursing
Master of Science in Nursing
Oncology
National Taiwan University, School of Nursing
Bachelor of Science in Nursing
National Taiwan University, School of Nursing

Residencies, Internships and Fellowships

Postdoctoral
National Institutes of Health, National Institute of Nursing Research, Symptom Biology Unit, Bethesda, Md.