The PROSPER-HIV Study

Logo for the PROSPER-HIV study by the Webel Reasearch Lab.

Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of People Living with HIV (PROSPER-HIV)

Years: 2018-2023

Background

People living with HIV (PLHIV) experience a disproportionately high symptom burden (e.g. fatigue, insomnia, pain) with few treatment options. Non-pharmacological treatment options are highly desirable for symptom management among PLHIV who already experience high pill burden from multiple comorbid diseases. Building on our previous work, the PROSPER-HIV study will examine the effect of physical activity and dietary intake as effective symptom management strategies in 850 PLHIV.

Specifically, we will:

  • Identify and characterize longitudinal, objectively-measured, physical activity and dietary patterns among PLHIV;
  • Determine which aspects of physical activity patterns and diet quality are associated with decreased symptom burden and intensity in PLHIV, and if this relationship is moderated by age and sex; and
  • Explore the potential mediating effect of anthropomorphic and physical and physical fitness variables on the relationships between physical activity, dietary patterns, and symptom burden and intensity in PLHIV.

Research Design

We will conduct a four-year, prospective, observational study of 850 Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) participants who will complete an enhanced PRO assessment to measure physical activity and diet, once a year for three years. We will integrate these measures in an enhanced annual assessment of PRO plus, objective measures of physical activity, diet intake and anthropomorphic factors at four CNICS sites: Case Western Reserve University, University of Alabama at Birmingham, University of Washington, and Fenway Health. This study was registered at ClinicalTrials.gov #NCT03790501.

    Research Team

    Principal Co-Investigators

    • Allison Webel, PhD, RN, FAAN, Frances Payne Bolton School of Nursing, Case Western Reserve University
    • Amanda L. Willig, PhD, RD, University of Alabama at Birmingham

    Co-Investigators

    • Benigno Rodriguez, MD, School of Medicine, Case Western Reserve University
    • Heidi Crane, MD, School of Medicine, University of Washington
    • Michael Saag, MD, School of Medicine, University of Alabama at Birmingham
    • Kenneth Mayer, MD, Fenway Health
    • Dustin Long, PhD, University of Alabama at Birmingham
    • Tom Buford, PhD, University of Alabama at Birmingham
    Meet the PROSPER Staff
    Photo of Bridget Noe, researcher on the PROSPER study.

    Bridget Noé is a Research Assistant at Fenway Health for the PROSPER-HIV study. She is a graduate of Boston University with a Bachelor’s and Master’s in Psychology, and first became involved in research as an undergraduate. During her graduate studies, she worked on research with women living with/at risk of HIV. For her dissertation, she investigated how early-life experiences of betrayal relate to current HIV health status, later experiences of abuse, and quality of life.

    Prior to this study, Bridget worked at Massachusetts General Hospital as a Clinical Research Assistant in the Radiation Oncology department’s Sexual Health Clinic. This recently established clinic was founded to research and address the sexual health concerns of patients receiving radiation therapy. While there, she worked specifically with women in treatment for gastrointestinal and gynecological cancers, focusing on the effects of pelvic radiation on women's sexual health and overall quality of life. She is most interested in the intersection between psychology and public health.

    In her spare time, Bridget likes to bake, read dystopian fiction, and watch horror movies.

    Results

    Check out our new PROSPER results at the  21st International Workshop on Co-Morbidities and Adverse Drug Reactions in Basel, Switzerland in November, 2019.

    Research Publications

    • Webel, A.R., Willig, A.L., Liu, W., Sattar, A., Boswell, S., Crane, H.M., Hunt, P., Kitahata, M., Matthews, W.C., Saag, M.S., Lederman, M.M., and Rodriguez, B. (2018). Physical Activity Intensity is Associated with Symptom Distress in the CNICS Cohort. AIDS and Behavior. PMID30368620

    Media

    Support

    This project is supported by the National Institutes of Health, National Institute of Nursing Research (R01NR018391).

    Logos of supporters/partners of the PROSPER-HIV Study