Get to know the many mentors who take part in Case Western Reserve University School of Medicine's Medical Scientist Training Program, and learn about their respective research focuses.
*Mentors who are also on the Steering Committee
Biochemistry
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Kaixiang Cao, PhD | Biochemistry | Elucidating mechanisms underlying stem cell differentiation and mammalian development with genetic, epigenetic, and genomic approaches | ||
| Timothy Chan, MD, PhD | Biochemistry | Stephen Wang | The Chan Laboratory specializes in using genomic analysis to characterize the drivers of genetic programs underlying immunotherapy and oncogenesis. These approaches include large-scale analyses, functional genomics, immunogenomics, biochemical and molecular analyses, and mouse modeling. The lab has a special interest in deciphering the mechanisms underlying immunotherapy treatment response, resistance, and mechanisms | |
| J. Alan Diehl, PhD | Biochemistry | Discovery of molecular mechanisms that contribute to uncontrolled cell proliferation and decreased cell death. The first area of focus is cell survival and lipid signaling pathways that are utilized during tumorigenesis. The second area of focus is on the elucidation of mechanisms whereby growth signaling pathways regulate the cell division | ||
| Thomas Gerken, PhD | Biochemistry | Protein structure and dynamics; NMR techniques; molecular modeling of glycoproteins and mucins | ||
| Eckhard Jankowsky, PhD* | Biochemistry, Genetics and Genome Sciences, Pharmacology | Yi Fan Chen, Brendan Sheehan | Sarah Venus, Soon Yi | Single-molecule enzymology (RNA helicases) and single molecule studies of ribonucleoprotein machinery (HCV replication and pre-mRNA splicing) |
| Hung-Ying Kao, PhD | Biochemistry |
Mechanisms of the transcriptional control by diverse signaling pathways; molecular basis of human diseases related to transcriptional regulation |
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| Focco van den Akker, PhD | Pharmacology | Structural biology; infectious diseases/antibiotic resistance; cardiovascular diseases; small-molecule therapeutics design; cell signaling |
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Biomedical Engineering
| Mentor | PhD Programs | MSTP Student Rotation | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| A. Bolu Ajiboye, PhD* | Biomedical Engineering | James Ahad, Morgan McGrath | Anisha Rastogi | Development and control of brain- computer- interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke |
| Jeffrey Capadona, PhD | Biomedical Engineering | Sydney Song | Developing materials to assimilate within the neural tissue to facilitate molecular level connections with individual neurons | |
| Dominique Durand, PhD* | Biomedical Engineering, Neuroscience, Physiology & Biophysics | Sydney Song | Neural engineering, neural prostheses, magnetic and electric stimulation of the nervous system, electrophysiology of epilepsy, computational neuroscience | |
| Robert Kirsch, PhD | Biomedical Engineering | Anisha Rastogi | Mechanics and control of human movement |
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| Xiaojuan Li, PhD | Biomedical Engineering | Novel MR imaging (quantitative MRI, fast MRI) and image analysis (automated tissue segmentation, lesion detection, and prediction of clinical outcomes with deep-learning models). Applications in orthoapedic and rheumatologic disorders including arthritis and sports injury | ||
| Zheng-Rong Lu, PhD | Biomedical Engineering | Walter Zhao | Peter Qiao | Drug delivery and molecular imaging; novel targeting imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; cancer diagnostics and therapeutics; multi-functional delivery systems for nucleic acids and non-viral gene therapy |
| Dan Ma, PhD | Biomedical Engineering | Christina MacAskill, Walter Zhao | Walter Zhao | Fast MR acquisition and reconstruction, MR Fingerprinting, Quantitative MR imaging, Computational Modeling, Novel MR Imaging Technology for Neurological Diseases |
| Anant Madabhushi, PhD | Biomedical Engineering | Jessica Scarborough, Prerna Sigh | Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications. | |
| Andrew Rollins, PhD | Biomedical Engineering | Development and application of advanced optics and photonics technologies for imaging and characterization of biological samples, detection of early disease, and monitoring of therapy in human tissues; and investigating embryonic development | ||
| Anirban Sen Gupta, PhD | Biomedical Engineering, Pathology, Pathology/ Immunology | Michaela Cooley | Our principal research focus is on mechanistic understanding of biological and pathological phenomena at the cellular, sub-cellular and biomolecular levels in hemostasis, thrombosis, thromboinflammation and cancer, and utilization of this knowledge to create bioinspired therapeutic and diagnostic technologies to interrogate, leverage, or treat these various phenomena | |
| Samuel Senyo, PhD | Biomedical Engineering | Natalie Hong, Douglas Wu | The Senyo Group investigates cellular crosstalk in cardiovascular disease to understand disease progression such as in diabetes and to reverse or repair the injured heart. We model the cellular niche using tissue engineering principles and microfabrication. Dr. Senyo performs comparative studies using mammalian model systems, including human stem cells | |
| Andrew Shoffstall, PhD | Biomedical Engineering | Natalie Hong | My research interests lie at the intersection of biomaterials and neural engineering with a particular focus on solutions that may readily translate toward improving the lives of people with neural trauma and other neuropathic and neurodegenerative conditions. | |
| Pallavi Tiwari, PhD | Biomedical Engineering | Benjamin Mittman | To develop Artificial Intelligence and Machine Learning strategies towards personalized diagnostics, prognostics, and treatment evaluation for neurological disorders. Specifically, in the context of applications in adult and pediatric brain tumors | |
| Horst von Recum, PhD* | Biomedical Engineering | Natalie Hong | Creation of novel polymeric platforms for drug delivery and tissue engineering | |
| Satish Viswanath, PhD | Biomedical Engineering | Developing medical image analysis and machine learning tools for imaging data, through spatial correlation and cross-linking against pathology or molecular data | ||
