In the realm of hepatobiliary diseases, the role of a transplant hepatologist intertwines the precision of clinical practice with the nuances of scientific exploration. At the Cleveland Clinic, Olumuyiwa Awoniy's vocation as a physician-scientist in this field affords him a unique vantage point—one where he witnesses the interplay of microbial activity and genetic predispositions in shaping the progression of primary sclerosing cholangitis (PSC) and its associated increased risk of hepatobiliary cancers, including gallbladder cancer. Awoniy's clinical foundation, built upon an intricate understanding of PSC and its myriad challenges, informs his research. He delves into the genetic and microbial landscapes that exacerbate PSC, elucidating pathways that may lead from chronic inflammation to malignancy. This journey began with significant findings on how distinct bacterial communities and metabolites influence hepatobiliary inflammation and fibrosis, guiding us toward potential new therapies.
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