Portfolio of CWRU Startups

Explore Our Portfolio

Get to know some of the many startups to have emerged from Case Western Reserve University.


Afference has made a glove that uses neural simulation to create artificial sensations and touch during digital interactions. Any device can be used to wirelessly connect and make it work. Learn more about Afference.

Amrit/Picture Health

Picture Health used Innoplexus technology to create the Curia app and bring current, accurate and relevant information to cancer patients. Learn more about Amrit/Picture Health.


Anemed aims to create a device that helps people who suffer from sleep apnea; a 3-D printed custom made oral appliance similar to a dental retainer. Learn more about Anemed.


The Atelerix method encapsulates cells in alginate gel, keeping them safe during storage and transport, and then releasing them ready-to-use when they reach their destination. Learn more about Atelerix.

BioChip Labs

BioChip labs analyses blood cells using over ten different laboratory test types, diagnosing disease such as sickle cell disease and thalassemia. Learn more about BioChip Labs.


Biohm makes a variety of probiotics to improve gut health. Their "Total Probiotic" won Microbiome Modulation Product of the Year. Learn more about BIOHM.


Provider of cryo-imaging services intended to offer cellular and molecular imaging functions. The company's cryo-imaging services help in detection of fluorescently tagged stem or cancer cells using multi-spectral fluorescence imaging tools, enabling clients to examine disease or therapeutic processes using various imaging techniques. Learn more about Biolnvision.

Calida Therapeutics

Calida Therapeutics’ ambition is to become a leader in the new field of thrombo-inflammatory disorders. Its mission is to develop monoclonal antibodies to treat and prevent thrombo-inflammatory disorders. Its approach is based on more than 20 years of research conducted in Cleveland, U.S., by researchers from the academic and medical ecosystem. Learn more about Calida Therapeutics.


The CardioInsight™ Workstation takes the ECG signals collected by the CardioInsight™ Mapping Vest and combines them with CT scan data to produce and display simultaneous, bi-atrial and biventricular, 3-D cardiac maps. The workstation and the vest function together as the CardioInsight™ Noninvasive 3D Mapping. CardioInsight was sold to Medtronic in 2015. Learn more about CardioInsight™.


Collamedix is creating a medical device, known as CollaSling, aims to treat stress urinary incontinence in women—urine leakage coinciding with laughing, coughing, sneezing, lifting and exercise—by using proprietary collagen-based materials to provide structural support to human tissue. Learn more about Collamedix.

Convelo Therapeutics

Convelo has developed an innovative and proprietary platform to identify novel drug candidates capable of directly stimulating oligodendrocyte progenitor cells within the CNS to form new myelin. Importantly, Convelo Therapeutics scientists have discovered a central biological pathway that controls myelination in the CNS, including defined drug-targets. These discoveries have allowed Convelo to develop a pipeline of potent drug candidates that are advancing towards clinical testing. Learn more about Convelo Therapeutics.

Edifice Analytics

Edifice Analytics aims to limit energy overconsumption using multiple data point while saving money for businesses. Learn more about Edifice Analytics.

Folio Photonics

Folio Photonics is reenergizing storage media innovation with the first-ever enterprise-scale, immutable active archive solution that delivers breakthrough cost, security, and sustainability benefits. They sell long-lived, high capacity, random access storage mediums impervious to the elements — delivered at the lowest cost per TB. Learn more about Folio Photonics.

Global Health Metrics

Global Health Metrics was founded in 2015 by a team of scientists committed to delivering innovative analytics into medical practice. GHM offers Health Risk Assessments to aid people in analyzing their lifestyle choices and assessing what changes can be made for a longer lifespan and healthier life. Learn more about Global Health Metrics.


Haima uses platelet inspired therapy for treating blood-related ailments. Haima’s lead technology, called SynthoPlate, is a novel, fully-synthetic hemostatic agent that mitigates bleeding by acting at the site of injury and amplifying your body’s natural clotting mechanisms. Learn more about Haima.

Hemex Health

Hemex's Gazelle device tests for hemoglobin disorders within 8 minutes and can be used by anyone. Disorders tested include sickle cell disease (SCD) and beta thalassemia. Early diagnosis could prevent tens of thousands of SCD child deaths each year. Learn more about Hemex Health.


IlumisAR's lead product, the HoloAnatomy® Software Suite transforms the way students learn human anatomy. The HoloAnatomy platform uses advanced mixed-reality technology to illuminate the body in 3D. As a result, students learn faster, retain more vital information, and transcend the classroom with unprecedented collaborative potential. Learn more about IlumisAR.

Intwine Connect

Intwine Connect is a developer of internet technology products designed for monitoring, managing, and optimizing business-critical operations. The company specializes in designing and developing hardware, software, and services including health monitoring, distance learning, and food safety, enabling businesses to improve business processes using Internet of Things (IoT) products and services. Learn more about Intwine Connect.

