Explore Our Portfolio
Get to know some of the many startups to have emerged from Case Western Reserve University.
Afference
Afference has made a glove that uses neural simulation to create artificial sensations and touch during digital interactions. Any device can be used to wirelessly connect and make it work. Learn more about Afference.
AlensiaXR (formerly IlumisAR)
Developer of a learning platform intended to transform the way students learn human anatomy. The company's platform uses advanced mixed-reality technology to illuminate the human body in three dimensions which helps students to learn fast, retain vital information and transcend the classroom, enabling students to easily learn anatomical content and universities can reduce the expensive, time-consuming tasks of obtaining and maintaining cadavers. Learn more about AlensiaXR.
Anemed
Anemed aims to create a device that helps people who suffer from sleep apnea; a 3-D printed custom made oral appliance similar to a dental retainer.
ArthroNovus
ArthroNovus is working to create the means to restore and preserve anatomically competent joint replacement parts sourced from your own cells. Learn more about ArthroNovus.
BioChip Labs
BioChip labs analyses blood cells using over ten different laboratory test types, diagnosing disease such as sickle cell disease and thalassemia. Learn more about BioChip Labs.
BIOHM
Biohm makes a variety of probiotics to improve gut health. Their "Total Probiotic" won Microbiome Modulation Product of the Year. Learn more about BIOHM.
Bisc Therapeutics
Bisc Therapeutics is developing first-in-class therapies to preserve vision and prevent blindness in millions of patients with retinal degenerative diseases. Its groundbreaking Bax inhibitor technology protects retinal cells by halting retinal cell death at its core, offering a transformative solution for a range of conditions, including age-related macular degeneration, glaucoma, and inherited retinal disorders. With orally-available treatment, Bisc Therapeutics aims to improve patient outcomes and quality of life without the need for invasive eye injections. Learn more about Bisc Therapeutics.
Calida Therapeutics
Calida Therapeutics’ ambition is to become a leader in the new field of thrombo-inflammatory disorders. Its mission is to develop monoclonal antibodies to treat and prevent thrombo-inflammatory disorders. Its approach is based on more than 20 years of research conducted in Cleveland, U.S., by researchers from the academic and medical ecosystem. Learn more about Calida Therapeutics.
CardioInsight
The CardioInsight™ Workstation takes the ECG signals collected by the CardioInsight™ Mapping Vest and combines them with CT scan data to produce and display simultaneous, bi-atrial and biventricular, 3-D cardiac maps. The workstation and the vest function together as the CardioInsight™ Noninvasive 3D Mapping. CardioInsight was sold to Medtronic in 2015. Learn more about CardioInsight.
Collamedix
Collamedix is creating a medical device, known as CollaSling, aims to treat stress urinary incontinence in women—urine leakage coinciding with laughing, coughing, sneezing, lifting and exercise—by using proprietary collagen-based materials to provide structural support to human tissue. Learn more about Collamedix.
Comorin Therapeutics
Comorin is developing small peptides to treat neurodegenerative disorders.
ContaX Biologics
ContaX is developing wound healing / Factor XII inhibitory peptides for chronic inflammatory conditions.
Convelo Therapeutics
Convelo has developed an innovative and proprietary platform to identify novel drug candidates capable of directly stimulating oligodendrocyte progenitor cells within the CNS to form new myelin. Importantly, Convelo Therapeutics scientists have discovered a central biological pathway that controls myelination in the CNS, including defined drug-targets. These discoveries have allowed Convelo to develop a pipeline of potent drug candidates that are advancing towards clinical testing. Learn more about Convelo Therapeutics.
CrabLine Robotics
Born from the mechanical engineering labs at Case Western Reserve University, CrabLine Robotics is developing specialized, dexterous underwater robotics for industry and military applications. The technologies developed by CrabLine Robotics increase the ability for offshore industries to execute precise work in wet and unsafe environments. Learn more about CrabLine Robotics.
CrewXR
CrewXR is developing a suite of extended reality software platforms that can be used to easily create novel XR content. This will empower organizations to build shared 3D experiences at any scale, making spatial intelligence collaborative, accessible, and transformative. Learn more about CrewXR.
Edifice Analytics
Edifice Analytics aims to limit energy overconsumption using multiple data points while saving money for businesses. Learn more about Edifice Analytics.
Folio Photonics
Folio Photonics is reenergizing storage media innovation with the first-ever enterprise-scale, immutable active archive solution that delivers breakthrough cost, security, and sustainability benefits. They sell long-lived, high capacity, random access storage mediums impervious to the elements — delivered at the lowest cost per TB. Learn more about Folio Photonics.
