Logo for the PROSPER-HIV study by the Webel Reasearch Lab.

Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of People Living with HIV (PROSPER-HIV)

Years: 2018-2023


People living with HIV (PLHIV) experience a disproportionately high symptom burden (e.g. fatigue, insomnia, pain) with few treatment options. Non-pharmacological treatment options are highly desirable for symptom management among PLHIV who already experience high pill burden from multiple comorbid diseases. Building on our previous work, the PROSPER-HIV study will examine the effect of physical activity and dietary intake as effective symptom management strategies in 850 PLHIV.

Specifically, we will:

  • Identify and characterize longitudinal, objectively-measured, physical activity and dietary patterns among PLHIV;
  • Determine which aspects of physical activity patterns and diet quality are associated with decreased symptom burden and intensity in PLHIV, and if this relationship is moderated by age and sex; and
  • Explore the potential mediating effect of anthropomorphic and physical and physical fitness variables on the relationships between physical activity, dietary patterns, and symptom burden and intensity in PLHIV.

Research Design

We will conduct a four-year, prospective, observational study of 850 Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) participants who will complete an enhanced PRO assessment to measure physical activity and diet, once a year for three years. We will integrate these measures in an enhanced annual assessment of PRO plus, objective measures of physical activity, diet intake and anthropomorphic factors at four CNICS sites: Case Western Reserve University, University of Alabama at Birmingham, University of Washington, and Fenway Health. This study was registered at #NCT03790501.

Protocol Training Videos (to come soon)

    Research Team

    Principal Co-Investigators

    • Allison Webel, PhD, RN, FAAN, Frances Payne Bolton School of Nursing, Case Western Reserve University
    • Amanda L. Willig, PhD, RD, University of Alabama at Birmingham


    • Benigno Rodriguez, MD, School of Medicine, Case Western Reserve University
    • Heidi Crane, MD, School of Medicine, University of Washington
    • Michael Saag, MD, School of Medicine, University of Alabama at Birmingham
    • Kenneth Mayer, MD, Fenway Health
    • Dustin Long, PhD, University of Alabama at Birmingham
    • Tom Buford, PhD, University of Alabama at Birmingham
    Meet the PROSPER Staff
    Head shot of HIV research Robin Rentrope at The Webel Research Lab at the Frances Payne Bolton School of Nursing at Case Western Reserve University in Cleveland, Ohio.

    Robin Rentrope is a Research Assistant on the PROSPER-HIV study. She is a graduate of Case Western Reserve University (CWRU) with a Master in Public Health and Master in Social Work Administration, where she gained academic and practical expertise in evidence-based practices, community and organizational change, and trauma-informed care. Before moving to Cleveland for graduate studies, she served for over three years in the U.S. Peace Corps in Uganda, East Africa, directing HIV programs and developing participatory, community-based interventions targeted at reducing HIV incidence among Uganda's most vulnerable and hard-to-reach populations. Prior to this study, Robin worked as a social worker in Ohio providing support to people living with HIV, and addressing social determinants of health such as environmental, relational, and social barriers to health care needs and HIV-related health outcomes. Robin is passionate about working with the dynamic, resilient, and creative community of people who are living with HIV as well as those devoted to combating stigma, improving care, and finding a cure!

    A fun fact about Robin is that she grew up in New Orleans where she was once a Mardi Gras brass band dancer, a professional cheesemonger, and grassroots urban designer.

    A lifetime of adventure helps her integrate creativity, compassion, joy and humility into the complex work of improving the social, environmental and political landscape affecting the health of our communities.


    Data collection is ongoing at all four sites. Check back frequently for updated results.

    Research Publications

    • Webel, A.R., Willig, A.L., Liu, W., Sattar, A., Boswell, S., Crane, H.M., Hunt, P., Kitahata, M., Matthews, W.C., Saag, M.S., Lederman, M.M., and Rodriguez, B. (2018). Physical Activity Intensity is Associated with Symptom Distress in the CNICS Cohort. AIDS and Behavior. PMID30368620



    This project is supported by the National Institutes of Health, National Institute of Nursing Research (R01NR018391).

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