Continuing Research Education Credit (CREC)

The Continuing Research Education Credit (CREC) is a collaborative program between Case Western Reserve University (CWRU), MetroHealth, and University Hospitals, offering free documented training in protecting human subjects. This training complies with NIH education requirements

CREC Program Requirements

Each member of the study team conducting research with human subjects must complete the initial core training through the Collaborative Institutional Training Initiative (CITI) Program before beginning research activities. CITI is a subscription service that offers research-educational content. 

Initial Core Training for CREC Certification   

The initial core training for the CREC certificate is one of the CITI courses below. Select the course that is most relevant to your research or discipline. Only one of the courses will be eligible for credit.

Group 1 Biomedical Research Faculty, Staff & Students Group 2 Social and Behavioral Research Faculty, Staff & Students

Maintaining CREC Certification
Program members must acquire 12 credits every 3 years to maintain their CREC certification. Failure to attain credits will result in removal from the program. Once a member is removed from the program, they must complete the initial core training above.

Transferring CITI Training and Affiliating
Transfer current CITI training by affiliating with the Case Western Reserve University CREC program. Once affiliated, email Additional training may be required based on local criteria and funding sources.
What is current?  Training completed within the last two years.
Are CITI certificates accepted? No. CITI completion reports are required.

CREC and CITI Resources 

Add a Course Credit Application FAQs
Important-to-Remember Register/Add a Course Register or Login CITI
Research @ CWRU Research Ready  Quick Guide

CREC Approved Training 

CREC program members who have completed the initial core training described above can renew their certification using the options listed below.

CITI Courses and Webinars Recorded Seminars and Quizzes

CWRU and UH Research Education               
Together, the offices of Research and Technology Management at CWRU and Research Integration and Education at UH offer a variety of pre-approved seminars and on-demand training in UH GPS throughout the year. For the training that is eligible for CREC, the number of credits will be noted. Review upcoming training at CWRU and ​UH

Office for Human Research Protection (OHRP) Training                     
Balancing Risks and Benefits 2 What is Human Subjects Research (Lesson 2) 5
Equitable Selection of Subjects 2 What are IRBs (Lesson 3) 4
Minimizing Risks in Research 2 IRB Review of Research (Lesson 4) 5
When HHS Regulations Apply (Lesson 1) 2  Institutional Oversight of Human Research (Lesson 5) 4

Please send a copy of the completion certificate to to receive credit.  

Program for Readability in Science and Medicine (PRISM) | 4 credits
PRISM plain language communication training will help research teams improve the readability of consent forms and other participant materials.

Please send a copy of the completion certificate or a screenshot of the "Course Evaluation & Completion (Page 55)" to to receive credit. 

Additional GCP Courses | 6 credits
NIAID Learning Center NIDA Clinical Trials Network Society of Behavioral Medicine

Please send a copy of the completion certificate to to receive credit. 

    CREC Credit Application
    Research education and training activities not included on this page (such as departmental or external seminars and conferences) may also be eligible for CREC. Credits are awarded based on the amount of time and information dedicated to the ethical conduct of human subjects research. You can apply for credit individually or for a group. Applications are accepted with appropriate supporting documentation (program agenda, seminar handouts, list of attendees), before the event or upon its completion.
    Complete the CREC Credit Application,‌ attach the supporting documents above, and email

    National Institutes of Health (NIH) Requirements

    NIH Good Clinical Practice Training Policy
    NIH-funded investigators and staff involved in the conduct, oversight, or management of clinical trials must be trained in Good Clinical Practice (GCP), consistent with the principles of the International Conference on Harmonisation (ICH) E6 every three years. Review the free GCP training offered through CITI or the additional options listed above.
    NIH Training Certification Letter Template
    Investigators who need training documentation for NIH grant submissions should submit a letter to the Office of Sponsored Projects Administration for approval and signature.

    National Science Foundation (NSF) Requirement

    NSF Responsible Conduct of Research FAQs
    All NSF trainees must complete the online Responsible Conduct of Research (RCR) training in CITI once during each career stage. This training is a requirement for each NSF grant proposal where undergraduate, graduate, and postdoctoral researchers receive NSF funds (support from salary and or stipends) to conduct research.
    Choose from one of four CITI RCR courses in biomedical, humanities, physical science, or social and behavioral research. Download the instructions for new CITI users or current CITI users to add the course. This training is not eligible for CREC.


    Yovonda D. Rease  Luke Wieszczyk 
    Research Integrity and Education Manager
    Research Training Manager