Program Information
The overarching goal of the Developmental Therapeutics Program (DTP) is to identify and evaluate innovative and novel drugs that will overcome intrinsic cancer cell proliferation and survival mechanisms and to translate these findings into the clinic. The program seeks an enhanced understanding of factors influencing cell replication and signaling that can to be influenced by novel anti-cancer agents. The program leaders foster an environment for facilitated interaction of bench scientists and clinicians involved in anticancer drug development and thus provide a platform for improved patient outcomes. The DTP encourages both bench to bedside as well as bedside to bench research.
Program Themes
- To facilitate discovery and clinical development of novel anti-cancer agents targeting DNA including the following:
- DNA polymerase, ribonucleotide reductase and nucleoside analogues
- DNA repair
- Epigenetics and differentiation
- To augment research and discovery of novel strategies for therapeutic targeting of tumor signal transduction and the microenvironment including the following:
- Signal transduction
- Phosphatase inhibition
- Microenvironment including endothelial and immune factors
Program Activities
Developmental Therapeutics Journal Club
Thursdays at 9am in the 4th floor conference room of the ORIGINAL Taussig Cancer Institute, the ‘R’ building (room R4-013). Breakfast and free parking is provided by a DT Co-Leader.
Program Announcements
NCI CTEP Agents
The NCI has relationships with a variety of biotech and pharmaceutical companies to provide access to new agents for either preclinical or clinical studies. To view the current NCI portfolio, visit the CTEP website and view "CTEP Agents and Active Agreements" located in the "Agents/Drugs" page under the Protocol Development tab.
If you are interested in working with any of the agents on the list, please contact Dr. Afshin Dowlati at afshin.dowlati@case.edu.
Pilot Funds
There are limited funds available for pilot projects for members of the Case Comprehensive Cancer Center for:
- Performing correlative and biomarker studies on physician investigator-initiated studies
- Performing pharmacokinetics on early phase trials
If you are interested in applying for pilot funds from DTP:
- Print the pilot funds applications.
- Submit the application(s) to Marybeth.lipka@uhhospitals.org.
- Applications will be reviewed by the Developmental Therapeutic Program Core Committee and you will be notified of the status of your application within 4-8 weeks.
Program Members
Ata Abbas, PhD
Research ScientistDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: axa335@case.edu
Phone: 216.368.1627
Jame Abraham, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: abrahaj5@ccf.org
Phone: 216.445.0150
Drew Adams, PhD
Assistant ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: drew.adams@case.edu
Phone: 216.368.4922
David J. Adelstein, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: adelstd@ccf.org
Phone: 216.444.9310
Manmeet S. Ahluwalia, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: ahluwam@ccf.org
Phone: 216.636.0007
Mariam AlHilli, MD
Assistant ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: alhillm@ccf.org
James M. Anderson, MD, PhD
ProfessorDepartment of Biomedical EngineeringSchool of EngineeringCase School of EngineeringProfessorDepartment of PathologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: james.anderson@case.edu
Phone: 216.368.0279
Peter Anderson, MD, PhD
ProfessorDepartment of PediatricsSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: andersp@ccf.org
Lilyana Angelov, MD
ProfessorDepartment of Neurological SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: angelol@ccf.org
Bruce J. Averbook, MD
ProfessorDepartment of SurgerySchool of MedicineAssociate ProfessorDepartment of DermatologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: baverbook@metrohealth.org
Phone: 216.778.4391
Gene Barnett, MD, MBA
ProfessorDepartment of Neurological SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: barnetg@ccf.org
Phone: 216.444.5381
Elma Baron, MD
ProfessorDepartment of DermatologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: edb4@case.edu
Phone: 216.368.4971
Anthony J. Berdis, PhD
