Program Information
The overarching goal of the Developmental Therapeutics Program (DTP) is to identify and evaluate innovative and novel drugs that will overcome intrinsic cancer cell proliferation and survival mechanisms and to translate these findings into the clinic. The program seeks an enhanced understanding of factors influencing cell replication and signaling that can to be influenced by novel anti-cancer agents. The program leaders foster an environment for facilitated interaction of bench scientists and clinicians involved in anticancer drug development and thus provide a platform for improved patient outcomes. The DTP encourages both bench to bedside as well as bedside to bench research.
Program Themes
- To facilitate discovery and clinical development of novel anti-cancer agents targeting DNA including the following:
- DNA polymerase, ribonucleotide reductase and nucleoside analogues
- DNA repair
- Epigenetics and differentiation
- To augment research and discovery of novel strategies for therapeutic targeting of tumor signal transduction and the microenvironment including the following:
- Signal transduction
- Phosphatase inhibition
- Microenvironment including endothelial and immune factors
Program Activities
Developmental Therapeutics Journal Club
Thursdays at 9am in the 4th floor conference room of the ORIGINAL Taussig Cancer Institute, the ‘R’ building (room R4-013). Breakfast and free parking is provided by a DT Co-Leader.
Program Announcements
NCI CTEP Agents
The NCI has relationships with a variety of biotech and pharmaceutical companies to provide access to new agents for either preclinical or clinical studies. To view the current NCI portfolio, visit the CTEP website and view "CTEP Agents and Active Agreements" located in the "Agents/Drugs" page under the Protocol Development tab.
If you are interested in working with any of the agents on the list, please contact Dr. Afshin Dowlati at afshin.dowlati@case.edu.
Pilot Funds
There are limited funds available for pilot projects for members of the Case Comprehensive Cancer Center for:
- Performing correlative and biomarker studies on physician investigator-initiated studies
- Performing pharmacokinetics on early phase trials
If you are interested in applying for pilot funds from DTP:
- Print the pilot funds applications.
- Submit the application(s) to Marybeth.lipka@uhhospitals.org.
- Applications will be reviewed by the Developmental Therapeutic Program Core Committee and you will be notified of the status of your application within 4-8 weeks.
Program Members
Mohamed Abazeed, MD, PhD
Assistant Professor, Translational Hematology and Oncology Research
abazeem@ccf.org
Jame Abraham, MD
Professor, Hematology and Medical Oncology
abrahaj5@ccf.org
Drew Adams, PhD
Assistant Professor, Genetics & Genome Sciences
dja59@case.edu
David J. Adelstein, MD
Professor, Hematology and Medical Oncology
adelstd@ccf.org
Manmeet S. Ahluwalia, MD
Visiting Assistant Professor, Brain Tumor and Neuro-Oncology Center
ahluwam@ccf.org
James M. Anderson, MD, PhD
Professor, Pathology
james.anderson@case.edu
Lilyana Angelov, MD
Brain Tumor and Neuro-Oncology Center
angelol@ccf.org
Bruce J. Averbook, MD
Professor, Oncology
baverbook@metrohealth.org
Gene H. Barnett, MD
Professor, Brain Tumor and Neuro-Oncology Center