Molecular Theranostics

Molecular Theranostics is an early stage biotechnology company with a focus on novel imaging technologies. The technologies in the pipelines will address the unmet clinical needs for early detection, risk-stratification, and active surveillance of aggressive cancers and non-invasive assessment of the efficacy of cancer therapies. Learn more about Molecular Theranostics.

Mosaic ImmunoEngineering

Mosaic ImmunoEngineering Inc is a development-stage biotechnology company focused on bridging immunology and engineering to develop novel immunotherapies to treat and prevent cancer and infectious diseases. The company has a single operating segment for the purposes of assessing performance and making operating decisions. Learn more about Mosaic ImmunoEngineering Inc.


Neoindicate's lead products recognize tumors using unique biomarkers, and also act as therapeutics targeted for brain tumors, melanoma, ovarian, breast, lung and prostrate cancers. Learn more about Neoindicate.


NeoProteomics is a structural biology contract research organization, and is one of the only companies using the specific protein footprinting technique to aid with drug discovery and medicinal chemistry. Learn more about NeoProteomics.

NervGen Pharma

NervGen Pharma aims to develop treatments that would help the nervous system repair itself following injury or disease.Their website states that NervGen’s lead drug candidate, NVG-291, is being evaluated in a Phase 1b/2a clinical trial. Learn more about NervGen Pharma.

Neuros Medical‌‌

Neuros Medical developed the product Altius for the treatment of chronic post-amputation phantom limb and residual limb pain. Altius uses Neuros’ patented Bioelectric On-Demand Nerve Block Technology to target pain at the source, the affected peripheral nerves. Learn more about Neuros Medical.


OpsiClear is a developer of an optical imaging technology designed to improve clinical imaging outcomes. The company's imaging technology uses advanced 3D imaging and sample processing techniques, enabling clients to get accurate and efficient clinical histopathology imaging results. Learn more about OpsiClear.

Presidio Medical

Presidion is a developer of neuromodulation platforms designed to establish a class of therapeutic medical devices. The company's platform is created using biotechnology and is developing a bioelectronic medicine for fundamental neuromodulation to establish a new class of therapeutic medical devices, enabling patients to get cures for diseases of neural activities. Learn more about Presidion Medical.


RoadPrintz is a manufacturer of robotic road painting equipment intended to specify and apply paint schemes on roads in minutes. The company's equipment increases road safety by making effective visual street markings more affordable and accessible via robotic street painting, enabling traffic engineers and road painting contractors to reduce the risk of accidents and maintain road safety through enhanced markings. Learn more about RoadPrintz.

Rora Biologics

Rora Biologics is a developer of a T-cell platform designed to provide innovative cell therapies including genetically engineered chimeric antigen receptor T cells to treat cancer patients. The company's platform provides recently discovered stem cell-like memory T cells for making chimeric antigen receptor drugs durable, safer, and long-lasting, along with stand-alone therapy to reconstitute the immune system that is affected by human immunodeficiency viruses infection, enabling healthcare professionals to improve treatment for patients. Learn more about Rora Biologics.

SHC Therapeutics

SHC Therapeutics is a developer of an HIV "vaccine" designed to allow HIV patients latency periods of 12-24 months without treatment, after a few weeks of treatment regimen.

Synapse Biomedical Inc.‌‌

The main product of Synapse Biomedical Inc. is the NeuRx DPS®. Their groundbreaking neurostimulation implant technology is approved by the U.S. Food and Drug Administration (FDA) for treating people with spinal cord injuries (SCI) and ALS patients. With no moving parts, noiseless operation, and its small size, the state-of-the-art NeuRx DPS® is engineered to help you breathe naturally and live more comfortably. Learn more about Synapse Biomedical Inc.


Tevard is a developer of tRNA-based gene therapies designed to address and correct underlying genetic mutations in a precise and regulated manner. The company uses mRNA stabilization and codon suppression to cure rare and severe genetic diseases, helping patients in repairing and restore the expression of genes to their normal levels. Learn more about Tevard.

Trailhead Biosystems

Trailhead Biosystems is a developer of a biotechnology drug and cell therapies designed for the advanced production of various therapeutics. The company merges developmental biology and cell therapeutics with hardware and computerized experimental design and analysis to perform process-specific parameter optimization for customers seeking to develop cell therapies, enabling healthcare clients to reduce the number of experiments and time otherwise needed for running one-factor-at-a-time experiments to optimize a large number of variables. Learn more about Trailhead Biosystems.


XaTek® Inc., a Cleveland-based privately held company, develops technologies to fulfill urgent and emerging healthcare needs. Its ClotChip® device, a portable point-of-care device, provides quantitative and qualitative diagnostic evaluation of a patient’s entire hemostatic process. This device is the realization of XaTek's mission to provide accurate, non-invasive, point-of-care visibility to a patient’s blood clotting risk profile. Learn more about XaTek® Inc.