Assistant ProfessorDepartment of PharmacologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: a.berdis@csuohio.edu
Phone: 216.687.2454
Tithi Biswas, MD
Clinical Associate ProfessorDepartment of Radiation OncologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: tithi.biswas@UHhospitals.org
G. Thomas Budd, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: buddg@ccf.org
Phone: 216.444.6480
Robin Buerki, MD
Assistant ProfessorDepartment of NeurologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: Robin.Buerki@UHhospitals.org
Clemens Burda, PhD
ProfessorDepartment of ChemistryCollege of Arts and SciencesMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: cxb77@case.edu
Phone: 216.368.5918
Sudha Chakrapani, PhD
Joseph T. Wearn ProfessorDepartment of Physiology and BiophysicsSchool of MedicineDirectorCryo-Electron Microscopy CoreDirectorCleveland Center for Membrane & Structural BiologyMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: sxc584@case.edu
Phone: 216.368.3875
Chee-Wai Cheng, PhD, DABR, FAAPM
Adjunct ProfessorDepartment of Radiation OncologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: cxc721@case.edu
Serah Choi, MD, PhD
Assistant ProfessorDepartment of Radiation OncologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: serah.choi@uhhospitals.org
Phone: 216.844.2449
Chris G. Dealwis, PhD
Associate ProfessorDepartment of PharmacologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: cxd114@case.edu
Phone: 216.368.1652
Afshin Dowlati, MD
ProfessorDepartment of MedicineDivision of Hematology and OncologySchool of MedicineAssociate Director for Clinical ResearchCase Comprehensive Cancer CenterMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: axd44@case.edu
Phone: 216.844.1228
Rachel Egler, MD, MS
Associate ProfessorDepartment of PediatricsSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: rachel.egler@UHhospitals.org
Phone: 216.844.7123
Pingfu Fu, PhD
ProfessorDepartment of Population and Quantitative Health SciencesSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: pxf16@case.edu
Phone: 216.368.3911
Stanton L. Gerson, MD
Interim DeanSchool of MedicineInterim Senior Vice President, Medical AffairsSchool of MedicineDirectorCase Comprehensive Cancer CenterSchool of MedicineDirectorNational Center for Regenerative MedicineProfessorDepartment of MedicineSchool of MedicineProfessorDepartment of Environmental Health SciencesEmail: slg5@case.edu
Phone: 216.368.1994
Brian T. Grimberg, PhD
Associate ProfessorDepartment of PathologySchool of MedicineDirector of Cytometry and Imaging ResearchCase Comprehensive Cancer CenterSchool of MedicineMemberCenter for Global Health and DiseasesSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterMemberHIV Co-Infections and Co-morbidities Working GroupCenter for AIDS ResearchEmail: endmalaria@case.edu
Phone: 216.368.6328
Stephen R. Grobmyer, MD
ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: grobmys@ccf.org
Phone: 216.636.2843
Jeffrey M. Hardacre, MD
Associate ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jeffrey.hardacre@UHhospitals.org
Phone: 216.844.7047
Kord S. Honda, MD
ProfessorDepartment of DermatologySchool of MedicineAssistant ProfessorDepartment of PathologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: kord.honda@UHhospitals.org
Phone: 216.368.0236
Deepa Jagadeesh, MD
Clinical Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jagaded@ccf.org
Ritika Jaini, PhD
Assistant ProfessorDepartment of Molecular MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jainir@ccf.org
Phone: 216.444.0613
Babal Jha, PhD
Adjunct Assistant ProfessorDepartment of Molecular MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jhab@ccf.org
Phone: 216.445.9651
Alok Khorana, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: khorana@ccf.org
Phone: 216.636.2690
Smitha S. Krishnamurthi, MD
Associate ProfessorDepartment of MedicineDivision of Hematology and OncologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: krishns3@ccf.org
Pierre Lavertu, MD
ProfessorDepartment of OtolaryngologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: pierre.lavertu@UHhospitals.org
Phone: 216.844.4773
Richard T. Lee, MD
