We are interested in the following questions:
- How do translational modifications regulate PML function?
- How do the post-translational modifications of PML cross-talk with each other?
- How do PML target genes mediate its cellular function?
Our lab is interested in transcriptional regulation in human health and diseases. Currently, we have two ongoing projects:
Characterizing the biological function of histone deacetylase 7 (HDAC7) and its interacting proteins including alpha actinin 4 (ACTN4)
HDAC7 is a member of class II HDACs. Precise regulation of the subcellular distribution of class II HDACs plays a pivotal role in cell differentiation and animal development. ACTN4 is an HDAC7 interacting protein and mutations in ACTN4 are associated with focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria. We are investigating the function and regulation of HDAC7 and ACTN4 in endothelial cells and podocytes.
Investigating the function and regulation of promyelocytic leukemia protein (PML).
PML is a tumor suppressor protein that control many cellular processes including apoptosis, cell proliferation, senescence, and transcription. PML is subjected to several post-translational modifications such as phosphorylation, sumoylation, acetylation, ubiquitination, and isgylation.