The Case Western Reserve University Periodontics Department is dedicated to advancing periodontology through groundbreaking research and clinical trials. Our team, including esteemed faculty and ambitious residents, explores innovative treatments and technologies to improve patient care. This section highlights our current projects and past achievements, showcasing our impact on periodontal health and our commitment to excellence. Discover how our research is shaping the future of periodontics at Case Western Reserve University.

Current ongoing clinical trials:

Comparison of Surgical Techniques to Treat Isolated Gingival Recession in Mandibular Incisors: A Randomized Clinical Trial
Gian Pietro Schincaglia, DDS,PhD - Clara Sous, BDS
The primary objective of this randomized clinical trial is to compare the mean root coverage achieved with Coronally Advanced Flap (CAF) + Connective Tissue Graft (CTG) (control) to Gingival Pedicle Split Thickness flap (GPST) + CTG (test) for the treatment of isolated gingival recession defects in mandibular incisors. The secondary objectives are to compare the percentage of complete root coverage and keratinized tissue gain between the two techniques. ID NCT06037161

Immediate Versus Delayed Loading of Maxillary Overdenture Implants
Gian Pietro Schincaglia, DDS,PhD - Elysha Pomerantz, DMD
The purpose of the study is to evaluate the radiographic, clinical and patient-centered outcomes of implant-retained immediately-loaded maxillary complete dentures in comparison to delayed loading approach by primarily evaluating radiographic bone loss of dental implants placed in the maxilla over 36 months ID NCT06038487

Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Gian Pietro Schincaglia, DDS,PhD - Elysha Pomerantz, DMD
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies. ID NCT06149585

Published Research:
*Please note this is a sample list of articles.

Agusto M, Salman A, Parker D, Choi D, Schincaglia GP. Root Coverage
Predictability in the Treatment of Gingival Recessions on Mandibular Anterior
JDR Clin Trans Res. 2022 Jul;7(3):224-233. 

Schincaglia GP, Hebert E, Farina R, Simonelli A, Trombelli L. Single versus
double flap approach in periodontal regenerative treatment.
J Clin Periodontol.
2015 Jun;42(6):557-66. doi: 10.1111/jcpe.12409. Epub 2015 May 29. PMID:

Schincaglia GP, Agusto M, Thacker S, Thomas Simpson K, Salman A. Gingival
pedicle with split-thickness tunnel technique: A retrospective case series for
single mandibular anterior recessions.
Clin Adv Periodontics. 2023
Sep;13(3):137-143. doi: 10.1002/cap.10197. Epub 2022 Jun 7. 

Schincaglia GP, Hong BY, Rosania A, Barasz J, Thompson A, Sobue T, Panagakos
F, Burleson JA, Dongari-Bagtzoglou A, Diaz PI. Clinical, Immune, and Microbiome
Traits of Gingivitis and Peri-implant Mucositis.
J Dent Res. 2017
Jan;96(1):47-55. doi: 10.1177/0022034516668847. Epub 2016 Oct 8. 

Agusto M, Kordusky B, Bryington MS, Salman A, Schincaglia GP. Immediate
Loading of Four Guided Unsplinted Narrow Implants Supporting a Maxillary
Overdenture: A Minimally Invasive Approach.
Clin Adv Periodontics. 2022
Jun;12(2):118-123. doi: 10.1002/cap.10147. Epub 2021 Feb 25. 

Chapokas AR, Almas K, Schincaglia GP. The impacted maxillary canine: a
proposed classification for surgical exposure.
Oral Surg Oral Med Oral Pathol
Oral Radiol. 2012 Feb;113(2):222-8. doi: 10.1016/j.tripleo.2011.02.025.

Combinations of chronic conditions, functional limitations and geriatric syndromes associated with periodontal disease.
Alqahtani HM, Koroukian SM, Stange K, Bissada NF, Schiltz NK.
Fam Med Community Health. 2022 Aug;10(3):e001733. doi: 10.1136/fmch-2022-001733.
PMID: 35998996

Investigating the Influence of Periodontal Disease on the Association Between Complex Multimorbidity and Health: A Cross-Sectional Study.
Alqahtani HM, Koroukian SM, Stange KC, Schiltz NK, Bissada NF.
J Int Soc Prev Community Dent. 2023 Jun 29;13(3):247-257. doi:10.4103/jispcd.JISPCD_11_23. 
PMID: 37564165 

