HIV Biobehavioral and Symptom Science

Hands holding red HIV awareness ribbon in front of a sunset.

The HIV Biobehavioral and Symptom Science Lab is dedicated to conducting and cultivating multidisciplinary basic, translational and clinical research to help adults with HIV live and age well. We use innovative and rigorous research techniques to examine how non-pharmacological approaches prevent and mitigate chronic disease, reduce symptoms, and improve quality of life in people living with HIV.

Current Studies

Healthy foods, a scale, weights and a stethoscope laid out on a blue background.

The PROSPER-HIV Study is a 5-year observational study investigating how physical activity and diet intake impact the symptom experience of adults living with HIV. This study is being conducted at University Hospitals, Cleveland Medical Center; University of Alabama at Birmingham; University of Washington; and Fenway Health.

Alarm clock in foreground and a man waking up and stretching in bed in the background.
Sleep K23

The Sleep K23 Study is a 3-year study comparing the effectiveness of high-intensity interval training (HIIT) and continuous moderate-intensity exercise (CME) interventions on sleep in older people with HIV.

Woman wearing a face mask and holding a red HIV awareness ribbon with her arms raised triumphantly.
Study 8

Case Western Reserve University is serving as a site for the International Nursing Network for HIV Research, which is conducting an international study describing the impact of the COVID-19 pandemic on people living with HIV.

Person wearing blue scrubs and stethoscope holding a red heart.

EXTRA-CVD is an implementation science study adapting and testing a nurse-led intervention to reduce systolic BP in non-HDL cholesterol over 12 months in adults living with HIV. This study is being conducted at University Hospitals, Cleveland Medical Center; MetroHealth Systems; and Duke Health.

Archived Studies

The BOBCAT Study is a randomized clinical trial testing the effect of an innovative self-management intervention to improve exercise, diet and cardiovascular health in adults living with HIV.

Learn more about the BOBCAT Study.

Understanding the Management of Chronic Disease in Women Living with HIV/AIDS (MANAGE)

The MANAGE study examined self-management as practiced by women living with HIV/AIDS in the context of their lives and developed and validated a self-reported HIV self-management scale.

Learn more about the MANAGE Study.

Exploring relationship among sTRess, Isolation, and Physical activity (TRIP) in older adults living with HIV/AIDS

This exploratory study identified modifiable psychosocial risk factors in older PLWH and laid the foundation for the development of novel, evidence-based self-management interventions for this population.

Learn more about the TRIP study.