Apollo Stacy, PhD

Assistant Professor
Department of Molecular Medicine
School of Medicine
Molecular Oncology Program
Case Comprehensive Cancer Center
Center for Microbiome and Human Health
Lerner Research Institute

Research Information

Research Interests

The Apollo Lab deciphers microbiota-host communication in the oral cavity. Using a combination of bacterial genetics, genomics, and animal models, we characterize metabolite-mediated interactions between oral pathogens, commensals, and the host that contribute to gum disease (periodontitis) and oral cancer. Currently, we are engaged in identifying the host-derived metabolites and corresponding metabolic functions in Fusobacterium nucleatum that allow this oncopathogen to outcompete commensals and thereby expand in the oral cancer micro-environment. With this knowledge, we hope to develop microbiota-directed cancer therapies that involve selectively targeting the growth of oncopathogens while not causing collateral damage to the surrounding microbiota.