| David Wilson, PhD | Biomedical Engineering | Brian Fort | Clinical and preclinical detection and characterization of cardiovascular disease, ophthalmological conditions, and cancer using biomedical image analysis and learning systems. Techniques used include segmentation, machine learning, registration, etc., as applied to multiple modalities (e.g., OCT, MRI, CT) |
Cardiovascular Research Institute
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Mukesh Jain, MD | Physiology & Biophysics, Pathology | Michaela Cooley, Himanshu Dashora, Erik Koritzinsky, Jennings Luu, Sabrina Wang |
Liyan Fan, Alexander Lesser, David Sweet |
* Not currently accepting MSTP students for rotation or PhD placement |
| Ganapati Mahabaleshwar, PhD | Pathology/Molecular and Cellular Basis of Disease | Transcriptional regulation of inflammatory gene programs in health and disease |
Center for Clinical Investigation
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Michael Rothberg, MD, MPH | Clinical Translational Science | Benjamin Mittman |
Dr. Rothberg’s research examines healthcare quality and decision making for common conditions, with an emphasis on tailoring treatment based on individual risk and preferences. The goal is to help physicians and patients make better decisions, improve outcomes and control costs. |
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| Satya Sahoo, PhD | Epidemiology & Biostatistics | (Biomedical Informatics and Brain Connectivity in Neurological Disorders) We study the underlying mechanisms of neurological disorders such as Epilepsy and Movement Disorder (PD) using computational and mathematical models of brain structural and functional networks as they evolve during disease progression. We are also interested in understanding how clinical events in neurological disorders affect higher order brain functions such as consciousness state and memory. In addition to theoretical models, we have developed Big Data analytic techniques such as Apache Spark libraries to process and analyze large scale data. |
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| James Spilsbury, PhD, MPH* | Epidemiology & Biostatistics, Clinical Translational Science | * Not currently accepting MSTP students for rotation or PhD placement |
Center for Global Health & Diseases
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| James Kazura, MD | Pathology/ Immunology | Emily Hannon | Immunoregulatory mechanisms of pathogenesis; acquired resistance to infection; malaria |
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| Christopher L King, MD, PhD | Pathology/ Immunology | T cell differentiation, Malaria Schistosomiasis, Filariasis Neonatal immunity, IgE regulation Mechanisms of acquired immunity |
Center for Proteomics & Bioinformatics
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Mark Chance, PhD | Genetics and Genome Sciences, Systems Biology & Bioinformatics, Pathology/Immunology, Structural Biology and Biophysics | Dan Jindal | Systems Biology, Protein Structure/Function, Cancer, Diabetes |
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| John Tilton, MD | Molecular Virology | Thomas Lavin | Thomas Lavin | NanoPOD platform for in vivo delivery of protein and RNA therapeutics; HIV-related research using nanoscale flow cytometry to understand viral heterogeneity and its impact on disease; unraveling the mechanisms through which extracellular vesicles fuse with host cells and deliver internal cargos |
Center for RNA Molecular Biology
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Kristian Baker, PhD | Biochemistry, Genetics & Genome Sciences | Joel Sax | Mechanisms of nonsense-medated mRNA decay; Mechanisms of mRNA quality control; translation regulation; post transcriptional gene expression | |
| Donny Licatalosi, PhD | Biochemistry, Systems Biology & Bioinformatics, Genetics and Genome Sciences | Susie Suh, Xinrui Zhang | Understanding how different RBPs regulate gene expression during mouse spermatogenesis, using genetic, bioinformatic, biochemical, and high throughput methods |
Chemistry
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Blanton Tolbert, PhD | Molecular Virology | Erin Cohn | Understanding the molecular mechanisms RNA viruses use to express their genomes |
Cleveland Clinic Lerner Research Institute
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Jay Alberts, PhD | Biomedical Engineering | Morgan McGrath | How the brain controls skilled movements, how changes in brain function affect movement performance; Parkinson's disease, stroke, and concussion; improving movement and cognitive performance; concussion and mild dramatic brain injury | |
| Cornelia Bergmann, PhD | Neurosciences | Brendan Boylan | Currently not taking students | |
| Charis Eng, MD, PhD | Genetics & Genome Sciences, Pathology/ Molecular and Cellular Basis of Disease, Pathology/ Cancer Biology | Ryan Gimple | Cancer genomic medicine translational research; characterization of disease risks in inherited predisposition to cancer; intracytoplasmic trafficking of PTEN and oxidative stress in cancer | |
| Robert Fairchild, PhD* | Pathology/ Immunology | Liyan Fan, Claire Mazahery, Otis Pinkard, Sabrina Wang |
Erik Koritzinsky |
T-lymphocyte tolerance, transplantation immunology; T-cell mediated responses in the skin |
| Stanley Hazen, MD, PhD | Cell Biology, Pathology, Systems Biology & Bioinformatics | Marc Ferrell | A long term goal of my laboratory is to understand new mechanisms linking inflammation and the gut microbiome to cardio metabolic diseases. Several major research programs are currently under investigation. One research program focuses on the role of intestinal microbiota to cardiovascular and metabolic diseases. Another focuses on the pharmacological targeting of the gut biome to improve human health and prevent diseases. A final research program focuses on inflammatory and oxidative processes, and their participation in cardiovascular diseases. All research projects rely heavily on initial hypothesis generating studies in human clinical materials, and use of a combination of chemical, analytical and genetic approaches. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, and human clinical investigations | |
| Justin Lathia, PhD |
Pathology/ Cancer Biology |
