Themed Pilots

Contacts

Pilot questions should be directed to:

Anna Thornton Matos, MPH

 

2026 Pilot Funding Opportunity to Address the Health Concerns & Conditions of Rural Ohio

 

Title:  Timely access to innovations in health outcomes for Rural Ohio
Available Funds: Up to 4 pilot awards at $25,000 to $50,000 each
Funding Period: April 1, 2026 - March 31, 2027
Application Deadline: Monday, December 1, 2025 at 11:59PM EST
Funding Source: Clinical and Translational Science Collaborative of Northern Ohio at Case Western Reserve University

2026 CTSC Themed Pilot full RFA [PDF]

The Clinical and Translational Science Collaborative (CTSC) of Northern Ohio at Case Western
Reserve University (CWRU) requests applications for pilot research funding to enhance and grow CTSC activities in the area of rural health.

The CTSC seeks applications from faculty at Case Western Reserve University, Cleveland Clinic, MetroHealth Medical Center, University Hospitals Cleveland Medical Center, the VA Northeast Ohio Healthcare System, Northeast Ohio Medical University (NEOMED), and the University of Toledo.

We intend to award up to four pilot grants, with award amounts at $25,000 to $50,000 each. As with all CTSC activities, and to enhance collaborations among partners, proposed studies must include at least two different CTSC institutions. 


There are particular health conditions prevalent in the rural Midwest in general, and Ohio in particular, that mirror chronic health conditions in rural areas across the nation. Rural populations suffer disproportionately from chronic diseases like heart disease, hypertension, type 2 diabetes, COPD, and others. Access to health care affects timely attention to other health conditions, like cancer, mental illness, and neurological disorders. Early diagnosis and remediation/monitoring of all diseases improve outcomes and lower healthcare utilization. Travel time, access to clinical specialization, including diagnostic equipment and facilities, and pharmacy support are examples of challenges faced by rural populations. Northern Ohio provides a representative environment for expanding research engagement and reproducing the effectiveness of health interventions across various settings applicable to all Americans. 

This themed pilot invites projects addressing the health concerns and conditions of rural Ohio. These goals are in concert with the NIH and NCATS Clinical and Translational Science Awards (CTSA) Program. All are committed to accelerating clinical and translational research to address the significant burden of conditions that affect rural populations.

There are four areas of interest in this Pilot Funding Opportunity:

  1. Address challenges to participation in clinical research and broader engagement in clinical trials.
  2. Enhance urban-rural collaborative efforts by strengthening coordination between urban institutional partners and rural community collaborators.
  3. Develop and implement Point-of-Care and mobile technologies that extend the reach and effectiveness of health interventions across a variety of clinical settings.
  4. Address the drivers of chronic disease through preventative and therapeutic lifestyle interventions.

Areas of particular interest:

  • innovative use of Artificial Intelligence (AI),
  • demonstrate attention to dissemination and implementation,
  • mobile technologies,
  • decentralized trial with remote monitoring.

Increasing the speed, efficiency, and effectiveness of clinical and translational research will reduce disease burden and address health disparities in rural areas. Persistent variation in key health indicators, such as life expectancy, chronic disease rates, and access to care, reflects the need for more consistent integration of research into practice. Inconsistencies in recruitment and enrollment across clinical studies may limit the broader applicability and operational impact of research findings.

Case Western Reserve University will serve as the fiscal entity through which each award will be distributed and administered. Awardees will receive additional information regarding disbursement workflow.

Important Considerations and Requirements:

  1. Applicants must have an Rural Health-themed pilot consultation with CTSC Pilot Module staff/faculty as they prepare their applications. Visit https://sparc.case.edu/ > Grant Development > Grant Writing Consultation OR https://sparc.case.edu > Funding Opportunities > Themed Pilot

SECTION I: GENERAL REQUIREMENTS (applies to all applications)

Applicants must read and follow all application instructions in this section as well as funding-specific
instructions noted in Section II.

  • Principal Investigators (PIs) must have a PhD, MD, JD, PharmD, PsyD, DNP or equivalent doctoral-level degree and have a faculty appointment at CWRU or one of the CTSC partner institutions, including: University Hospitals, Cleveland Clinic, VA Northeast Ohio Health System, MetroHealth, Northeast Ohio Medical University or the University of Toledo.
  • Co-PIs are permitted, but each applicant must submit only one application as PI or co-PI.
  • Interested prospective applicants who do not have doctoral-level degrees (e.g., non-clinical staff with master’s degrees, undergraduate degrees, high school diplomas or the equivalent) are highly encouraged to apply by collaborating with a PI.
  • The institution of record will be the PI’s primary institution. If the application has two co-PIs, one should be designated as the contact PI and their institution will act as the primary institution of record.
  • PI, co-PI(s), and study team members should involve interdisciplinary institutional departments, as appropriate, in the development of their pilot proposal.
  • IRB - Studies involving human subjects must have IRB approval by March 1, 2026 before funds will be released and will not change the expectation for significant progress to be made within three-to-six months. The likelihood of gaining IRB approval promptly will be considered as part of the feasibility criteria.