Associate ProfessorDepartment of MedicineDivision of Hematology and OncologySchool of MedicineHelen Moss Foundation-Schoff Family Professor of Integrative OncologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: rtl24@case.edu
Phone: 216.368.5693
John J. Letterio, MD
ProfessorDepartment of PediatricsSchool of MedicineCo-LeaderDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: john.letterio@UHhospitals.org
Phone: 216.844.3345
Liraz Levi , PhD, MS
InstructorDepartment of Molecular MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: lxl301@case.edu
Benjamin D. Li, MD
ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: bli@metrohealth.org
Phone: 216.778.7801
Philip A. Linden, MD
Associate ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: philip.linden@UHhospitals.org
Phone: 216.844.7142
Daniel J. Lindner, MD, PhD
Assistant ProfessorDepartment of Molecular MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: lindned@ccf.org
Phone: 216.445.0548
Janice Lyons, MD
Associate ProfessorDepartment of Radiation OncologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: janice.lyons@UHhospitals.org
Haider Mahdi, MD, MPH
Assistant ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: mahdih@ccf.org
Phone: 216.444.8551
Ankit Mangla, MD
Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: axm1297@case.edu
Edward V. Maytin, MD, PhD
Assistant ProfessorDepartment of Molecular MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: maytine@ccf.org
Phone: 216.445.6676
John J. Mieyal, PhD
Emeritus ProfessorDepartment of PharmacologySchool of MedicineDirectorMolecular Therapeutics Training ProgramSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jjm5@case.edu
Phone: 216.368.3383
Amr Mohamed, MD
Associate ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: amr.mohamed@UHhospitals.org
Monica M. Montano, PhD
ProfessorDepartment of PharmacologySchool of MedicineDirectorHeartLung and Blood Summer Research ProgramSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: mxm126@case.edu
Phone: 216.368.3378
Alberto J. Montero, MD, MBA
Associate ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterCharles J. Nock, MD
Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: charles.nock@va.gov
Phone: 216.791.3800
Lukas Nystrom, MD
Associate ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: nystrol@ccf.org
Phone: 216.445.7164
Timothy E. O'Brien, MD
Associate ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterDavid M. Peereboom, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: peerebd@ccf.org
Phone: 216.445.6068
Nathan A. Pennell, MD, PhD
ProfessorDepartment of MedicineSchool of MedicineDeputy Associate Director for Clinical ResearchCase Comprehensive Cancer CenterMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: penneln@ccf.org
Phone: 216.445.9282
James G. Phillips, PhD
Adjunct Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: phillij5@ccf.org
Phone: 216.442.5514
Irina Pikuleva, PhD
ProfessorDepartment of PharmacologySchool of MedicineProfessorDepartment of Ophthalmology and Visual SciencesSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: irina.pikuleva@case.edu
Phone: 216.368.3823
- David Schwartz Photography
John J. Pink, PhD
Assistant ProfessorCase Comprehensive Cancer CenterDirectorTranslational Research Shared ResourceCase Comprehensive Cancer CenterMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jrp16@case.edu
Phone: 216.368.5420
Kimberly E. Resnick, MD
Assistant ProfessorDepartment of Reproductive BiologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: kresnick@metrohealth.org
Phone: 216.778.1899
Lisa R. Rogers, DO
ProfessorDepartment of NeurologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: lisa.rogers1@UHhospitals.org
Phone: 216.844.3717
Peter G. Rose, MD
ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: rosep@ccf.org
Phone: 216.444.1712
Yogen Saunthararajah, MD
ProfessorDepartment of MedicineSchool of MedicineCo-LeaderDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterMemberHematopoietic and Immune Cancer Biology ProgramCase Comprehensive Cancer CenterMemberCleveland Center for Membrane & Structural BiologySchool of MedicineEmail: saunthy@ccf.org
Phone: 216.444.8170
Mark D. Schluchter , PhD
Professor EmeritusDepartment of Population and Quantitative Health SciencesSchool of MedicineProfessorDepartment of PediatricsSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: mds11@case.edu