Diana Chin, Natasha Ingles, Brian Kim | Adam Lauko, Sabrina Wang | Our main focus is how stem cell programs drive tumor progression and therapeutic resistance. To achieve this goal, we have active projects in cell adhesion mechanisms, cell-cell communication, and the interaction between tumor cell and the immune system. We also are developing new methods to track the stem cell state in real time and single-cell cell-fate decisions. We work mainly in malignant brain tumors and have leveraged the lessons learned in these tumors to other tumor types including breast and ovarian |
| Xiaoxia Li, PhD | Pathology/ Immunology | Alicia Aguilar, Muta Abiff, Brendan Barton, Angela Liu, Michelle Pan, Susie Suh | Willie Miller-Little, Vanessa Salazar | * Not currently accepting MSTP students for rotation or PhD placement |
| Laura Nagy, PhD* | Cell Biology, Nutrition, Pathology/ Molecular and Cellular Basis of Disease | Innate immune contributions to alcohol and non-alcoholic induced liver injury, mechanisms of hepatocyte cell death, adipose-gut-liver interactions in alcoholic liver disease, genetic contributions to ALD | ||
| Jacob Scott, MD, DPhil* | Systems Biology & Bioinformatics | Eshan King, Jessica Scarborough, Davis Weaver | "Nothing in biology makes sense except in the light of evolution” applies as much in the clinic as anywhere else. The difference is that our efforts to treat cancer and infectious diseases both speeds up, and direct evolution of the malady to higher fitness peaks than would be achieved in natural settings. Rather than focussing on individual mutations, we use a combination of mathematical models, experimental evolution and data science to study the process of the evolution of resistance itself. | |
| Ganes Sen, PhD | Biochemistry, Molecular Virology, Pathology/ Immunology | Molecular Virology, Mechanism of Interferon Action, Recombinant DNA Technology, Genetic Regulation of Hypertension | ||
| Nima Sharifi, MD* | Pharmacology | Metabolic and molecular mechanisms of resistance to hormonal therapy in advanced prostate cancer | ||
| Jonathan Smith, PhD | Pathology | Cell/molecular biology, biochemistry, and genetics/genomics studies of three areas related to cardiovascular disease: atherosclerosis reverse cholesterol transport, and atrial fibrillation | ||
| Angela Ting, PhD | Systems Biology & Bioinformatics, Genetics and Genome Sciences | Epigenetic gene regulation is important for both normal development and disease states. We pioneer genome-wide technologies and computational tools to interrogate epigenetic patterns as well as investigate the initiation mechanism and function of these patterns to understand their significance in cancer | ||
| Jennifer Yu, MD, PhD* | Pathology/ Cancer Biology | Understanding mechanisms underlying key Glioma stem cell (GSC) tumorigenic properties; uncovering potential therapeutic targets |
Computer Science and Engineering
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Mehmet Koyutürk, PhD | Systems Biology & Bioinformatics | Bioinformatics and computational biology, network biology, analysis of high-throughput biological data |
Family Medicine and Community Health
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Kurt Stange, MD, PhD | Epidemiology & Biostatistics, Clinical Translational Science | Benjamin Mittman | Uriel Kim | The generalist function, primary care practice, practice-based research, cancer prevention and early detection, multi-method research, health promotion, disability prevention, preventive service delivery in primary medical care |
General Medical Sciences (Oncology)
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Seth Field, MD, PhD | Pathology/Cancer Biology | Corynn Appolonia, Kyle Starost | Kyle Starost | Cell biology of cancer, including elucidation of fundamental mechanisms of membrane trafficking at atomic and molecular resolution; discovery of signal transduction pathways that regulate the secretory pathway; and their contribution to oncogenic transformation. We have an ongoing program to develop small molecule inhibitors of Golgi vesicle budding to produce leads for novel cancer therapeutics. Many of our findings are also relevant to understanding viral and metabolic diseases |
| William Schiemann, PhD | Pathology/ Cancer Biology, Pharmacology | Our research seeks to identify the cellular and molecular defects that enable breast cancers to establish and eventually emerge from metatastic dormancy. In addressing these objectives, our research is broad and includes interests in TGF-β and cell signaling, cellular and metabolic plasticity related to CSCs, EMT programs, the noncodinig genome, and telomere maintenance mechanisms |
Genetics & Genome Sciences
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Drew Adams, PhD* | Genetics & Genome Sciences, Pharmacology | Indrani Das, Hannah Kondolf | Yi-Fan Chen, Zita Hubler, Joel Sax | High-throughput screening and other chemical biology approaches to identify and optimize new drug candidates in neurodegenerative diseases, cancer, and other diseases |
| Berkley Gryder, PhD | Genetics & Genome Sciences | Diana Chin, Sameeha Jilani | Diana Chin | The Gryder Laboratory drugs transcription in the 3D epigenome for therapeutic benefit. In pediatric cancers we drug oncogenic transcription factors; in prostate cancer, we use new strategies that target the Androgen Receptor. We study how therapeutics alter biomolecular condensates that form super-enhancer clusters at key disease genes |
| Ann Harris, PhD | Genetics & Genome Sciences | Anniya Gu, Josephine Trichka | Functional genomics of human epithelia. Epithelial tissues are critical to the normal physiology of many organs including the respiratory tract, digestive system, and reproductive tracts. Epithelial malfunction underlies common diseases including genetic disorders such as cystic fibrosis, and also multiple types of cancer. We use state of the art genomics tools to investigate gene regulatory mechanisms, chromatin architecture and associated transcriptional networks at the highest resolution, including in single cells | |
| Peter Harte, PhD | Genetics & Genome Sciences | Epigenetic regulation of chromatin structure and transcription, histone modifying enzymes, Polycomb silencing, genetic control of lifespan and aging | ||
| Thomas LaFramboise, PhD | Genetics & Genome Sciences, Systems Biology & Bioinformatics | Dan Jindal, Andrew Morton, Kathleen Plona | Developing and applying computational tools to identify molecular variants, both inherited and somatic, that contribute to cancer and related diseases in humans | |
