Developmental Therapeutics

Program Information

The overall goal of the Developmental Therapeutics (DT) Program is to develop and evaluate novel, rational onco-therapeutics, incorporating companion biomarkers and strategies to minimize therapy-resistance. DT Program members translate toward and into the clinic the most promising laboratory-based research from members across the Case Comprehensive Cancer Center (Case CCC), thus bringing forth new therapeutic agents developed in-house or by outside collaborators. As part of this mission, DT Program members dissect mechanisms of disease response or resistance in novel investigator-initiated clinical trials, across all diseases including particular catchment area problems.   

Program Aims

• Interrogate cancer pathways to develop new and efficacious therapeutics
• Elucidate mechanisms of therapy-resistance and identify biomarkers predictive of response
• Implement early phase clinical trials around novel targets, new agents and combinatorial approaches

Program Activities

Developmental Therapeutics Journal Club
Thursdays at 9am in the 4^th floor conference room of the ORIGINAL Taussig Cancer Institute, the ‘R’ building (room R4-013). Breakfast and free parking is provided by a DT Co-Leader.

Program Announcements

NCI CTEP Agents

The NCI has relationships with a variety of biotech and pharmaceutical companies to provide access to new agents for either preclinical or clinical studies. To view the current NCI portfolio, visit the CTEP website and view "CTEP Agents and Active Agreements" located in the "Agents/Drugs" page under the Protocol Development tab.

If you are interested in working with any of the agents on the list, please contact Dr. Afshin Dowlati at afshin.dowlati@case.edu.

Pilot Funds

There are limited funds available for pilot projects for members of the Case Comprehensive Cancer Center for:

• Performing correlative and biomarker studies on physician investigator-initiated studies
• Performing pharmacokinetics on early phase trials

If you are interested in applying‌ for pilot funds from DTP:

• Print the pilot funds applications‌‌.
• Submit the application(s) to Marybeth.lipka@uhhospitals.org.
• Applications will be reviewed by the Developmental Therapeutic Program Core Committee and you will be notified of the status of your application within 4-8 weeks.

Program Members