Our Latest News

A 2.9 Å cryo-EM reconstruction of the 5-HT3A receptor complex with granisetron. A close-up view of the drug-binding pocket and the density map for granisetron.
Sudha Chakrapani, CWRU School of Medicine

New, High-Resolution Images Reveal Clues to Improve Anti-Nausea Drugs for Cancer Patients

July 19, 2019

A new study using a special type of electron microscope using samples cooled to extremely cold temperatures provides critical information for drug developers seeking to reduce nausea and vomiting side effects of cancer treatments.

Mosquito Surveillance Uncovers New Information about Malaria Transmission in Madagascar

July 11, 2019

Riley Tedrow, PhD, a medical entomologist at Case Western Reserve University School of Medicine, has uncovered new findings about malaria transmission in Madagascar. In a recent study published in PLoS Neglected Tropical Diseases, he also describes real-world application of an effective mosquito surveillance strategy using low cost traps and a recently reported tool that simultaneously tests each mosquito for its species, what it fed on, and the presence of malaria parasites.

Keeping Do-It-Yourself Gene Science Safe

July 9, 2019

While federal and professional regulatory systems monitor genetic-editing experiments in university and corporate labs, most research conducted outside of these settings lacks formal oversight.

Combining Antibiotics, Researchers Deliver One-Two Punch against Ubiquitous Bacterium

July 8, 2019

By combining two well-established antibiotics for the first time, a scientific team led by Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center has delivered a “double whammy” against the pervasive Pseudomonas aeruginosa, a potentially deadly form of bacteria that is a major source of hospital-based infections.

Drug to Treat Malaria Could Mitigate Hereditary Hearing Loss

June 11, 2019

The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes. Using a zebrafish model, researchers at Case Western Reserve University School of Medicine have found that an anti-malarial drug called artemisinin may help prevent hearing loss associated with this genetic disorder.

“Giving Kids Hope” Event Benefits Research on Genetic Disorders Affecting Children

June 3, 2019

Case Western Reserve University School of Medicine will host the fourth annual Giving Kids Hope benefit to help fund research in pediatric genetic disorders, on Saturday, June 8, at 6 p.m. The exciting evening will take place at the newly renovated Agora Theatre and Ballroom, and will be emceed by WKYC-TV Senior Health Correspondent Monica Robins, with Cash Explosion host David McCreary as entertainment auctioneer.

Cleveland Researchers Recruiting for Alzheimer’s Disease Clinical Trial

May 28, 2019

Case Western Reserve University School of Medicine and University Hospitals (UH) Cleveland Medical Center have enrolled their first participant in a new clinical research study evaluating the potential benefits of an investigational medicine for people with early onset Alzheimer’s disease.

Key Drug Target Shown Assembling in Real-Time

May 20, 2019

Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout the body—but a recent study shows what happens next. In results published in Cell, researchers outline the timeline of events, including precisely when and how different parts of a GPCR interacts with its G protein signaling partners.

Case Comprehensive Cancer Center Awarded Nearly $9 Million to Expand Access to Clinical Trials

May 16, 2019

Case Comprehensive Cancer Center has been selected, once again, as a Lead Academic Participating Site by the National Cancer Institute. The renewal comes with a six-year, $8.9 million grant that will enable the center to provide patients with additional access to clinical trials through the National Clinical Trials Network. In this renewal, NCI is committed to improving the resources provided for each patient to cover research costs at levels linked to the complexity of the clinical trial.

“The Race” 5K and 1-Mile Run Benefits Breast Cancer Research on Mother’s Day, May 12

April 30, 2019

The 16th annual family-friendly “The Race” will take place this Mother’s Day, Sunday, May 12, at Legacy Village in Lyndhurst. Registration begins at 7:30 a.m. and the 5K starts at 8:30 a.m., followed by the 1-mile run at 9:30 a.m.  

Pig Experiment Raises Ethical Questions Around Brain Damage

April 17, 2019

The brain is more resilient than previously thought. In a groundbreaking experiment published in this week’s issue of Nature, neuroscientists created an artificial circulation system that successfully restored some functions and structures in donated pig brains—up to four hours after the pigs were butchered at a USDA food processing facility.

Case Western Reserve and University Hospitals Researchers Receive Multi-Year Grants to Identify Genetic Biomarkers of Susceptibility and Resistance to Corneal Ulcers

April 3, 2019

More than 125 million people worldwide wear contact lenses, and while many are exposed to relatively common bacteria through their contact lenses, not all contract an eye infection.

Researchers at the Case Western Reserve School of Medicine and University Hospitals (UH) Cleveland Medical Center will study whether a contact-wearer’s genetics may play a role in who does or doesn’t contract infection—especially Microbial keratitis (MK), a bacteria-caused infection of the cornea, which, if left untreated, can cause blindness.    

Patent-Pending Probiotic Could Disrupt Crohn’s Disease Biofilms

April 2, 2019

Probiotics typically aim to rebalance bacteria populations in the gut, but new research suggests they may also help break apart stubborn biofilms. Biofilms are living microbial communities—they provide a haven for microbes and are often resistant to antibiotics. A new study describes a specific probiotic mix that could help patients with gastrointestinal diseases avoid harmful biofilms that can worsen their symptoms.

Medical Students Meet their “Match” when the Clock Strikes Noon

March 15, 2019

Case Western Reserve University School of Medicine Students Become Physicians at Top Hospitals across Cleveland and the Nation Today

Case Western Reserve University School of Medicine Ranked No. 1 in Ohio, and No. 24 nationally, by U.S. News & World Report

March 12, 2019

Case Western Reserve University School of Medicine has been named the No. 1 research-oriented medical school in Ohio, according to the influential annual ranking by U.S. News & World Report. In addition, the school was ranked one of the leading medical schools in America—at number 24.