Logo for the PROSPER-HIV study by the Webel Reasearch Lab.

Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of People Living with HIV (PROSPER-HIV)

Years: 2018-2023


People living with HIV (PLHIV) experience a disproportionately high symptom burden (e.g. fatigue, insomnia, pain) with few treatment options. Non-pharmacological treatment options are highly desirable for symptom management among PLHIV who already experience high pill burden from multiple comorbid diseases. Building on our previous work, the PROSPER-HIV study will examine the effect of physical activity and dietary intake as effective symptom management strategies in 850 PLHIV.

Specifically, we will:

  • Identify and characterize longitudinal, objectively-measured, physical activity and dietary patterns among PLHIV;
  • Determine which aspects of physical activity patterns and diet quality are associated with decreased symptom burden and intensity in PLHIV, and if this relationship is moderated by age and sex; and
  • Explore the potential mediating effect of anthropormorphic and physical and physical fitness variables on the relationships between physical activity, dietary patterns, and symptom burden and intensity in PLHIV.

Research Design

We will conduct a four-year, prospective, observational study of 850 Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) participants who will complete an enhanced PRO assessment to measure physical activity and diet, once a year for three years. We will integrate these measures in an enhanced annual assessment of PRO plus, objective measures of physical activity, diet intake and anthropormorphic factors at four CNICS sites: Case Western Reserve University, University of Alabama at Birmingham, University of Washington, and Fenway Health. This study was registered at #NCT03790501.

Protocol Training Videos (to come soon)

Research Team

Principal Co-Investigators

  • Allison Webel, PhD, RN, FAAN, Frances Payne Bolton School of Nursing, Case Western Reserve University
  • Amanda L. Willig, PhD, RD, University of Alabama at Birmingham


  • Benigno Rodriguez, MD, School of Medicine, Case Western Reserve University
  • Heidi Crane, MD, School of Medicine, University of Washington
  • Michael Saag, MD, School of Medicine, University of Alabama at Birmingham
  • Kenneth Mayer, MD, Fenway Health
  • Dustin Long, PhD, University of Alabama at Birmingham
  • Tom Buford, PhD, University of Alabama at Birmingham


Data collection is ongoing at all four sites. Check back frequently for updated results.

Research Publications

  • Webel, A.R., Willig, A.L., Liu, W., Sattar, A., Boswell, S., Crane, H.M., Hunt, P., Kitahata, M., Matthews, W.C., Saag, M.S., Lederman, M.M., and Rodriguez, B. (2018). Physical Activity Intensity is Associated with Symptom Distress in the CNICS Cohort. AIDS and Behavior. PMID30368620



This project is supported by the National Institutes of Health, National Institute of Nursing Research (R01NR018391).

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