Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of People Living with HIV (PROSPER-HIV)
People living with HIV (PLHIV) experience a disproportionately high symptom burden (e.g. fatigue, insomnia, pain) with few treatment options. Non-pharmacological treatment options are highly desirable for symptom management among PLHIV who already experience high pill burden from multiple comorbid diseases. Building on our previous work, the PROSPER-HIV study will examine the effect of physical activity and dietary intake as effective symptom management strategies in 850 PLHIV.
Specifically, we will:
- Identify and characterize longitudinal, objectively-measured, physical activity and dietary patterns among PLHIV;
- Determine which aspects of physical activity patterns and diet quality are associated with decreased symptom burden and intensity in PLHIV, and if this relationship is moderated by age and sex; and
- Explore the potential mediating effect of anthropomorphic and physical fitness variables on the relationships between physical activity, dietary patterns, and symptom burden and intensity in PLHIV.
We will conduct a four-year, prospective, observational study of 850 Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) participants who will complete an enhanced PRO assessment to measure physical activity and diet once a year for three years. We will integrate these measures in an enhanced annual assessment of PRO plus objective measures of physical activity, diet intake and anthropomorphic factors at four CNICS sites: Case Western Reserve University, University of Alabama at Birmingham, University of Washington, and Fenway Health. This study was registered at ClinicalTrials.gov #NCT03790501.
- Allison Webel, PhD, RN, FAAN, Frances Payne Bolton School of Nursing, Case Western Reserve University
- Amanda L. Willig, PhD, RD, University of Alabama at Birmingham
Dr. Christine Horvat Davey is a Research Associate at Case Western Reserve University and a VA Quality Scholar Postdoctoral Fellow at the Cleveland VA. She obtained her PhD in nursing from Case Western Reserve University. She specializes in research involving chronic disease symptom management across comorbidities, especially fatigue and depression. Her dissertation examined gene expression of fatigue in individuals with end stage renal disease. She has collaborated on numerous research studies examining symptoms in people living with HIV with the Webel Research Lab. She currently serves as project director for the PROSPER-HIV study. Christine has funded grants from the American Nurses Foundation, American Nephrology Nurses Association, and Frances Payne Bolton School of Nursing Alumni Association.
Check out our new PROSPER results at the 21st International Workshop on Co-Morbidities and Adverse Drug Reactions in Basel, Switzerland in November, 2019.
Willig A.L., Webel A.R., Westfall A.O., Levitan E.B., Crane H.M., Buford T.W., Burkholder G.A., Willig J.H., Blashill A.J., Moore R.D., Mathews W.C., Zinski A., Muhammad J., Geng E.H., Napravnik S., Eron J.J., Rodriguez B., Bamman M.M., Overton E.T. (2020) Physical activity trends and metabolic health outcomes in people living with HIV in the US, 2008-2015. Progress in CVD, doi: 10.1016/j.pcad.2020.02.005
Webel, A.R., Long, D., Rodriguez, B., Horvat Davey C., Buford, T.W., Crane, H.M., Mayer, K., Saag, M.S., & Willig, A.L. (2020) The PROSPER-HIV Study: A Research Protocol to Examine Relationships Among Physical Activity, Diet Intake, and Symptoms in Adults Living with HIV. Journal of the Association of Nurses in AIDS Care. 31(3), 346-352. doi: 10.1097/JNC.0000000000000145
Webel, A.R., Long, D., Rodriguez, B., Horvat Davey C., Buford, T.W., Crane, H.M., Mayer, K., Saag, M.S., & Willig, A.L. (In press) The PROSPER-HIV Study: A Research Protocol to Examine Relationships Among Physical Activity, Diet Intake, and Symptoms in Adults Living with HIV. Journal of the Association of Nurses in AIDS Care.
- Webel, A.R., Willig, A.L., Liu, W., Sattar, A., Boswell, S., Crane, H.M., Hunt, P., Kitahata, M., Matthews, W.C., Saag, M.S., Lederman, M.M., and Rodriguez, B. (2018). Physical Activity Intensity is Associated with Symptom Distress in the CNICS Cohort. AIDS and Behavior. PMID30368620
- Birmingham Business Journal
This project is supported by the National Institutes of Health, National Institute of Nursing Research (R01NR018391).