Dr. Mark Cameron applies genomic technologies and bioinformatic methods to identify biomarkers (immune correlates) of infectious diseases, such as HIV, and chronic inflammatory conditions, such as psoriasis. He and his team have broad computational expertise in analyzing across data types and studies, and focus their work on targets or diagnostics that can be used in specific immunotherapy or vaccine design.
Dr. Cameron also directs the genomics activities of several large cores or consortia, including the Case Western Reserve University Applied Functional Genomics Core, the Miami Center for AIDS Research (Inter-CFAR) Bioinformatics Core, the Case Western Reserve University CFAR Systems Biology Core, and the international Early Treated Perinatally Infected individuals: Improving Children’s Lives with an HIV Vaccine (EPIICAL). These collaborative cores allow Dr. Cameron to apply his systems approach and data from gene sequence, to gene transcription, to protein, cellular and antibody function, to find out what goes right or wrong in the immune systems of patients who respond variably to various diseases or treatments.
I investigate the role of interferon signaling genes and the inflammasome in regulating innate and adaptive immune responses in human emerging infectious disease and chronic illness, including COVID-19 research.
Role of interferon signaling genes and the inflammasome in regulating innate and adaptive immune responses.
Find Dr. Cameron's publications here.
- The Journal of infection in Developing Countries, Editor
- Pathogens and Immunity, Associate Editor
Contributions to science:
- Applied novel, low input, multi-omic assays and translation expertise to assess the genome and functional genome of difficult clinical samples from clinical studies and trials
- Identified pro-inflammatory gene correlates of pathogenesis in human subjects versus animal models and mechanisms of their abatement via vaccines or therapies
- Identifying cell subset specific transcriptomic signatures over injury, immune system development and cell survival/differentiation for application to clinical studies
Student and mentee totals, over CWRU career:
- Master’s: 5 mentees
- PhD: 3
- Post-doc: 2
- A sampling of CWRU PhD graduates’ and Postdoctoral fellows’ current careers:
- Nova Southeastern University, Genomics Core
- Harvard T.H. Chan School of Public Health
- Case Western Reserve University