Get expert scientific feedback before launch.
The PRMC helps investigators strengthen study design, improve feasibility, and position cancer clinical trials for successful activation and accrual.
Developing a successful clinical trial requires more than a promising research question. Studies must be scientifically rigorous, feasible to conduct, and capable of generating meaningful results.
The Protocol Review & Monitoring Committee (PRMC) provides investigators with scientific review and ongoing study oversight designed to strengthen cancer clinical trials conducted across Case CCC’s consortium. Through this process, investigators receive expert feedback that can improve study design, enhance feasibility, support participant accrual, and increase the likelihood of successful study completion.
All trials that include drugs, devices, and behavioral interventions, as well as prospective observational studies, such as survey studies, are required to be submitted and reviewed by the PRMC. Studies that involve prospective tissue research also require review by the PRMC.
How the PRMC Supports Investigators
The PRMC reviews cancer-related clinical research to help ensure that studies:
- Address important scientific questions
- Are designed to generate meaningful and impactful results
- Are feasible within available resources and patient populations
- Complement existing clinical research efforts across the consortium
- Maintain scientific progress throughout the life of the study
By providing multidisciplinary scientific review, the PRMC helps investigators identify potential challenges early and strengthen protocols before study activation.
Supporting Scientific Progress
The PRMC also monitors ongoing studies to evaluate accrual, scientific progress, and study performance. This process helps identify opportunities to address barriers to enrollment, improve study execution, and ensure research resources are used effectively.
As an NCI-required component of comprehensive cancer centers, the PRMC supports the quality, integrity, and impact of cancer clinical research while helping investigators bring innovative studies to patients.
About Case CCC PRMC
Submission & Review Process
Policies & Guidelines
Protocol & Review Form Templates
- Protocol Templates
- Primary Review
- Statistical Review
- Pharmacy Review
- Clinical Review
- Patient Advocate Review
- Population Science Review
- Behavioral Health Review
- Correlative Science Review
Contact
Email PRMC@case.edu for further information.