My research and clinical interests in the molecular basis of pediatric cancers began as a pediatric hematology-oncology fellow at Boston Children’s Hospital and in David G. Nathan’s lab with my studies on the newly isolated and produced blood growth factors. Taking a post-doctoral fellowship in Lew Cantley’s lab, I identified the coupling of the Src kinase Lyn with PI 3’kinase in myeloid cells. As a new investigator at the Univ of Pittsburgh, I focused on G-CSF signaling and used gene targeting as an approach to studying cell signaling. Through this experimental model, I was able to establish the specific contributions of Lyn and PI 3’kinase to G-CSF-induced cell cycle progression and survival. The overriding rationale for my studies is to understand basjc biology of inherited bone marrow failure syndromes and myeloid malignancies and translate them into novel therapies. I have also been fortunate to mentor a number of young people who now hold academic appointments at Univ of Rochester, Univ of Michigan, Univ of Virginia, Univ of Tokyo School of Medicine, Univ of Southern California, West Virginia Univ, and Baylor College of Medicine.