My research interests as a genetic epidemiologist focuses on three major areas – deciphering the inherited genetic architecture of complex traits, assessing the shared genetic etiology of complex phenotypes to elucidate the underlying biology, and ascertaining the clinical impact of inherited genetics. My major research interest is cancer, particularly prostate cancer. As an independent researcher I have established myself as an international leader studying the role of germline genetics in cancer susceptibility and progression.
My research has made several impactful discoveries in the field of cancer epidemiology, including the identification of multiple novel genomic regions associated with cancer (i.e. 8q24 in prostate cancer, UCK2 in testicular cancer, etc.) and the impact of germline genetics in risk prediction models of cancer. Furthermore, my involvement creating and organizing large multi-study consortia within and across cancers (i.e. Breast and Prostate Cancer Cohort Consortium, NCI GAME-ON, etc.) has enabled the discovery of cancer genetic risk factors, the generalizability of genetic effects among non-White populations, and evaluated the utility of genetics in cancer risk prediction.