Program Details

Education and Training Team

Raed Dweik, MD, KL2 Program Director 
Beth Spyke, MPA, Research Education & KL2 Training Program Manager

Clifford Harding, MD, TL1 Program Director
Kathy Schultz, TL1 Training Program Administrative Director 

The CTSC KL2 is committed to producing excellent independent clinical investigators capable of leading multidisciplinary team-based research. CTSC KL2 Scholars come from diverse professional disciplines, and will be trained to conduct team-based, multidisciplinary, patient-oriented clinical research. We expect that these clinical investigators will become leaders in a re-engineered clinical research workforce.

Eligibility

Applicants must have a terminal medical degree (e.g. MD, DDS, Pharm D) or a Ph.D. or Psy.D., etc. Individuals from a variety of disciplines, for example biostatisticians, epidemiologists, behavioral scientists and nurses with doctoral degrees, are encouraged to apply. All applicants must have evidence of strong academic achievement and scholarship, as well as personal attributes such as high motivation and leadership potential. Further, applicants must be US citizens, non-citizen nationals, or lawfully admitted for permanent residence; and able to commit 75% of full-time professional effort to this Career Development Program and its related research activities.

The award is intended for individuals at a relatively early stage of training (e.g. just after the PhD degree, during, or immediately following a clinical fellowship, or within the first year or two of an initial faculty appointment). The award is intended to stimulate development of multidisciplinary research, therefore competitive applications must explain how the applicant's research development will benefit from a multidisciplinary approach.

Per NIH rules, KL2 scholars may not simultaneously submit or have pending an application for any other PHS mentored career development award (e.g., K07, K08, K22, K23), that duplicates any of the provisions of the KL2 program. Former or current principal investigators on any NIH research project grant (this does not include NIH Small Grants (R03) or Exploratory/ Developmental (R21) grants or their equivalents) or equivalent non-PHS peer reviewed research grants that are over $100,000 direct costs per year, or project leaders on sub-projects of program project (P01) or center grants (P50) are NOT eligible to participate as KL2 scholars.

Qualified Candidates

  • Hold an M.D., Ph.D., D.D.S., Pharm.D., Psy.D. or an equivalent doctoral degree
  • Have demonstrated a keen interest in clinical research
  • Must have a desire and commitment to learn how to work with scientists from different disciplines
  • Must incorporate multiple perspectives into research plan and methods that reflect an alternative to  their own training
  • Need to hold a position in one of the CTSC partner Institutions on or before May 1, 2020
  • Are U.S. citizens or have permanent resident status
  • Applications are encouraged from physicians, nurses, dentists, social and behavioral scientists, engineers, biostatisticians, epidemiologists, bioethicists and other professionals with expertise relevant to clinical research.

Benefits

Successful applicants will receive salary and benefits commensurate with prior experience and qualifications, research stipend, tuition benefits, and access to a multidisciplinary pool of highly qualified mentors who will guide their research projects and career development.

Curriculum

The KL2 is a training program with a focus on multidisciplinary and team-based clinical research.  Scholars will participate in both didactic course work and mentored research experiences over a four year period. Because of the unique backgrounds of program participants, each Scholar – in conjunction with their mentors and program leadership – will develop individualized plans of study. Scholars may elect to enroll in a Master’s degree program in Clinical Investigation, which is part of the CWRU Clinical Research Scholars Program (CRSP), or pursue other Master's degrees, or simply enroll in the required courses only as a non-degree student.

Typical Course Schedule

All Scholars will take or demonstrate proficiency in the sequence of three introductory courses:

  1. CRSP 401 Introduction to Clinical Research
  2. PQHS 490 Epidemiology: Introduction to Theory and Methods
  3. CRSP 431 Statistical Methods I

All Scholars will participate in the year-long Scholar Seminar Series (non-credit). Additionally, all Scholars will take courses designed specifically for the KL2 Program. They include:

  1. CRSP 412/413 Communication in Clinical Research (2 semesters)
  2. CRSP 501 Team Science - Working in Interdisciplinary Research Teams
  3. CRSP 502 Leadership Skills for Clinical Research Teams
  4. CRSP 503 Innovation and Entrepreneurship
  5. CRSP 603 Research Ethics: Emerging Issues and Ongoing Challenges

For those Scholars who place out of the introductory courses, more advanced courses can be substituted based on individual needs. Courses may be taken anywhere in the University and tuition will be covered by the KL2 Program.

All courses must be taken for a grade and not audited.

