Kaixiang Cao, PhD

Assistant Professor
Department of Biochemistry
School of Medicine
Cancer Genomics and Epigenomics Program
Case Comprehensive Cancer Center
Assistant Professor
Department of Genetics and Genome Sciences
School of Medicine

Research Information

Research Interests

Epigenetic mechanisms play a central role in regulating cell fate determination processes during normal development and pathogenesis. Deciphering these mechanisms will shed light on developing novel therapies for treating human developmental syndromes and cancer. 

Our lab is interested in understanding how epigenetic events, including histone modifications, DNA modifications, and nucleosome positioning, impact cell fate. One major focus of our lab is the roles of lysine methyltransferases (KMTs) and lysine demethylases (KDMs) in regulating stem cell self-renewal and differentiation. We also focus on the crosstalk between different epigenetic pathways in modulating transcription, higher order chromatin architecture, and animal development. Moreover, we are interested in revealing the functions of enhancers and the machineries regulating them in controlling gene expression and cell fate transition. 

We are dedicated to mentoring and training the next generation of exceptional scientists in biomedical research. The ultimate goal of our research is to translate the newfound knowledge to benefit patients and improve public health. 


All of Dr. Cao's publications


Georgia Institute of Technology
Post Doc
Feinberg School of Medicine, Northwestern University