| Yan Li, PhD | Genetics & Genome Sciences | Joseph Schindler | Anniya Gu | Li lab applies functional genomic, epigenomic, and single cell genomic tools to dissect genetics of complex diseases, such as obesity and diabetes |
| Hua Lou, PhD | Genetics & Genome Sciences | Alternative RNA processing and its role in disease development | ||
| Helen Miranda, PhD | Genetics & Genome Sciences | Cell autonomous and non-cell autonomous molecular events involved in spinal bulbar muscular atrophy and amyotrophic lateral sclerosis using induced pluripotent stem cell (iPSC) models | ||
| Peter Scacheri, PhD | Genetics & Genome Sciences, Pathology/ Cancer Biology | Melissa Bonner, Rupleen Kaur, Marc Scemama de Gialluly, Joseph Schindler, Stephen Wang | Ellen Hong, Katherine Letai, Andrew Morton, Stephen Wang | Investigation of the epigenetic code in human health and disease |
| Ashleigh Schaffer, PhD | Genetics & Genome Sciences | Erin Cohn, Hans Leier, Soon Yi | Lucie Ahn | Understanding the unique functions of ubiquitously expressed proteins in human brain development and pediatric neurological disease |
| Paul Tesar, PhD* | Genetics & Genome Sciences, Neurosciences | Meghan O'Keefe, Ying Xiong | Kevin Allan, Erin Cohn, Will Wulftange, Jesse Zhan | Stem cell pluripotency and differentiation; developmental neurobiology; developmental genetics |
| Zhenghe John Wang, PhD | Genetics & Genome Sciences, Pathology/Cancer Biology | George Luo | Identifying novel genetic alterations, such as somatic mutations, gene amplifications and deletions, which alter critical gene functions involved in development of colon and gastric cancers | |
| Anthony Wynshaw-Boris, MD, PhD | Genetics & Genome Sciences | Michael Babinchak, Zita Hubler, Kathleen Plona, Avery Sears | Understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system, using mouse models |
Mechanical & Aerospace Engineering
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Umut Gurkan, PhD | Biomedical Engineering | Natalie Hong, Douglas Wu | Himanshu Dashora, William Wulftange | Micro- and nano-scale technologies, cell mechanics, red blood cells, microcirculation, clinical microfluidics, tissue-on-a-chip systems, cell and gene therapies, point-of-care diagnostics, global health, translational research |
Medicine (Cardiovascular Medicine)
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Andrei Maiseyeu, PhD | Biomedical Engineering, Pathology/Molecular and Cellular Basis of Disease | Our research team develops advanced nanotechnology systems to better understand and treat cardiometabolic diseases such as atherosclerosis, thrombosis, heart failure, and cardiomyopathies. We engineer, make, and test sophisticated probes, nano-immunotherapy devices, drug delivery vehicles, and gene therapy vectors that help to investigate the basic biology of the disease as well as to intervene for therapeutic gain. Our technologies address various problems including immunogenicity of therapies and their cost. Our ultimate dream is to pursue clinical translation of technologies invented in our laboratory and help patients suffering from many forms of cardiovascular disease | ||
| Aaron Proweller, MD, PhD | Cell Biology | Colin Stomberski | Molecular pathways regulating vascular development and morphogenesis including the role of Notch signaling in patterning, maturation and contractile function of the arterial vasculature | |
| Diana Ramírez-Bergeron, PhD | Genetics & Genome Sciences, Pathology | Adaptive responses to changes in oxygen tension and the effect on blood cells and vessels; influence of hypoxic responses on the generation of cardiovascular stem/progenitor cells and their differentiation into various cardiovascular cell lineages; hypoxia and bone marrow stem cell niches | ||
| Jonathan Stamler, MD | Biochemistry | Ying Xiong | Zachary Grimmett, Joseph Schindler, Colin Stomberski, Nicholas Venetos | Our focus is on molecular, cellular and physiological aspects of redox biology, with a major emphasis on (1) the functions of nitric oxide in cellular signaling mediated through the post-translational modification of proteins by S-nitrosylation, (2) the enzymes that create and reverse S-nitrosylation to regulate its signaling, and (3) the consequences of dysregulated S-nitrosylations in animal models and in human disease |
Medicine (Gastroenterology and Hepatology)
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Fabio Cominelli, MD, PhD | Pathology/Molecular and Cellular Basis of Disease | Brendan Boylan | Adrian Gomez- Nguyen | Crohn's Disease, General GI, Inflammatory Bowel Disease, Ulcerative Colitis |
Medicine (Hematology and Oncology)
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Afshin Dowlati, MD | Biochemistry, Pathology/Cancer Biology | Interested in the biology and clinical management of lung cancer, with particular emphasis on small cell lung cancer (SCLC). Emphasis on bench-to-bedside drug development utilizing 'omics' discovery approaches and mouse models of lung cancer. | ||
| Sanford Markowitz, MD, PhD | Molecular Biology & Microbiology, Genetics & Genome Sciences, Pathology/ Cancer Biology | Colon cancer genetics | ||
| Shigemi Matsuyama, DVM, PhD | Pharmacology, Pathology/ Cancer Biology | Cancer cell biology, cell death regulation, cell penetrating peptide | ||
| Reshmi Parameswaran, PhD | Pathology/ Immunology, Cancer Biology | Daniel Feinberg, Yorleny Vicioso, Derek Wong | Novel therapeutic approaches for cancer; activating natural killer cells for adoptive therapy of pediatric cancers; developing therapeutic tools combining immunology with glycobiology; exploiting the cancer cell-specific immune receptors and glycan expression patterns | |
| Stanton Gerson, MD | Molecular Virology, Pharmacology, Biochemistry | Kevin Allan | Transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells |
Medicine (Infectious Diseases)
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Robert Bonomo, MD | Pharmacology, Molecular Biology & Microbiology, Pathology/ Immunology, Biochemistry | Rupleen Kaur, Emma Kundracik, Nicholas Venetos | Structure-function studies of beta-lactamases; enzymological factors that permit evolution of beta-lactamases in the clinic; development of immunological tools to study beta-lactamase expression in enteric bacilli; application of molecular diagnostics to the rapid diagnosis of infectious diseases; testing and development of novel beta-lactams and beta-lactamase inhibitors | |