Galvanix
Provider of sustainable metallization process intended for the rare earth magnet supply chain. The company offers the environmental impact of traditional metallization techniques. Unlike conventional methods that rely on fossil resources and produce harmful greenhouse gases like CO2 and perfluorocarbon, proprietary solution eliminates these emissions, thereby helping environmental and economic efficiency, by creating a greener and sustainable future for rare earth production. Learn more about Galvanix.
Give A Hand Tech
This startup serves as an adoptive home for people with, or who could benefit from, abandoned implantable medical devices. Give A Hand Tech will enable people to gain access to, and keep benefiting from, these devices for the remainder of their lifetimes. Learn more about Give A Hand Tech.
Glengary Brain Health
This Cleveland-based biotechnology company is advancing investigational small-molecule drug P7C3-A20. The company focuses on restoring cellular energy balance by targeting NAD+ levels to potentially reverse neurodegenerative conditions like Alzheimer’s disease and traumatic brain injury.
Global Health Metrics
Global Health Metrics was founded in 2015 by a team of scientists committed to delivering innovative analytics into medical practice. GHM offers Health Risk Assessments to aid people in analyzing their lifestyle choices and assessing what changes can be made for a longer lifespan and healthier life. Learn more about Global Health Metrics.
Haima
Haima uses platelet inspired therapy for treating blood-related ailments. Haima’s lead technology, called SynthoPlate, is a novel, fully-synthetic hemostatic agent that mitigates bleeding by acting at the site of injury and amplifying your body’s natural clotting mechanisms. Learn more about Haima.
Hemex Health
Hemex's Gazelle device tests for hemoglobin disorders within 8 minutes and can be used by anyone. Disorders tested include sickle cell disease (SCD) and beta thalassemia. Early diagnosis could prevent tens of thousands of SCD child deaths each year. Learn more about Hemex Health.
Hydronovo
Hydronovo is changing the therapeutic landscape through Ceviginate (CVGN8), its innovative dry mouth treatment. Ceviginate is the first regenerative treatment designed to restore salivary gland function and reverse the effects of dry mouth. Learn more about Hydronovo.
Intwine Connect
Intwine Connect is a developer of internet technology products designed for monitoring, managing, and optimizing business-critical operations. The company specializes in designing and developing hardware, software, and services including health monitoring, distance learning, and food safety, enabling businesses to improve business processes using Internet of Things (IoT) products and services. Learn more about Intwine Connect.
Invictus Therapeutics
Invictus Therapeutics is at the forefront of insulin technology, creating novel, ultra-rapid, concentrated, room temperature stable insulin analogs to improve the lives of insulin pump users. Their focus on next-generation insulin development combines scientific excellence with a commitment to improving patient outcomes and quality of life. Learn more about Invictus Therapeutics.
Lighthanded Enterprises
Developer of a laser otoscope designed for chronic middle ear effusions. The company's platform gives insight through an additional illumination source, showing up to ninety percent accuracy in detecting OME (otitis media with effusion) while operating, enabling doctors to detect children's middle ear effusions that significantly impair hearing for an extended period. Learn more about Lighthanded Enterprises.
Luminary Therapeutics
Developer of a cell therapy platform designed for cancer and autoimmune diseases. The company's platform creates an engine that completes novel and early therapeutic discovery with the help of a pipeline for B-cell malignancies, autoimmune, solid tumors and autoimmune disorders, enabling doctors to eliminate viral-based cell therapy issues. Learn more about Luminary Therapeutics.
Molecular Theranostics
Molecular Theranostics is an early stage biotechnology company with a focus on novel imaging technologies. The technologies in the pipelines will address the unmet clinical needs for early detection, risk-stratification, and active surveillance of aggressive cancers and non-invasive assessment of the efficacy of cancer therapies. Learn more about Molecular Theranostics.
NeoIndicate
Neoindicate's lead products recognize tumors using unique biomarkers, and also act as therapeutics targeted for brain tumors, melanoma, ovarian, breast, lung and prostrate cancers. Learn more about Neoindicate.
NeoProteomics
NeoProteomics is a structural biology contract research organization, and is one of the only companies using the specific protein footprinting technique to aid with drug discovery and medicinal chemistry. Learn more about NeoProteomics.
NervGen Pharma
NervGen Pharma Corp is a clinical-stage biotech company developing pharmaceutical treatments that enable the nervous system to repair itself following damage, whether due to injury or disease. The company's initial target indication is spinal cord injury, with lead pipeline products NVG-291 and NVG-300. Learn more about NervGen Pharma.
Neuros Medical
Neuros Medical developed the product Altius for the treatment of chronic post-amputation phantom limb and residual limb pain. Altius uses Neuros’ patented Bioelectric On-Demand Nerve Block Technology to target pain at the source, the affected peripheral nerves. Learn more about Neuros Medical.
OpsiClear
OpsiClear is a developer of an optical imaging technology designed to improve clinical imaging outcomes. The company's imaging technology uses advanced 3D imaging and sample processing techniques, enabling clients to get accurate and efficient clinical histopathology imaging results. Learn more about OpsiClear.