barnetg@ccf.org
Elma D. Baron, MD
Associate Professor, Dermatology
edb4@case.edu
Jerome L. Belinson, MD
Professor, Obstetrics & Gynecology
belinsj@ccf.org
Anthony J. Berdis, PhD
Associate Professor, Chemistry
a.berdis@csuohio.edu
Tithi Biswas, MBBS, MD
Clinical Associate Professor, Radiation Oncology
tithi.biswas@UHhospitals.org
Joseph A. Bokar, MD, PhD
Associate Professor, Medicine-Hematology and Oncology
jab5@case.edu
Joanna M. Brell, MD
Clinical Associate Professor, Hematology and Oncology
jbrell@metrohealth.org
G. Thomas Budd, MD
Professor, Hematology and Medical Oncology
buddg@ccf.org
Clemens Burda, PhD
Professor, Chemistry
cxb77@case.edu
Chee-Wai Cheng, PhD
Professor, Medical Physics
chee-wai.cheng@UHhospitals.org
Chris G. Dealwis, PhD
Associate Professor, Pharmacology
cxd114@case.edu
Afshin Dowlati, MD
Professor, Hematology and Oncology
axd44@case.edu
Jennifer R. Eads, MD
Assistant Professor, Hematology and Oncology
jennifer.eads@UHhospitals.org
Rachel A. Egler, MD, MS
Assistant Professor, Hematology and Oncology
rachel.egler@UHhospitals.org
Paul J. Elson, ScD
Clinical Assistant Professor, Quantitative Health Sciences
elsonp@ccf.org
Pingfu Fu, PhD
Associate Professor, Population and Quantitative Health Sciences
pxf16@case.edu
Stanton L. Gerson, MD
Director, Case Comprehensive Cancer Center
Professor, Medicine-Hematology/Oncology
slg5@case.edu
Meg R. Gerstenblith, MD
Assistant Professor, Dermatology
meg.gerstenblith@UHhospitals.org
Michael K. Gibson, MD, PhD
Associate Professor, Hematology and Oncology
michael.gibson@UHhospitals.org
Brian Grimberg, PhD
Assistant Professor, Pathology, International Health, Infectious Disease & Immunology
brian.grimberg@case.edu
Stephen R. Grobmyer, MD
Professor, Breast Center
grobmys@ccf.org
Jeffrey M. Hardacre, MD
Associate Professor, Surgical Oncology
jeffrey.hardacre@UHhospitals.org
Kord S. Honda, MD
Associate Professor, Dermatology
kord.honda@UHhospitals.org
Deepa Jagadeesh, MD
Assistant Professor, Hematology and Medical Oncology
jagaded@ccf.org
Ritika Jaini, PhD
Assistant Professor, Immunology
jainir@ccf.org
Alok Khorana, MD
Professor, Hematology and Medical Oncology
khorana@ccf.org
Smitha S. Krishnamurthi, MD
Associate Professor, Hematology and Medical Oncology
krishns3@ccf.org
Richard T. Lee, MD
Associate Professor, Hematology and Oncology
richard.t.lee@case.edu
John J. Letterio, MD
Professor, Hematology and Oncology
john.letterio@UHhospitals.org
Liraz Levi, PhD, MSc
Instructor, General Medical Sciences (Oncology)
lxl301@case.edu
Nathan A. Levitan, MD
Professor, Hematology and Oncology
nathan.levitan@UHhospitals.org
Benjamin D. Li, MD
Director, Cancer Center, MetroHealth Medical Center
Professor, Oncology
bli@metrohealth.org
Philip A. Linden, MD
Associate Professor, Surgery
philip.linden@UHhospitals.org
Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology
lindned@ccf.org
Janice A. Lyons, MD
Associate Professor, Radiation Oncology
janice.lyons@UHhospitals.org
Haider Mahdi, MD, MPH
Assistant Professor, Obstetrics and Gynecology
mahdih@ccf.org
Edward V. Maytin, MD, MPH
Assistant Professor, Biomedical Engineering
janice.lyons@UHhospitals.org
Omar Y. Mian, MD, PhD
Assistant Professor, Translational Hematology and Oncology Research
miano@ccf.org
John J. Mieyal, PhD
Professor, Pharmacology
jjm5@case.edu
Monica M. Montano, PhD