| W. Henry Boom, MD | Pathology/ Immunology, Molecular Biology & Microbiology | T cell biology, tuberculosis, immune evasion, pulmonary host defense, antigen processing, anti-microbial immunity, basic and translational TB research | ||
| David Canaday, MD | Pathology/ Immunology | Olubukola Abiona | Immunology of infectious diseases; study of HIV-TB interaction; cellular interactions resulting in loss of control of M. tuberculosis; understanding immune defects that develop with aging | |
| Atul Chopra, MD, PhD | Genetics and Genome Sciences | Brendan Boylan | Bijoya Basu, Brian Kim | Energy homeostasis and metabolic disease |
| Carlos Subauste, MD | Pathology/ Immunology | Immunology, autophagy in host-pathogen interactions, Toxoplasma gondii, selective blockade of CD40 signaling to control inflammatory disorders (microvascular complications of diabetes, inflammatory bowel disease). |
Molecular Biology & Microbiology
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Susann Brady-Kalnay, PhD | Molecular Biology & Microbiology, Neurosciences, Pathology/ Cancer Biology, Molecular and Cellular Basis of Disease, Cell Biology | * Not currently accepting MSTP students for rotation or PhD placement | ||
| Jonathan Karn, PhD | Molecular Biology & Microbiology, Molecular Virology | Control of HIV latency in T cells and microglial cells, and efforts to cure HIV | ||
| Alan Levine, PhD* | Molecular Biology & Microbiology, Cell Biology, Molecular Virology, Pharmacology, Pathology/ Immunology | Paul Karell, Michelle Pan | Michelle Cruz, Claire Mazahery | Role of the microbiome, T lymphocytes, and epithelial cells in intestinal immunity |
| Christine O'Connor, PhD | Molecular Biology & Microbiology, Molecular Virology |
Our lab is interested in understanding the host-pathogen interactions during latency and reactivation of the cytomegalovirus (CMV), as well as the host and viral factors involved in these phases of infection, in order to CMV-induced morbidity and mortality |
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| Arne Rietsch, PhD* | Molecular Biology & Microbiology | Josephine Trichka | Emma Kundracik | Primary virulence factor of P. aeruginosa, a type III secretion system; understanding how this nanomachine works, as well as how the injected effector proteins prevent clearance of the bacterium by the patient’s immune system |
| Jacek Skowronski, MD, PhD | Molecular Biology & Microbiology, Molecular Virology | Identifying cellular co-factors of HIV/SIV-encoded proteins and selected cellular proteins that can block HIV replication |
Neurosciences
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Heather Broihier, PhD* | Neurosciences | Dan Jindal | Developmental neurobiology; Molecular mechanisms of synaptic development and plasticity | |
| Evan Deneris, PhD | Neurosciences | Xinrui Zhang | Molecular genetics of the brain serotonergic transmitter system | |
| Lin Mei, MD, PhD | Neurosciences | Mechanisms of synapse formation, neurotransmission, and synaptic plasticity
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| Pola Philippidou, PhD* | Neurosciences | Katherine Letai | Alicia Vagnozzi | Molecular mechanisms of neural circuit assembly during development, genetic control of phrenic motor neuron identity; synaptic specificity in respiratory circuits; Hox genes |
| Jerry Silver, PhD* | Neurosciences | Elliot Choi, Sydney Song | Role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, axon guidance | |
| Ben Strowbridge, PhD | Neurosciences | Synaptic Physiology, hippocampus, olfactory bulb, Computational Neuroscience | ||
| Qian Sun, PhD | Neurosciences |
Our lab studies the function of the hippocampal circuit, a brain area that is vital for memory formation and is strongly linked to many neuropsychiatric disorders, such as PTSD, depression, schizophrenia, and Alzheimer's disease. We use a variety of in vitro and in vivo techniques – including electrophysiology, neuronal tracing, optogenetics and chemogenetics, immunohistochemistry, and mouse behavior – to address the cellular and circuit mechanisms underlying hippocampal information processing and its relevance to behaviors |
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| Masashi Tabuchi, PhD | Neurosciences |
Electrical signals in neurons underlie the computations made by the brain, and these signals act at biophysical and neural circuit levels to generate behavior. The broad goal of my lab is to elucidate how internal states persist in time and identify the molecular mechanisms which shape the neural processing underlying these processes. By illuminating the cellular and synaptic basis of sleep and protein hunger, we expect to gain key insights into the principles of neural codes underlying persistent internal drive of the brain and to provide a framework to understand how these factors ultimately contribute to our health |
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| Wen-Cheng Xiong, PhD | Neurosciences | Preethy Sridharan | Molecular mechanisms underlying neural development, neuro-degeneration, and bone homeostasis | |
| Peng Zhang, PhD | Neurosciences |
Neurexins are essential for synaptic function and are among the list of high-risk genes for neuropsychiatric disorders especially autism spectrum disorder, schizophrenia, and intellectual disabilities. Using primary neuron cultures and transgenic mouse models, we aim to understand how activity of neurexins can be regulated to shape the synapse development and brain function. Hence, our research not only expands basic knowledge of synapse development, but also provides insights on synaptic pathologies seen in psychiatric diseases |
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| Richard Zigmond, PhD | Neurosciences, Pathology | Willie Miller-LIttle, Xinrui Zhang, Bowen Zhou | Aaron Talsma | Study of the plasticity in the adult nervous system. We are interested in the ways in which the chemistry of the adult nervous system can change and the functional consequences of such changes. We focus particularly on alterations that occur in response to neural damage whether produced by trauma or disease, with particular interest in neuro-immune interactions that occur in response to injury, using molecular, biochemical, immunological, histochemical, and cell culture approaches |
Nutrition
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Danny Manor, PhD | Nutrition, Pharmacology, Pathology, Cancer Biology | * Not currently accepting MSTP students for rotation or PhD placement
