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As we begin the year 2020 at the School of Medicine, we are very pleased to congratulate four employees who were honored with Staff Awards for 2018 - 2019. These awards celebrate those who not only have consistently performed their duties in an outstanding manner, but regularly operate with an exemplary attitude and strongly support their colleagues and th

The development of a set of strategies for delivering genome editing complexes directly to stem cells has earned a group of innovators at Case Western Reserve University School of Medicine a first-year grant of nearly $700,000 through the National Institutes of Health (NIH) Somatic Cell Genome Editing Program.

Take a hike! The third annual family- and dog-friendly Hike & Seek for Research will take place Sunday, September 15, at one of the award-winning Cleveland Metroparks, Brecksville Reservation. Guests can hike anytime between 10 a.m. and 2 p.m.  

Investigators at Case Western Reserve University School of Medicine, the Case Comprehensive Cancer Center and University Hospitals Cleveland Medical Center developed the test for early detection of Barrett’s esophagus that offers promise for preventing deaths from esophageal adenocarcinoma.

A new study looking at incidence of disease data nationwide from 2000 to 2016 found a shift in obesity-associated cancers (OACs) to younger individuals. Typically, these cancers are diagnosed at higher rates among people older than 65. The most notable findings pertain to increases in these OACs among non-Hispanic Black and Hispanic women and men for whom certain cancers increased by 200-400%.

There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of the disease in its acute phase and managing it in remission.

Wenquan Zou, MD, PhD, an expert in prion and degenerative neurological diseases, has received a two-year grant for developing diagnostic tools for Alzheimer’s disease, Parkinson’s disease, and other related brain-based degenerative disorders via an innovative skin test that uses ultrasensitive technology. The new test is much less invasive than evaluating brain tissue, which is the only approach for making a definitive diagnosis today.

Acute lymphoblastic leukemia accounts for one in five adult leukemias, and is the most common pediatric cancer in the United States. While new immune therapies have helped improve survival rates, some patients are unresponsive to existing treatment regimens. In addition, drug-related toxicities and drug resistance are rampant for these patients, spurring an urgent need for new therapy options.

Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease.

A new study using a special type of electron microscope using samples cooled to extremely cold temperatures provides critical information for drug developers seeking to reduce nausea and vomiting side effects of cancer treatments.

Riley Tedrow, PhD, a medical entomologist at Case Western Reserve University School of Medicine, has uncovered new findings about malaria transmission in Madagascar. In a recent study published in PLoS Neglected Tropical Diseases, he also describes real-world application of an effective mosquito surveillance strategy using low cost traps and a recently reported tool that simultaneously tests each mosquito for its species, what it fed on, and the presence of malaria parasites.

While federal and professional regulatory systems monitor genetic-editing experiments in university and corporate labs, most research conducted outside of these settings lacks formal oversight.

By combining two well-established antibiotics for the first time, a scientific team led by Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center has delivered a “double whammy” against the pervasive Pseudomonas aeruginosa, a potentially deadly form of bacteria that is a major source of hospital-based infections.

The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes. Using a zebrafish model, researchers at Case Western Reserve University School of Medicine have found that an anti-malarial drug called artemisinin may help prevent hearing loss associated with this genetic disorder.