Systolic Blood Pressure Intervention Trial (SPRINT)
SPRINT was a research study funded by the National Institutes of Health to answer the following question:
"Will lower blood pressure reduce the risk of heart and kidney diseases, stroke, or age-related declines in memory and thinking?"
More than 9,000 participants were enrolled into the study at more than 90 clinics across the United States and in Puerto Rico. SPRINT participants were seen regularly by experts in blood pressure management for a period of 4 to 8 years. At the end of the trial, the results of SPRINT answered the proposed question: If a lower recommended blood pressure might help to decrease stroke, heart disease, progression of chronic kidney disease, and age-related losses of memory and thinking.
Selected Publications
Wright Jr., J. T., Whelton, P. K., Johnson, K. C., Snyder, J. K., Reboussin, D. M., Cushman, W. C., Williamson, J. C., Pajewski, N. M., Cheung, A. K., Lewis, C. E., Oparil, S., Rocco, M. V., Beddhu, S., Fine, L. J., Cutler, J. A., Ambrosius, W. T., Rahman, M. Still, C. H., Chen, Z., Tatsuoka, C. for the SPRINT Research Group. (In press). SPRINT Revisited. Updated Results and Implications. Hypertension (Dallas, Tex.:1979), 78(6), 1701–1710. https://doi.org/10.1161/HYPERTENSIONAHA.121.17682.*
Glasser, S. P., Vitolins, M., Rocco, M. V., Still, C. H., Cofield, S. S., Haley, W. E., Goff, D., & SPRINT Research Group (2021). Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT). American Journal of Hypertension, hpab145. Advance online publication. https://doi.org/10.1093/ajh/hpab145.*
Still, C. H., Rodriguez, C. J., Wright, J. T., Jr, Craven, T. E., Bress, A. P., Chertow, G. M., Whelton, P. K., Whittle, J. C., Freedman, B. I., Johnson, K. C., Foy, C. G., He, J., Kostis, J. B., Lash, J. P., Pedley, C. F., Pisoni, R., Powell, J. R., Wall, B. M., & SPRINT Writing Group For the SPRINT Research Group. (2017). Clinical outcomes by Race and Ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT). American Journal of Hypertension, 31(1), 97-107.
Rodriguez, C. J., Still, C. H., Garcia, K. R., Wagenknecht, L., White, S., Bates, J. T., Del Cid, M. V., Lioudis, M., Lopez Barrera, N., Moreyra, A., Punzi, H., Ringer, R. J., Cushman, W. C., Contreras, G., Servilla, K., Rocco, M., For the SPRINT Research Group. (2017). Baseline blood pressure control in Hispanics: Characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial. (2017). Journal of Clinical Hypertension (Greenwich), 19(2), 116-125.
Pajewski, N. M., Williamson, J. D., Applegate, W. B., Berlowitz, D. R., Bolin, L. P., Chertow, G. M., Krousel-Wood, M. A., Lopez-Barrera, N., Powell, J. R., Roumie, C. L., Still, C. H., Sink, K. M., Tang, R., Wright, C. B., Supiano, M. A., for the SPRINT Study Research Group. (2016). Characterizing frailty status in the Systolic Blood Pressure Intervention Trial. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences, 71(5), 649-655.
Ramsey, T. M., Snyder, J. K., Lovato, L . C., Roumie, C. L., Glasser, S. P., Cosgrove, N. M., Olney, C. M., Tang, R. H., Johnson, K. C., Still, C. H., Gren, L. H., Childs, J. C., Crago, O. L., Summerson, J. H., Walsh, S. M., Perdue, L. H., Bankowski, D. M., Goff, D. C, for the SPRINT Study Research Group. (2016). Recruitment strategies and challenges in a large intervention trial: Systolic Blood Pressure Intervention Trial. Clinical Trials, 13(3), 319-330.⃰
Still, C. H., Craven, T. E., Freedman, B. I., Van Buren, P. N., Sink, K. M., Killeen, A. A., Bates, J. T., Bee, A., Contreras, G., Oparil, S., Pedley, C. M., Wall, B. M., White, S., Woods, D. M., Rodriguez, C. J., Wright, J. T., Jr, & SPRINT Study Research Group (2016). Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial. Journal of the American Society of Hypertension, 9(9), 670-679.*