Markowitz Colon Cancer Laboratory

Our mission is to identify key genetic causes of colon cancer and to develop better ways for prevention, early detection, and treatment of this disease.

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1.  Baker S, Markowitz S, Fearon E, Willson J, Vogelstein B. (1990) Wild-type p53 suppresses the growth of human colorectal carcinoma cells.  Science 249: 912-915.

2.  Markowitz S, Wang J, Myeroff L, Parsons R, et al. & Willson JKV. (1995) Inactivation of the type II TGF-\xDF receptor in colon cancer cells with microsatellite instability. Science 268:1336-1338.

3.  Veigl M, Kasturi L, Olechnowicz J, Ma A., et al. & Markowitz, S. (1998) Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci (USA) 95:8698-8702.

4.  Grady W, Willis J, Guilford P, Dunbier A, et al. & Markowitz S. (2000) Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genet 26:16-17.

5.  Yan M, Rerko R, Platzer P, Dawson D, et al. & Markowitz, SD. (2004) 15-Hydroxyprostaglandin Dehydrogenase, a COX-2 oncogene antagonist, is a TGF-\xDF induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A 101:17468-17473. {Selected as a \x93From The Cover\x94 Article}.

6.  Chen WD, Han ZJ, Skoletsky J, Olson J, et al. & Markowitz, SD. (2005) Detection in fecal DNA of colon cancer-specifc methylation of the nonexpressed vimentin gene. J Natl Cancer Inst 97:1124-1132.

7.  Myung SJ, Rerko RM, Yan M, Platzer P. et al. & Markowitz SD. (2006) 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.  Proc Natl Acad Sci U S A 103:12098-102.

8. Wood LD, et al., Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. (2007) The Genomic Landscapes of Human Breast and Colorectal Cancers. Science 318:1108-13.

9.  Yan M, Myung SJ, Fink S, Lawrence E, et al. &  Markowitz SD (2009) 15-Hydroxyprostaglandin Dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc Natl Acad Sci U S A 106(23):9409-13.

10. Moinova HR, Leidner RS, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Chen Y, Chak A, Markowitz SD*, Willis JE.  (2012) Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies. Cancer Epidemiol Biomarkers Prev.  21(4):594-600. (Journal Cover Article) (*SM corresponding author).

11. Fink SP, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, Cho E, Giovannucci E, Fuchs CS*, Ogino S*, Markowitz SD*, Chan AT*. (2014) Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (HPGD). (2014) Science translational medicine. 6(233) {*SDM, ATC, SO, CSF equal senior author contributions, first author SPF from Markowitz lab.}

12. Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD*, Willis JE. (2015) Novel recurrently mutated genes in African American colon cancers. Proc Natl Acad Sci U S A. 112(4):1149-54. (SDM corresponding author)

13. Zhang Y, Desai A, Yang SY, Bae KB, et al. & Markowitz SD. (2015) Inhibition of the prostaglandin degrading enzyme 15-PGDH potentiates tissue regeneration. Science 348(6240):aaa2340.                                                                                                                                                                                                         All Publications>>