Shigemi Matsuyama, DVM, PhD

Associate Professor
Department of Ophthalmology and Visual Sciences
School of Medicine
Associate Professor
Department of Pathology
School of Medicine
Associate Professor
Department of Pharmacology
School of Medicine
Associate Professor
Hematology and Oncology
Department of Medicine
Associate Professor
Division of General Medical Sciences
Associate Professor
Case Western Reserve University
Associate Professor
Case Comprehensive Cancer Center

Primary appointment - Ophthalmology

Other appointments - Pharmacology, Pathology, General Medical Science, Case Comprehensive Cancer Center

Research Information

Research Interests

  • Development of novel small compounds rescuing cells from mitochondria-dependent cell death
  • The mechanism of epigenetic aging
  • The development of the methods controlling aging and age-associated diseases.
  • The mechanism of the inherited retinal dystrophies.
  • Age-dependent corneal endothelial dystrophy.

Awards and Honors

Edmond S. Ricanati, MD Award
Case Western Reserve University
Gund-Harrington Scholar Award
Foundation Fighting Blindness
ASH Scholar Award
American Society of Hematology
Intergen Young Investigator Award
American Association of Cancer Research
Bristol-Myers Squibb Young Investigator Award
American Association of Cancer Research
Veterinary Medical Science Scholar Award
Japanese Society of Veterinary Science
Kato memorial Award for Biological Research
Kato Memorial Foundation

Professional Memberships

Council Member, The Society of Experimental Biology and Medicine
Membership Committee Member, The Society of Expermental Biology and Medicine
Member, Diversity Inclusion Leadership Committee, CWRU
Executive Member, Asian Faculty Association, CWRU



University of Tokyo
Doctor of Veterinary Medicine
University of Tokyo
University of Tokyo
Post Doctoral Training
The Burnham Institute (La Jolla Cancer Research Foundation)

Additional Information


  • Associate Editor (Aging section), Experimental Biology of Medicine
  • Section Editor (Cancer Research), Science Progress
  • Editorial Board member (Cell Biology section), Cells