Associate Professor, Pharmacology
mxm126@case.edu
Alberto J. Montero, MBA, MD
Associate Professor, Hematology and Medical Oncology
montero2@ccf.org
Goutham Narla, MD, PhD
Associate Professor, General Medicine
gxn71@case.edu
Timothy E. O'Brien, MD
Associate Professor, Hematology and Oncology
tobrien@metrohealth.org
Richard A. Padgett, PhD
Professor, Cellular and Molecular Medicine
padgetr@ccf.org
David M. Peereboom, MD
Professor, Brain Tumor and Neuro-Oncology Center
peerebd@ccf.org
Nathan A. Pennell, MD, PhD
Associate Professor, Hematology and Medical Oncology
penneln@ccf.org
James G. Phillips, PhD
Assistant Professor, Translational Hematology and Oncology Research
phillij5@ccf.org
Irina Pikuleva, PhD
Professor, Pharmacology
irina.pikuleva@case.edu
John J. Pink, PhD
Assistant Professor, General Medical Sciences (Oncology)
john.pink@case.edu
Jon Pokorski, PhD
Assistant Professor, Macromolecular Science and Engineering
jon.pokorski@case.edu
Kimberly E. Resnick, MD
Assistant Professor, Gynecologic Oncology
kresnick@metrohealth.org
Frederic J. Reu, MD
Assistant Professor, Hematologic Oncology and Blood Disorders
reuf@ccf.org
Lisa R. Rogers, DO
Professor, Neurology
lisa.rogers1@UHhospitals.org
Peter G. Rose, MD
Professor, Obstetrics & Gynecology
rosep@ccf.org
Yogen Saunthararajah, MD
Professor, Hematologic Oncology and Blood Disorders
saunthy@ccf.org
Mark D. Schluchter, PhD
Professor, Population and Quantitative Health Sciences
mds11@case.edu
Robert R. Shenk, MD
Associate Professor, Surgical Oncology
robert.shenk@UHhospitals.org
Dale R. Shepard, MD, PhD
Assistant Professor, Hematology and Medical Oncology
shepard@ccf.org
Girish C. Shukla, PhD
Associate Professor, Biological, Geological, and Environmental Sciences
g.shukla@csuohio.edu
Paula Silverman, MD
Associate Professor, Hematology and Oncology
paula.silverman@uhhospitals.org
Andrew E. Sloan, MD
Professor, Neurological Surgery
andrew.sloan@UHhospitals.org
Davendra P.S. Sohal, MD, MPH
Assistant Professor, Hematology and Medical Oncology
sohald@ccf.org
David W. Stepnick, MD, FACS
Associate Professor, Otolaryngology
dstepnick@metrohealth.org
James P. Stevenson, MD
Associate Staff, Hematology and Medical Oncology
stevenj5@ccf.org
Jean T. Stevenson, MD
Associate Professor, Surgery
jstevenson@metrohealth.org
John H. Suh, MD
Professor, Radiation Oncology
suhj@ccf.org
Ahmad Tarhini, MD, PhD
Associate Professor, Medicine
tarhina1@ccf.org
Theodoros N. Teknos, MD
Professor, Otolaryngology
theodoros.teknos@UHhospitals.org
Lois Teston, MD
Assistant Professor, Hematology and Oncology
lois.teston@UHhospitals.org
Gregory P. Tochtrop, PhD
Associate Professor, Chemistry
gpt6@case.edu
Joan E. Trey, MD
Associate Professor, Hematology and Oncology
jet2@case.edu
Vamsidhar Velcheti, MD
Assistant Professor, Hematology and Medical Oncology
velchev@ccf.org
Michael A. Vogelbaum, MD, PhD
Professor, Neurosurgery
vogelbm@ccf.org
Steven E. Waggoner, MD
Associate Professor, Reproductive Biology
steven.waggoner@UHhospitals.org
David N. Wald, MD, PhD
Assistant Professor, Pathology
dnw@case.edu
Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu
Kristine M. Zanotti, MD
Associate Professor, Obstetrics and Gynecology
kristine.zanotti@UHhospitals.org
Maciej Zborowski, PhD
Associate Professor, Biomedical Engineering
zborowm@ccf.org