David L. Wilson, PhD

Professor
Department of Biomedical Engineering
Case School of Engineering
School of Medicine
Professor
Department of Radiology
School of Medicine
Member
Cancer Imaging Program
Case Comprehensive Cancer Center

I use image processing and machine/deep learning on biomedical images to advance health.

Teaching Information

Teaching Interests

biomedical imaging, image processing, machine/deep learning
I am the Robert Herbold Professor of Biomedical Engineering and Radiology, Case Western Reserve University. My research focuses on biomedical image analysis including quantification and visualization of disease in clinical and preclinical models. Tools used include image registration, image segmentation, machine learning, etc. Particularly to serve cancer and stem cell imaging, I developed the cryo-imaging system and software, which enables 3D, color anatomical and fluorescence molecular, microscopic imaging of vast tissues as large as a mouse. This has more recently been extended in the creation of 3D-MUSE systems. Recent clinical imaging work has focused on advanced cardiovascular image analysis of intravascular OCT and CT. I have been PI on numerous federal and state grant awards. I have over 185 peer-reviewed publications and innumerable proceedings papers and abstracts. I serve on editorial boards, NIH study sections, and conference organizing committees. I have had substantial, continuous funding throughout my career. In addition, I have been PI on major development grants, PI on the doctoral student NIH T32 training grant (Interdisciplinary Biomedical Imaging), and advisor to numerous graduate and undergraduate students, all of whom are quite exceptional. I am a founder of BioInVision, Inc., a company that is commercializing cryo-imaging and clinical cardiovascular applications.

Research Information

Research Interests

I am the Robert Herbold Professor of Biomedical Engineering and Radiology, Case Western Reserve University. My research focuses on biomedical image analysis including quantification and visualization of disease in clinical and preclinical models. Tools used include image registration, image segmentation, machine learning, etc. Particularly to serve cancer and stem cell imaging, I developed the cryo-imaging system and software, which enables 3D, color anatomical and fluorescence molecular, microscopic imaging of vast tissues as large as a mouse. This has more recently been extended in the creation of 3D-MUSE systems. Recent clinical imaging work has focused on advanced cardiovascular image analysis of intravascular OCT and CT. I have been PI on numerous federal and state grant awards. I have over 185 peer-reviewed publications and innumerable proceedings papers and abstracts. I serve on editorial boards, NIH study sections, and conference organizing committees. I have had substantial, continuous funding throughout my career. In addition, I have been PI on major development grants, PI on the doctoral student NIH T32 training grant (Interdisciplinary Biomedical Imaging), and advisor to numerous graduate and undergraduate students, all of whom are quite exceptional. I am a founder of BioInVision, Inc., a company that is commercializing cryo-imaging and clinical cardiovascular applications.

View Chris Wirth's Lab

Publications

  • Lack of dystrophin results in abnormal cerebral diffusion and perfusion in vivo; Candida L Goodnough, Ying Gao, Xin Li, Mohammed Q Qutaish, L Henry Goodnough, Joseph Molter, David Wilson, Chris A Flask, Xin Yu - 2014
  • Human mesenchymal stromal cells attenuate graft‐versus‐host disease and maintain graft‐versus‐leukemia activity following experimental allogeneic bone marrow transplantation1; Jeffery J Auletta, Saada K Eid, Patiwet Wuttisarnwattana, Ines Silva, Leland Metheny, Matthew D Keller, Rocio Guardia‐Wolff, Chen Liu, Fangjing Wang, Theodore Bowen, Zhenghong Lee, Luis A Solchaga, Sudipto Ganguly, Megan Tyler, David L Wilson, Kenneth R Cooke - 2014
  • Differences determined by optical coherence tomography volumetric analysis in non‐culprit lesion morphology and inflammation in ST‐segment elevation myocardial infarction and stable angina pectoris patients; Micheli Zanotti Galon, Zhao Wang, Hiram G Bezerra, Pedro Alves Lemos, Audrey Schnell, David L Wilson, Andrew M Rollins, Marco A Costa, Guilherme F Attizzani - 2014

View full list of publications.

Education

Doctor of Philosophy
Electrical Engineering
Rice University
1990
Master of Science
Biomedical Engineering
Penn State University
Bachelor of Science
Physics
West Virginia University

Additional Information

Patents Received

  • 2016, " Analysis of optical tomography (oct) images" US20160213253A1, David Wilson, Hiram Bezerra, & Andrew Rollins.
  • 2014, "Multi-modality, multi-resource, information integration environment" US8856169B2, David Wilson, GQ Zhang, David Wilson, Christopher Flask, & Raymond Muzic.
  • 2014, "Multi-modality, multi-resource, information integration environment" US8856169B2, David Wilson, GQ Zhang, David Wilson, Christopher Flask, & Raymond Muzic.
  • 2012, "Robust GRAPPA MRI Reconstruction" US 8,222,900, David Wilson, & Donglai Huo.
  • 2011, "Constant Variance Filter for Linear Interpolation" US 8,059,907, David Wilson, & Olivier Salvado.
  • 2010, "Imaging system " US7831075B2, David Wilson.
  • 2010, "System and methods for image-guided thermal treatment of tissue" US7699838B2, David Wilson, Gerald Saidel, & Michael Breen.
  • 2003, "A method for delineating an ablation lesion" WO2003099116A1, David Wilson, & Roee Lazebnik.
  • 1994, "Method for locating an edge portion of an aperture in a filter member in X-ray fluoroscopy apparatus" US5282254A, David Wilson.
  • 1991, "Continuously sweeping multiple-pass image acquisition system for peripheral angiography" US4995064A, David Wilson.
  • 1990, "Method for and device for operating x-ray examination device" Method for and device for operating x-ray examination device, David Wilson.
  • 1987, "Angle encoding catheter" US4671291A, David Wilson.