Phone: 216.368.2651
Jacob Scott, MD, DPhil
Clinical Assistant ProfessorDepartment of Molecular MedicineSchool of MedicineAdjunct Assistant ProfessorDepartment of PhysicsSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: scottj10@ccf.org
Mohammad Shatat, MD
Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: mas363@case.edu
Robert R. Shenk, MD
Associate ProfessorDepartment of SurgerySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: robert.shenk@UHhospitals.org
Phone: 216.844.3026
Dale R. Shepard, MD, PhD
Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: shepard@ccf.org
Phone: 216.445.5670
Girish C. Shukla , PhD
MemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: g.shukla@csuohio.edu
Phone: 216.523.7422
Paula Silverman, MD
Associate ProfessorDepartment of MedicineDivision of Hematology and OncologySchool of MedicineAssociate ProfessorDepartment of Anesthesiology & Perioperative MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: paula.silverman@UHhospitals.org
Phone: 216.844.5887
Andrew E. Sloan, MD
Professor and Vice Chair of ResearchDepartment of Neurological SurgerySchool of MedicineProfessorDepartment of PathologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterMemberCancer Imaging ProgramCase Comprehensive Cancer CenterEmail: andrew.sloan@UHhospitals.org
Shaun R. Stauffer, PhD
MemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: stauffs2@ccf.org
Phone: 216.444.9974
David W. Stepnick, MD, FACS
Associate ProfessorDepartment of OtolaryngologySchool of MedicineAssociate ProfessorDepartment of Plastic SurgerySchool of MedicineEmail: dstepnick@metrohealth.org
Phone: 216.778.5791
James P. Stevenson, MD
Clinical Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: stevenj5@ccf.org
Phone: 216.636.6888
John H. Suh, MD
ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: suhj@ccf.org
Phone: 216.444.5574
Derek J. Taylor, PhD
Associate ProfessorDepartment of PharmacologySchool of MedicineAssociate ProfessorDepartment of BiochemistrySchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: djt36@case.edu
Phone: 216.368.0684
Theodoros N. Teknos, MD
Clinical ProfessorDepartment of OtolaryngologySchool of MedicineDeputy Director for University HospitalsCase Comprehensive Cancer CenterMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterLois Teston, MD
Assistant ProfessorDepartment of MedicineSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: lois.teston@UHhospitals.org
Phone: 216.896.1868
Gregory P. Tochtrop, PhD
ProfessorDepartment of ChemistryCollege of Arts and SciencesAssistant ProfessorDepartment of PharmacologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: gpt6@case.edu
Phone: 216.368.2351
Joan E. Trey, MD
MemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: jet2@case.edu
Matteo Trucco, MD
MemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: truccom@ccf.org
Phone: 216.444.9085
Roberto Vargas, MD
Clinical Assistant ProfessorDepartment of Obstetrics and GynecologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: vargasr@ccf.org
Steven E. Waggoner, MD
ProfessorDepartment of Reproductive BiologySchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterDavid Wald, MD, PhD
Associate ProfessorDepartment of PathologySchool of MedicineMemberHematopoietic and Immune Cancer Biology ProgramCase Comprehensive Cancer CenterEmail: david.wald@case.edu
Phone: 216.368.5668
Jennifer Yu, MD, PhD
Associate ProfessorDepartment of Molecular MedicineSchool of MedicineCo-LeaderDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: yuj2@ccf.org
Phone: 216.444.0852
Stacey Zahler, DO, MS
Assistant ProfessorDepartment of PediatricsSchool of MedicineMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: zahlers@ccf.org
Maciej Zborowski, PhD
Associate ProfessorDepartment of Molecular MedicineSchool of MedicineAssociate ProfessorDepartment of Biomedical EngineeringCase School of EngineeringMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: zborowm@ccf.org
Phone: 216.445.9330
Mei Zhang, PhD
Assistant ProfessorDepartment of Biomedical EngineeringCase School of EngineeringMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: mxz128@case.edu
Phone: 216.844.3098