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Ophthalmology & Visual Sciences
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Paul Park, PhD | Pharmacology, Biochemistry | Mechanism of action of rhodopsin and other G protein-coupled receptors | ||
| Irina Pikuleva, PhD | Pharmacology | Jennings Luu | The two major areas of research in this laboratory are studies of cholesterol maintenance in the retina and brain. The ultimate goal of these studies is to delineate the importance of cholesterol-related pathways for retinal and brain functions and whether pharmacologic modulation of these pathways could lead to disease-modifying treatments for retinal and brain disorders. |
Orthopedics
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Ronald Triolo, PhD | Biomedical Engineering | Rehabilitation engineering, neural control of motion, lower-extremity neuroprostheses, orthopaedic biomechanics, and prosthetic/orthotic design |
Otolaryngology
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Brian McDermott, PhD | Genetics & Genome Sciences, Neurosciences | Kathleen Plona | Sensory Neurobiology, Hearing and Deafness, Zebrafish Genetics, Mechanotransduction, Synapse development, Translational Neuroscience | |
| Qing Zheng, MD | Genetics & Genome Sciences | Genes, molecular pathways and drug discovery involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome |
Pathology
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Derek Abbott, MD, PhD* | Pathology/ Immunology/Cancer Biology | Michelle Cruz, Kevin Newhall, Michelle Pan, Otis Pinkard, Vanessa Salazar, Stephen Wang | Hannah Kondolf, Meghan O'Keefe, Michelle Pan, Bowen Zhou | Inflammatory diseases and innate immune signaling pathways |
| Stanley Adoro, PhD |
Pathology/ Cancer Biology/ Immunology
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Alexander Lesser | Brendan Barton, Josephine Trichka | Hematopoiesis, hematopoietic stem cells, acute myeloid leukemia, T-cell homeostasis, and autoimmunity |
| Aaron Burberry, PhD | Pathology/ Immunology, Pathology/ Molecular and Cellular Basis of Disease | Understanding mechanisms that contribute to neural inflammation in neurodegenerative diseases, building upon the discovery that signals from the gut microbiota influence the extent of neural inflammation that develops in mice with mutations in genes that cause the neurodegenerative disorder Amyotrophic lateral sclerosis (ALS). The lab focus extends to other neurodegenerative disorders including Alzheimer’s disease | ||
| Adam Burgener, PhD | Pathology | Our laboratory specializes in mass spectrometry based proteomics and systems biology to study host immunity, the microbiome, and interactions in infectious diseases. A central focus of our research has been to study host and microbial factors at mucosal surfaces that underlie of the acquisition and pathogenesis of HIV. The goal is to apply this knowledge to develop novel preventative, diagnostic, and therapeutic strategies. | ||
| Brian Cobb, PhD | Pathology/ Immunology | Paul Karell, Claire Mazahery | Antigen processing and presentation of carbohydrate antigens | |
| Wendy Goodman, PhD | Pathology/ Immunology | Receptors for steroid hormones (estrogens, androgens and progesterone) are broadly expressed and function to regulate gene transcription in target cells. Our lab studies how these pathways operate in immune cells, particularly how they contribute to the balance between immune homeostasis and chronic inflammation & autoimmunity. Particular areas of interest include mucosal tissues (i.e. intestinal mucosa) and maternal-fetal interface tissues (decidua). Our approach utilizes both preclinical mouse models and primary human cells/tissues | ||
| Clifford Harding, MD, PhD* | Pathology/ Immunology | Leo Kim, Claire Mazahery, David Sweet | * Not currently accepting MSTP students for rotation or PhD placement | |
| Stanley Huang, PhD | Pathology/Molecular and Cellular Basis of Disease | Alex Lesser | Understanding the interplay between cellular signaling and metabolic regulation that dictates immune cell activation during inflammation and cancer | |
| Mark Jackson, PhD | Pathology/ Cancer Biology | Genetic events that contribute to breast hyperplasia | ||
| David Kang, PhD | Pathology/ Molecular and Cellular Basis of Disease | Mechanisms of neurodegeneration in Alzheimer’s disease (AD) and related disorders (ADRDs) such as Frontotemporal dementia (FTD), Amyotrophic Lateral Sclerosis (ALS), and Lewy body dementia (LBD). We utilize molecular, biochemical, cell biological, advanced imaging, and animal modeling tools to answer important questions pertinent to healthy vs. pathological brain aging. | ||
| Qingzhong Kong, PhD | Pathology | Prion diseases, functions of cellular prion protein in biology and diseases, muscle stem cells, and gene therapy | ||
| Allison Kraus, PhD | Pathology/ Molecular and Cellular Basis of Disease | Hannah Zamore | Misfolded proteins and self-propagating protein seeds of neurodegenerative diseases including Alzheimer’s, chronic traumatic encephalopathy, and prion diseases | |
| Kenneth Matreyek, PhD | Pathology/ Immunology | Understanding how protein sequence variants contribute to disease, and discovering rationally engineered proteins able to fight them. Development and deployment of new multiplex genetic biotechnologies capable of assessing the impacts of protein sequence changes, focusing on genes that modulate immunity or predispose individuals to autoimmunity | ||
| M. Edward Medof, MD, PhD |
Pathology | Intrinsic cell surface regulators: the decay-accelerating factor (DAF or CD55), membrane cofactor protein (MCP or CD46), and membrane inhibitor of reactive lysis (MIRL or CD59) | ||
| Vincent Monnier, MD | Pathology/Immunology, Biochemistry | Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology | ||
| Andrew Pieper, MD, PhD* | Pathology/ Molecular and Cellular Basis of Disease, Neurosciences | Sofia Corella | Sarah Barker, Sofia Corella, Preethy Sridharan | Discovery and development of new therapeutic opportunities in neurodegeneration |
| Parameswaran Ramakrishnan, PhD | Pathology/ Immunology, Biochemistry | Brendan Barton, Willie Miller-Little | Angela Liu | Autoimmune diabetes, chronic inflammation and inflammatory bowel disease, Leukemia, O-GlcNAcylation, Cell signaling and identification of novel therapeutic targets |