Summer Fall Spring
  Curriculum - Year 1  
  RESEARCH RESEARCH
CRSP 401 Introduction to Clinical Research (3)

PQHS 490 Epidemiology: Introduction to Theory and Methods (3)
CRSP 413* Communication in Clinical Research (1)
CRSP 431 Statistical Methods I (3)
CRSP 501 Team Science - Working in Interdisciplinary Research Teams (1)

Scholar Seminar (0)

CRSP 412* Communication in Clinical Research (1)

Scholar Seminar (0)

  Curriculum - Year 2  
RESEARCH RESEARCH RESEARCH
 

CRSP 603* Research Ethics: Emerging Issues and Ongoing Challenges (2)

Scholar Seminar (0)

CRSP 502 Leadership Skills for Clinical Research Teams (2)

Scholar Seminar (0)

Summer after Year 2    
CRSP 503 Innovation and Entrepreneurship (1)   *may also be taken later in the program

Program Administration

The day-to-day operation of the program, as well as planning and monitoring, is handled by the Program’s Administration.

Executive Committee

The Executive Committee is composed of Dr. Raed Dweik, Director, and three Associate Directors: Drs. Cliff Harding, Jim Spilsbury and Shirley Moore. This group will provide direct program management. These faculty and others will constitute a Steering Committee responsible for program governance. Program leadership is drawn from all participating institutions; all program leaders and mentors have faculty appointments at CWRU SOM, SON or SOE.

  • KL2 Director: Raed Dweik, MD (CCF, CCLCM of CWRU). He is currently Professor of Medicine at The Cleveland Clinic Lerner College of Medicine of CWRU, Interim Chair of the Respiratory Institute, and Director of the Pulmonary Vascular Program in the Department of Pulmonary, Allergy, and Critical Care Medicine within the Respiratory Institute at the Cleveland Clinic. He is also a staff scientist in the Department of Inflammation & Immunity in the Lerner Research Institute. He maintains an active practice in Pulmonary and Critical Care Medicine with special interest in Pulmonary Hypertension (PH) and runs an independent research laboratory with continuous NIH funding since 2002. 
  • KL2 Associate Director: Clifford V. Harding, MD, PhD (CWRU SOM/UHCMC) is the Joseph R. Kahn Professor and Chair of Pathology at CWRU and UHCMC. He has a long-standing productive NIH-funded research program on the regulation of immune responses during infection with Mycobacterium tuberculosis (Mtb) or HIV. He has been a leader in developing research training for PhD students, MD-PhD students and physician-scientists. He has been the Director of the MSTP at CWRU since 2001.
  • KL2 Associate Director: James Spilsbury, MPH, PhD (CWRU SOM) is Assistant Professor of Epidemiology & Biostatistics. He is Co-Director of the PhD program in Clinical Translational Science; Chair of the KL2 Curriculum Committee; and Director of the CTSC Academic Development Core, where he manages interdisciplinary educational and training activities. He directs Clinical Research Scholar's Program (an MS program) and a graduate certificate program in clinical research. He is a graduate of our KL2 program. Dr. Spilsbury is an anthropologist focused on the effects of social and cultural environment on children's health and well-being.
  • KL2 Associate Director: Shirley Moore, PhD, RN, FAAN (CWRU SON) is Professor and Associate Dean for Research in the SON. She is a behavioral scientist and PI of a P30 Center of Excellence in Self-Management Research. She has served as PI of several NIH-funded studies, and is experienced in building multidisciplinary teams of physicians, nurses, biomedical engineers, social workers, exercise physiologists, nutritionists, computer scientists, economists & statisticians.
  • The KL2 Steering Committee will make decisions regarding program policies; curriculum development; program guidelines; scholar selection/admissions; approval of mentors; tracking, evaluation and guidance of current scholars; and other issues facing the KL2 program. Steering Committee members will also individually provide scholar advising. The committee will track scholar performance, intervene to help when indicated, and make disciplinary decisions when needed, including dismissal from the program. The KL2 Director will be Chair of the Steering Committee which will meet at least monthly. He will also serve on all three subcommittees that will manage specific areas.

Program Mentors 

Each Scholar will be guided by two mentors: a Research Mentor and a Career Mentor. The Research Mentor will be responsible for research supervision and research career development. He or she is expected to meet with the CR Scholar on a weekly basis throughout the training program. The Research Mentor must be an active independent clinical investigator and have a successful track record of mentoring clinical investigators. The Career Mentor will be from a different clinical research discipline from the Research Mentor. The Career Mentor will support the Scholar’s academic planning, assist in understanding and managing participation in the overall program, provide a multidisciplinary perspective on the Scholar’s career development plan, and help the scholar develop multidisciplinary research. Both Research and Career Mentors will participate in the local and national evaluation activities.

KL2 Mentor Roster