The Mian laboratory has two main areas of interest including studying the genetic and epigenetic mechanisms that promote transdifferentiation toward progressively more lethal tumor subtypes. For example, we have cataloged the unique molecular features of small cell/neuroendocrine carcinoma of the bladder. The lab is using patient samples and model systems to study the fundamental biology and evolution of neuroendocrine carcinoma. Additionally, the Mian lab studies the role of nuclear hormone receptors in regulating DNA repair and resistance to chemotherapy and radiotherapy. We are exploring these systems through the lens of cancer epigenetics to develop new biomarkers and therapies. Our goal is to reverse transdifferentiation and mitigate the emergence of therapeutic resistance in genitourinary and other cancers.