Research Information
Research Interests
Shi's research is focused on the study of bio-molecular interactions in artificial and live-cell membranes using time-resolved fluorescence methods. The main method used is time-resolved fluorescence spectroscopy known as Pulsed Interleaved Excitation – Fluorescence Cross-Correlation Spectroscopy (PIE-FCCS). He pioneered establishing PIE-FCCS methodology in detecting complex receptor oligomerization and lipid-protein interactions with multiplexed readouts and developed control protein systems for this application. Shi will combine his molecular biophysics expertise with his postdoctoral training in cancer biology and immunology to conduct interdisciplinary studies on the interaction and structure-function relationship of Eph receptors (the largest family of human RTKs) to understand their role in cancers.