| Jiri Safar, MD | Pathology | Prion, Alzheimer, and other neurodegenerative diseases caused by protein misfolding; Prion, amyloid, and tau strains; molecular basis and structural biology of neurodegeneration; translational medicine of age-related dementias | ||
| Thaddeus Stappenbeck, MD, PhD | Pathology/ Immunology | Syrena Bracey, Paul Karell, Jeehyun Karen You | Paul Karell, Kevin Newhall |
The Stappenbeck lab is interested in discovering host and environmental factors that impact inflammation and wound repair at mucosal surfaces, with the focal point often being the intestinal epithelial barrier and the microbiome. To approach these problems, combinations of studies using human cells and tissues as well as mouse and in vitro models are used. |
| Alan Tartakoff, PhD | Pathology | Kathleen Plona, Bowen Zhou | * Not currently accepting MSTP students for rotation or PhD placement | |
| David Wald, MD, PhD* | Pathology/ Cancer Biology, Pathology/ Immunology | Ryan Gimple | Identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML) and colon cancer. Preclinical and clinical studies of novel cell therapies for cancer including CAR-T cells and NK cell therapies | |
| Lily Wang, PhD | Pathology/Immunology, Biomedical Engineering | Identification of novel inhibitory receptors that regulate the differentiation and functions of tumor-reactive cytotoxic T cells and tumor-associated myeloid cells including TAMs and MDSCs. Preclinical tumor models and ex vivo cellular and molecular analyses are applied to dissect immunosuppressive signaling pathways and develop therapeutic strategies to target these pathways for cancer immunotherapy. | ||
| Alexa Woo, PhD | Pathology/ Molecular and Cellular Basis of Disease | My lab focuses on G-protein coupled receptors and beta-arrestins signaling in neurodegenerative diseases, including Alzheimer’s Disease (AD) and AD-related dementia. We also study the role of mitochondrial protein CHCHD2 in Lewy body disorders. | ||
| Pathology/Immunology, Physiology and Biophysics, Structural Biology, Pharmacology, Molecular and Cellular Basis of Disease | Henock Befekadu | Syrena Bracey | Structural and biochemical studies of important immune receptors; understanding and modulating their functions for diagnostic and therapeutic applications | |
| Lan Zhou, MD, PhD* | Pathology/ Cancer Biology | Peter Qiao, Yorleny Vicioso | Notch-dependent regulation of hematopoietic stem cell proliferation, differentiation, and niche location; leukemia microenvironment regulation; Notch signaling in solid tumor progression; fucosylated glycans in hematopoiesis and cancer biology | |
| Xiongwei Zhu, PhD | Neuroscience, Pathology | Muta Abiff, Aaron Talsma | Neurodegenerative mechanisms underlying Alzheimer disease and other neurodegenerative diseases |
Pediatrics
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Mitchell Drumm, PhD | Genetics & Genome Sciences | George Luo | Kathleen Plona | How variants in the genome influence the course of disease for CF patients and how the CF genome adapts to the disease |
| Alex Huang, MD, PhD* | Pathology/ Cancer Biology, Immunology | Ellen Hong, Derek Wong | Muta Abiff, Alicia Aguilar, Melissa Bonner | Tumor immunology; Intravital two-photon laser scanning microscopy; T cell and chemokine receptor biology; cellular trafficking, migration and interaction in inflammation, cancer and autoimmunity |
| John Letterio, MD | Biochemistry | Brendan Barton | George Luo | Discovery of the critical roles of TGF-ß in hematopoietic and immune cell function |
Pharmacology
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Scott Cameron, MD PhD | Pharmacology |
Circulating platelets start the process of forming blood clots. My laboratory discovered that platelets become reprogrammed in diseases such as heart attack and peripheral artery disease. We study novel signaling pathways in platelets that can be used as druggable targets, utilizing high throughput drug screening, contemporary pharmacology and biochemistry, molecular biology, and animal models of vascular disease to meet these goals. |
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| Chris Dealwis, PhD | Pharmacology | The main focus of my lab involves understanding the structural organization requirements by multiple protein assemblies to facilitate biological function, and to rationally design small molecule inhibitors as drugs against target molecules responsible for disease states. Our approach is to use a multidisciplinary cycle to study the structure-function relationship of proteins and drug design. Currently our lab is designing small molecule drugs against cancer and in the past we have develop therapeutic agents against Alzheimer’s disease. Biophysical tools such as x-ray; neutron crystallography, molecular modeling, CD, MS, fluorescence spectroscopy and ultracentrifugation are the techniques used in our lab. |
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| Maria Hatzoglou, PhD | Nutrition, Pharmacology, Genetics and Genome Science | Syrena Bracey, Xinrui Zhang | Arginine metabolism, gene regulation, viral receptors and gene therapy | |
| Ruth Keri, PhD | Pathology/Cancer Biology, Genetics and Genome Sciences | Syrena Bracey | Natasha Ingles, Katrina Piemonte, Bryan Webb | Hormonal control of mammary gland development and construction of transgenic mouse models of breast cancer; functional genomics of mammary gland development and cancer |
| Jason Mears, PhD | Pathology, Pharmacology | Molecular machinery associated with mitochondrial division in yeast and mammalian cells; understanding the relationship between mitochondrial dynamics and disease | ||
| Marvin Nieman, PhD | Pharmacology, Cell Biology, Systems Biology and Bioinformatics | Platelet signaling in thrombosis and cancer | ||
| Phoebe Stewart, PhD | Pharmacology | Applying cryo-EM structural methods to a variety of biological complexes including viruses, viral/host factor complexes, engineered adenovirus-based vaccines, membrane proteins and nanoparticles | ||
| Derek Taylor, PhD* | Pharmacology, Biochemistry | Raza Haider | Daniel Leonard, Otis Pinkard | Computational Biology, Macromolecular Structure Determination, Drug Design. My laboratory defines the molecular mechanisms associated with disease and develops new strategies and therapies for cancer treatment |
| Edward Yu, PhD | Pharmacology | Molecular mechanisms of bacterial efflux transporters that mediate antimicrobial resistance |
Physiology & Biophysics