Identifying Factors Associated with Periodontal Disease Using Machine Learning.
Alqahtani HM, Koroukian SM, Stange K, Schiltz NK, Bissada NF.
J Int Soc Prev Community Dent. 2022 Dec 30;12(6):612-622. Doi: 10.4103/jispcd.JISPCD_188_22. 
PMID: 36777017 

Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV.
Mahalingam SS, Jayaraman S, Bhaskaran N, Schneider E, Faddoul F, Paes da Silva A, Lederman MM, Asaad R, Adkins-Travis K, Shriver LP, Pandiyan P.
Nat Commun. 2023 Jan 25;14(1):399. doi: 10.1038/s41467-023-36163-2.
PMID: 36693889 

The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders.
Lam GA, Albarrak H, McColl CJ, Pizarro A, Sanaka H, Gomez-Nguyen A, Cominelli F, Paes Batista da Silva A.
Inflamm Bowel Dis. 2023 Jul 5;29(7):1153-1164. doi: 10.1093/ibd/izac241.
PMID: 36527679 

Status of North American Graduate Programs in Periodontics Providing Laser Education and Clinical Training: A Cross-Sectional Survey.
Paes Batista da SIlva A, Irfan UM, Furman E, Jasinevicius TR.
Dent J (Basel). 2022 Jul 1;10(7):119. doi: 10.3390/dj10070119.
PMID: 35877393

Laser Treatment of Peri-Implantitis: A Systematic Review of Radiographic Outcomes.
Ting M, Alluri LSC, Sulewski JG, Suzuki JB, Paes Batista da Silva A.
Dent J (Basel). 2022 Jan 28;10(2):20. doi: 10.3390/dj10020020.
PMID: 35200245 

Presence of Specific Periodontal Pathogens in Prostate Gland Diagnosed With Chronic Inflammation and Adenocarcinoma.
Alluri LSC, Paes Batista da Silva A, Verma S, Fu P, Shen DL, MacLennan G, Gupta S, Bissada 
Cureus. 2021 Sep 5;13(9):e17742. doi: 10.7759/cureus.17742. eCollection 2021 Sep.
PMID: 34659955

Estimation and Correlation of Serum Albumin and Serum Alkaline Phosphatase Levels Between Smokers and Non-smokers With Generalized Chronic Periodontitis.
Lalkota H, Alluri LSC, Da Silva APB, Gummalla S, Kondareddy KMR.
Cureus. 2021 Aug 26;13(8):e17474. doi: 10.7759/cureus.17474. eCollection 2021 Aug.
PMID: 34603867 

Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection.
Bhaskaran N, Schneider E, Faddoul F, Paes da Silva A, Asaad R, Talla A, Greenspan N, Levine AD, McDonald D, Karn J, Lederman MM, Pandiyan P.
Nat Commun. 2021 Aug 26;12(1):5143. doi: 10.1038/s41467-021-25340-w.
PMID: 34446704 

Periodontal Manifestation of Type Ib Glycogen Storage Disease: A Rare Case Report.
Dababneh R, Shawabkeh A, Gharaibeh S, Khouri ZA, Amayreh W, Bissada NF.
Clin Adv Periodontics. 2020 Sep;10(3):150-154. doi: 10.1002/cap.10112. Epub 2020 Jul 28.
PMID: 33460318

Therapeutic potential of adipose tissue stem cells for periodontal regeneration.
Behdin S, Alqahtani HM, Bissada NF.
J Periodontol. 2020 Jun;91(6):732-733. doi: 10.1002/JPER.19-0340. Epub 2019 Oct 24.
PMID: 31595510 

Association between oral pathogens and prostate cancer: building the relationship.
da Silva APB, Alluri LSC, Bissada NF, Gupta S.
Am J Clin Exp Urol. 2019 Feb 18;7(1):1-10. eCollection 2019.
PMID: 30906801 

Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations.
Cortellini P, Bissada NF.
J Periodontol. 2018 Jun;89 Suppl 1:S204-S213. doi: 10.1002/JPER.16-0671.
PMID: 29926948 

The Association between Inflammatory Bowel Disease and Periodontal Conditions: Is There a Common Bacterial Etiology?
Ozmeric N, Bissada N, da Silva APB.
J Int Acad Periodontol. 2018 Apr 1;20(2):40-51.
PMID: 31522142