I research cell biology of cancer, fundamental mechanisms of membrane trafficking, discovery of signal transduction pathways that regulate the secretory pathway, and their role in cancer.
The Field laboratory studies the cell biology of cancer. We previously discovered cellular machinery involved in vesicle budding from the Golgi for secretory trafficking to the plasma membrane. Many of the components of this machinery have been identified as cancer drivers in human cancers, frequently amplified and overexpressed in a wide variety of human cancers, and appear to represent molecular vulnerabilities for many cancers. The Field laboratory is discovering mechanisms of oncogenic transformation by the Golgi secretory machinery, better understanding of its regulation, and its relationship with other known oncogenic pathways. Furthermore, the lab is developing small molecule inhibitors of the Golgi secretory machinery as an approach to novel cancer therapeutics with mechanism of action orthogonal to all current therapeutic approaches.