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Walter Boron, MD, PhD | Biochemistry, Physiology & Biophysics | Erik Koritzinsky | Molecular, cellular, and whole-animal studies to elucidate the molecular mechanisms and translational implications of pH regulation and the transport of bicarbonate and gases (O2, CO2) | |
| Matthias Buck, PhD | Physiology & Biophysics | Molecular Biophysics of small GTPase-protein interactions in neuronal, cardiovascular, and cancer cell signaling; molecular biology, NMR and X-ray spectroscopy, and thermodynamic measurements to determine the basic mechanisms by which proteins transmit signals in cells | ||
| Sudha Chakrapani, PhD* | Physiology & Biophysics, Neurosciences | Sarah Venus | Role of structure and dynamics in the functioning of ion channels | |
| George Dubyak, PhD* | Physiology & Biophysics, Pharmacology, Pathology/ Immunology | Brian Fort, Jacob Ingber, Angela Liu, Kyle Starost | Inflammatory and apoptotic signal transduction; Signaling by receptors for extracellular ATP in innate immunity, cardiovascular disease, and cancer | |
| Xin Qi, PhD | Physiology & Biophysics | Lucie Ahn, Thomas Lavin, Nicholas Venetos | Regulation of mitochondrial dysfunction in neurodegenerative diseases; development of therapeutic approach for the treatment of diseases; cellular and molecular mechanism on mitochondrial quality control and immunometabolism; brain lipid metabolism in neurodegenerative disease | |
| Corey Smith, PhD | Physiology & Biophysics | Regulation of the sympatho-adrenal stress response | ||
| Julian Stelzer, PhD | Physiology & Biophysics | Cardiac contractility, heart failure, hypertrophic cardiomyopathy, cardiac muscle diseases, cardiac gene therapy, small molecule drug delivery, computational modeling of heart function | ||
| Witold Surewicz, PhD | Physiology & Biophysics, Pathology | Michael Babinchak, Raza Haider | Molecular basis of neurodegenerative diseases associated with protein misfolding and aggregation; The role of liquid-liquid phase separation in neurodegenerative diseases |
Population and Quantitative Health Sciences
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| William Bush, PhD | Epidemiology & Biostatistics, Systems Biology & Bioinformatics, Genetics & Genome Sciences | Genomics research on Alzheimer’s disease | ||
| Dana Crawford, PhD* | Epidemiology & Biostatistics, Genetics and Genome Sciences | Applying genetic variation data to large-scale epidemiologic and clinical cohorts to better understand human genotype-phenotype associations, with an emphasis on diverse populations | ||
| Darcy Freedman, PhD, MPH | Epidemiology & Biostatistics | Uriel Kim | Substantive Topic Areas of Interest: Food Access Interventions (e.g., farmers’ markets, community gardens, food policy); Community-engagement and Civic Participation; Public Health Literacy; Primary Prevention of Chronic Disease (e.g., Obesity, diabetes, cancer); Nutrition and Food Security | |
| Jonathan Haines, PhD | Epidemiology & Biostatistics, Genetics & Genome Sciences | Bijoya Basu, Zita Hubler, Michael McHenry | Genomic and computational approaches to understand the pathophysiology of human disease | |
| Sudha Iyengar, PhD | Epidemiology & Biostatistics, Genetics & Genome Sciences, Systems Biology & Bioinformatics, Clinical Transitional Science | Genetics of complex diseases in humans (ocular genetics/epidemiology, renal genetics, speech sound disorder/epidemiology, genetic methods) | ||
| Nora Nock, PhD | Epidemiology & Biostatistics, Systems Biology & Bioinformatics | Using various "-omics" and neuroimaging approaches to better understand the genetic, environmental, behavioral and neural determinants of obesity and cancer; innovative lifestyle interventions in overweight and obese cancer survivors | ||
| Fredrick Schumacher, PhD | Epidemiology & Biostatistics | Paulameena Shultes | Deciphering the inherited genetic architecture of complex traits, particularly cancers of the prostate, colon and breast; studies using quantitative and population sciences, particularly molecular and genetic epidemiology, to elucidate the genetic architecture of complex phenotypes | |
| Catherine Stein, PhD* | Epidemiology & Biostatistics, Systems Biology & Bioinformatics, Clinical and Translational Science | Michael McHenry | Genetic and environmental susceptibility to tuberculosis and other infectious diseases, and multivariate methods for analyzing complex diseases | |
| Daniel Tisch, PhD, MPH | Epidemiology & Biostatistics | Epidemiology of lymphatic filariasis, malaria, and schistosomiasis. Meta-analysis and mathematical modeling of parasite control strategies. Evaluation of integrated parasite control programs | ||
| Scott Williams, PhD | Epidemiology & Biostatistics, Genetics & Genome Sciences, Systems Biology and Bioinformatics, Clinical Transitional Science | Emily Hannon | Razaq Durodoye | Distribution of genetic variation among human populations and the role that differences in patterns of variation play in disparity of disease among populations; diversity among African and African descent populations; multiple diseases that are either more common in these populations, such as hypertension and preterm birth, or less common, such as gastric cancer |
| Xiaofeng Zhu, PhD | Epidemiology & Biostatistics | Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping; bioinformatics |
Radiology
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Agata A Exner, PhD* | Biomedical Engineering, Pathology/ Cancer Biology | Natalie Hong | Michaela Cooley | Minimally invasive methods of cancer treatment including: ultrasound-modulated, image-guided drug delivery, thermosensitizers for focused hyperthermia, and vasomodulation for improved local ablation and treatment follow-up |
| Christopher Flask, PhD | Biomedical Engineering | Quantitative MRI Assessments of Cystic Fibrosis, Diabetic Nephropathy, Sickle Cell Disease, Pyelonephritis, Polycystic Kidney Disease, and Non-Alcoholic fatty Liver Disease |
Rammelkamp Center for Research, MetroHealth Hospital
| Mentor | PhD Programs | MSTP Student Rotations | Current MSTP PhD Students | Research Description |
|---|---|---|---|---|
| Bing-Cheng Wang, PhD | Pathology/ Cancer Biology, Pharmacology, Physiology & Biophysics | Molecular mechanisms of tumor initiation and maligant progression of prostate cancer and brain tumor, Tumor immunotherapy, Structure-function relationship of receptort tyrosine kianses, Development of small molecule therapeutics for metastatic cancer |