Small Molecule Drug Development

The Small Molecule Drug Development Shared Resource (SR) optimizes robust assays in 384-well format and to screen large chemical libraries to identify new small molecules for innovative cancer therapeutics.


Case Western Reserve University School of Medicine
Biomedical Research Building 747
2109 Adelbert Rd, Cleveland, OH 44106


Service/Expertise Cost Description
Initial consultation None Investigators receive feedback regarding assay development/HTS goals, while Director and Managing Director suggest optimal assay approaches
Training: Facility Orientation None 1-hr session covering all instruments
Training: Operetta
microscope, or Cytation5

Two 2-hr sessions covering imaging, data storage and analysis

Operetta microscope, or
Cytation5 microscope,
hourly usage

Enables investigators to benefit from automated imaging including live cell systems

Image analysis on a remote

Allows investigators to benefit from high throughput image analysis

Access to automated
dispensers and washers

Provides investigators with access to high data density experimentation

Managing Director support $100/hour General support in assay development and execution
Bioactives Library access (3,200 cpds) $400

Enables pilot screening, pathway elucidation and drugs repurposing

HTS Library access
(100,000 molecules)
$4,000 Enables HTS and drug discovery
All-inclusive screening
Enables dedicated % effort from Managing Director, library access, and equipment time. Can include consumables and reagent costs. Priced on a per-project basis due to varying assay needs.

Available Instruments

Synergy NEO2 plate reader ( Biotek/Agilent)

Synergy NEO2 Plate Reader.

Operetta automated microscope (Perkin Elmer)

Operetta automated microscope

EL406 washer/dispenser (Biotek/Agilent)

EL406 washer/dispenser

MultiFLo dispenser (Biotek/Agilent)

MultiFLo dispenser

Janus MDT liquid handling platform with 50nL 384 pin tool (Perkin Elmer, V&P Scientific)

Janus MDT liquid handling platform

Contact for More Information

Drew Adams, PhD, Director

Yuriy Fedorov, PhD, Managing Director

iLab online scheduler