David Kaelber, MD, PhD, Lead
Jonathan Haines, PhD, Co-Lead
The Cleveland Institute for Computational Biology (CICB) will advance our fundamental knowledge of human biology through the application of computational methods to large and diverse datasets. Further, the CICB will promote the translation of this knowledge into better diagnosis, prognosis, treatment, prevention and delivery of healthcare.
National Clinical Cohort Collaborative (N3C)
The National Clinical Cohort Collaborative (N3C) is a national resource of real‑world clinical data that researchers use to accelerate medical discovery.
Stewarded by the National Center for Advancing Translational Sciences (NCATS), N3C brings together data from more than 90 institutions, harmonizing electronic health record (EHR) data within a secure, centralized data enclave. The enclave supports collaborative research and enables linkage with other data sources to provide a more complete view of patients’ health journeys.
NCATS is expanding the N3C infrastructure to support new disease domains and real‑world data training for researchers.
Protecting patient privacy is central to N3C’s mission. A comprehensive security framework safeguards the enclave and ensures responsible data use.
OnCore Enterprise Research
The OnCore Enterprise Research system is a clinical trial management system that integrates information systems and common operational components with an appropriate balance of centralization vs. decentralization.
Labmatrix
LabmatrixTM is available to all members of the CWRU and affiliated hospitals research community and is housed inside of the CICB SHED (Securely Held Electronic Data) within the CWRU Secure Research Environment (SRE). Access is tightly controlled via role-based security and 2-factor authentication.
Computational Biology Core
The Computational Biology Core is a collaborative and fee for service facility within the CICB aimed at providing computational and analytical support for a variety of research questions. The Core supports standardized and custom pipelines for data processing and analysis of next-generation sequencing data.