Budget Considerations: 

  • PI, co-PI(s), and/or study team staff salaries are permitted, including paying community consultants for the execution of the project.
  • Indirect costs are not permitted.
  • Allowable costs: recruitment materials; rental of UH Mobile Research Unit; study supplies; community member consultant fees; consumable equipment and/or technology with justification for use in the project; space rental fee; food for events specifically outlined in the application.
  • Unallowable costs: tuition, travel, publication costs, conferences, equipment that is not consumed by the project.
  • All award funding must be spent by March 31, 2027. No-cost extensions (i.e., the project end date will not be extended, nor will the funder add additional funds to cover the extension) will not be granted.

APPLICATION PROCESS

Application must be submitted electronically no later than Monday, December 1, 2025 at 11:59PM via InfoReady.
  1. Schedule and complete the Rural Health-themed pilot consultation with CTSC Pilot Module Staff as they prepare their applications.
  2. SPARC is the CTSC's service request system and will issue a Project ID number for the consultation. 
  3. After scheduling your consultation, the Project ID number issued to your project will also be the ID number used when applying for the Rural Health-themed pilot in the InfoReady system (CWRU Grants management platform)
  4. Navigate to InfoReady to submit your application: https://cwru.infoready4.com 

PREPARING YOUR SUBMISSION

The InfoReady System will require the following information or documents to be provided or uploaded.

Formatting

  • Please review the online submission form before preparing your final documents.
  • All uploaded documents must be PDFs.
  • Please use size 11 pt. Arial font with 0.5” margins.
  • Maintain margins and adequate spacing between paragraphs and note maximum length for each document.

Information and Documents

  • A short summary of the work directed to the general public (i.e., plain language summary) (500 characters, including spaces)
  • Specific aims (maximum one page, uploaded as a PDF)
  • Significance and urgency, specifically addressing how this project will advance health outcomes through integrative medicine approaches (maximum one-half page, uploaded as PDF)
  • Research Strategy (maximum two pages, uploaded as PDF) that includes:
    • Study design, hypothesis, expected results.
    • Study population
    • Approach (methods, data collection, measures, analyses)
    • Investigative team
    • Feasibility
    • Dissemination and implementation plan and next steps (i.e., extramural funding)
  • References or URLs (maximum 10 references uploaded as part of the Research Strategy PDF)
  • Study timeline and deliverables (applicants must show significant progress within three-to-four months), including plan and timeline for dissemination of research findings and for seeking extramural funding (maximum one-half page, uploaded as PDF)
  • Figures may be included as appendices (maximum two pages total for appendices)
  • If human/animal subjects are involved, approved Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC) or copy of IRB/IACUC application must be included with the application as an uploaded PDF.
  • Detailed budget (please download and complete the NIH budget form found on the InfoReady Integrative Medicine Pilot Funding Opportunity)
    • Note: The fringe rate for staff salaries (if applicable) is the current non-federal rate of 34%.
    • Note: There are no Indirect Costs associated with this award.
  • Budget justification (provide description and rationale for each expense listed in budget)
  • NIH-format biosketches for personnel (maximum five pages per biosketch uploaded as a single PDF)
  • Letter(s) of support/commitment (as applicable) (maximum five pages, maximum one page per letter uploaded as a single PDF)

REVIEW PROCESS

  • Proposals will be reviewed by a scientific review committee (committee) comprised of reviewers from each institutional partner hospital, may include representatives from: information technology, innovation, community health or community outreach and engagement, and the community at-large. CTSC staff will provide administrative oversight throughout the review process to ensure a standardized review process.
  • Reviews will be conducted using NIH-style scoring methods: (1) significance, (2) investigators, (3) approach, (4) feasibility, and (5) overall impact.
  • The committee will take the following into consideration:
    • Clear articulation of the problem being addressed in the proposed project,
    • Demonstration of how the proposed work may directly contribute to developing new knowledge toward improved health outcomes through integrative medicine approaches for diverse, historically excluded, and under-resourced populations,
    • Significance, innovation, and timeliness,
    • Expertise of the investigative team and evidence of commitment of investigators and stakeholders to collaborate,
    • Feasibility,
    • Evidence of tangible deliverables, a timeline, dissemination, and implementation plans, and plans for future funding,
    • Likelihood of future success,
    • Budget and budget justification,
    • Dissemination of research findings at a CTSC Forum.