Picture Health
Picture Health used Innoplexus technology to create the Curia app and bring current, accurate and relevant information to cancer patients. Learn more about Picture Health.
Polymark Systems
Polymark Systems was founded to bring integrity to things via the application of a software security infrastructure based upon innovative thin-film polymers that are unique, non-clonable, and small. This is a better way to bring secure digital technologies to physical goods by providing better identification, authentication of goods, improved integrity in supply chains, and better data. Learn more about Polymark Systems.
Presidio Medical
Presidion is a developer of neuromodulation platforms designed to establish a class of therapeutic medical devices. The company's platform is created using biotechnology and is developing a bioelectronic medicine for fundamental neuromodulation to establish a new class of therapeutic medical devices, enabling patients to get cures for diseases of neural activities.
Recall Therapeutics
Recall Therapeutics is developing a therapeutic focused on memory restoration for Alzheimer’s disease, with additional applications for schizophrenia and anxiety disorders. Learn more about Recall Therapeutics.
RoadPrintz
RoadPrintz is a manufacturer of robotic road painting equipment intended to specify and apply paint schemes on roads in minutes. The company's equipment increases road safety by making effective visual street markings more affordable and accessible via robotic street painting, enabling traffic engineers and road painting contractors to reduce the risk of accidents and maintain road safety through enhanced markings. Learn more about RoadPrintz.
SHC Therapeutics
SHC Therapeutics is a developer of an HIV "vaccine" designed to allow HIV patients latency periods of 12-24 months without treatment, after a few weeks of treatment regimen. Learn more about SHC Therapeutics.
Symphony Robotics
Symphony Robotics is leading the development and commercialization of an advanced, ultra-maneuverable surgical micro-robot designed to revolutionize neurosurgery, particularly for treating Glioblastoma Multiforme. The core of this technology is a non-linear, flexible micro-robotic arm capable of navigating through complex brain structures with unparalleled precision. This groundbreaking innovation integrates real-time, MRI-guided visualization with cutting-edge AI and computer vision, giving neurosurgeons enhanced control over delicate procedures. Learn more about Symphony Robotics.
Synapse Biomedical Inc.
The main product of Synapse Biomedical Inc. is the NeuRx DPS®. Their groundbreaking neurostimulation implant technology is approved by the U.S. Food and Drug Administration (FDA) for treating people with spinal cord injuries (SCI) and ALS patients. With no moving parts, noiseless operation, and its small size, the state-of-the-art NeuRx DPS® is engineered to help you breathe naturally and live more comfortably. Learn more about Synapse Biomedical Inc.
Tevard
Tevard is a developer of tRNA-based gene therapies designed to address and correct underlying genetic mutations in a precise and regulated manner. The company uses mRNA stabilization and codon suppression to cure rare and severe genetic diseases, helping patients in repairing and restore the expression of genes to their normal levels. Learn more about Tevard.
Trailhead Biosystems
Trailhead Biosystems is a developer of a biotechnology drug and cell therapies designed for the advanced production of various therapeutics. The company merges developmental biology and cell therapeutics with hardware and computerized experimental design and analysis to perform process-specific parameter optimization for customers seeking to develop cell therapies, enabling healthcare clients to reduce the number of experiments and time otherwise needed for running one-factor-at-a-time experiments to optimize a large number of variables. Learn more about Trailhead Biosystems.
Vireo
Vireo is developing therapeutics for the treatment of Graft vs. Host Disease.
Visano Theranostics
Visano Theranostics is transforming the landscape of medical imaging and therapy with innovative nanobubble technology designed to outperform traditional ultrasound contrast agents. Nanobubbles’ smaller scale allows for superior tissue penetration, leading to extended imaging windows and enhanced diagnostic precision. Learn more about Visano Theranostics.
WhichFoodsR Health Technologies
WhichFoodsR Health Technologies is developing an at-home test for personalized monitoring of intestinal inflammation in patients with inflammatory bowel disease.
XaTek
XaTek® Inc., a Cleveland-based privately held company, develops technologies to fulfill urgent and emerging healthcare needs. Its ClotChip® device, a portable point-of-care device, provides quantitative and qualitative diagnostic evaluation of a patient’s entire hemostatic process. This device is the realization of XaTek's mission to provide accurate, non-invasive, point-of-care visibility to a patient’s blood clotting risk profile. Learn more about XaTek® Inc.
Zafer Therapeutics
Zafer Therapeutics is building an MSC-based cell therapy platform that programs naive mesenchymal stromal cells in a precision-designed artificial disease environment so they return to the body as targeted anti-inflammatory therapies. The solution trains natural healing cells to fight autoimmune disease. Learn more about Zafer Therapeutics.