David L. Wilson, PhD

Robert J. Herbold Professor of Biomedical Engineering
Department of Biomedical Engineering
Case School of Engineering, School of Medicine
Department of Radiology
School of Medicine
Cancer Imaging Program
Case Comprehensive Cancer Center

Research Information

Research Interests

  • Image analysis and prediction using machine/deep learning
  • Cardiovascular imaging, particularly CT and intravascular optical coherence tomography imaging
  • Ophthalmological imaging
  • Cellular and molecular imaging
  • Advanced section-and-image microscopy approaches including cryo-imaging and 3D-MUSE suitable for large volumes of interest, including a whole mouse or organ

Much of my research involves minimally invasive, interventional medical imaging. In one project, cancerous tumors are tumors are treated with MR-guided RF thermal ablation. My research group is developing 3D registration, segmentation, and visualization imaging is high definition TV viewing of moving objects in the body. This quantum-limited image sequence is quite noisy, and spatio-temporal processing by the human visual system is an extremely important step in the imaging chain. Thus, we study new digital image enhancement techniques using experimental and theoretical image perception evaluations. In yet another application of imaging to treatment, we use high-resolution, 3D MR images to estimate biomechanical parameters in the fingers and wrist in order to plan tendon transfer surgery and functional neuromuscular stimulation (FNS) interventions. Digital image processing can also be applied to nanoscale images, and we are creating techniques using mathematical morphology to improve AFM images of single biomolecules. 


  • Lack of dystrophin results in abnormal cerebral diffusion and perfusion in vivo; Candida L Goodnough, Ying Gao, Xin Li, Mohammed Q Qutaish, L Henry Goodnough, Joseph Molter, David Wilson, Chris A Flask, Xin Yu - 2014
  • Human mesenchymal stromal cells attenuate graft‐versus‐host disease and maintain graft‐versus‐leukemia activity following experimental allogeneic bone marrow transplantation1; Jeffery J Auletta, Saada K Eid, Patiwet Wuttisarnwattana, Ines Silva, Leland Metheny, Matthew D Keller, Rocio Guardia‐Wolff, Chen Liu, Fangjing Wang, Theodore Bowen, Zhenghong Lee, Luis A Solchaga, Sudipto Ganguly, Megan Tyler, David L Wilson, Kenneth R Cooke - 2014
  • Differences determined by optical coherence tomography volumetric analysis in non‐culprit lesion morphology and inflammation in ST‐segment elevation myocardial infarction and stable angina pectoris patients; Micheli Zanotti Galon, Zhao Wang, Hiram G Bezerra, Pedro Alves Lemos, Audrey Schnell, David L Wilson, Andrew M Rollins, Marco A Costa, Guilherme F Attizzani - 2014

View full list of publications.


Doctor of Philosophy
Electrical Engineering
Rice University
Master of Science
Biomedical Engineering
Penn State University
Bachelor of Science
West Virginia University